This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Bogdanov S, Jurendić T, Sieber R, Gallmann P. Honey for nutrition and health: A review. J Am Coll Nutr 2008;27:677–89. doi: 10.1080/07315724.2008.10719745BogdanovSJurendićTSieberRGallmannPHoney for nutrition and health: A review2008276778910.1080/07315724.2008.1071974519155427Open DOISearch in Google Scholar
Ajila CM, Brar SK, Verma M, Tyagi RD, Godbout S, Valéro JR. Extraction and analysis of polyphenols: Recent trends. Crit Rev Biotechnol 2011;31:227–49. doi: 10.3109/07388551.2010.513677AjilaCMBrarSKVermaMTyagiRDGodboutSValéroJRExtraction and analysis of polyphenols: Recent trends2011312274910.3109/07388551.2010.51367721073258Open DOISearch in Google Scholar
Spano N, Piras I, Ciulu M, Floris I, Panzanelli A, Pilo MI, Piu PC, Sanna G. Reversed-phase liquid chromatographic profile of free amino acids in strawberry-tree (Arbutus unedo L.) honey. J AOAC Int 2009;92:S73–84. doi: 10.1093/jaoac/92.4.S73SpanoNPirasICiuluMFlorisIPanzanelliAPiloMIPiuPCSannaGReversed-phase liquid chromatographic profile of free amino acids in strawberry-tree (Arbutus unedo L.) honey200992S738410.1093/jaoac/92.4.S73Open DOISearch in Google Scholar
Tariba Lovaković B, Lazarus M, Brčić Karačonji I, Jurica K, Živković Semren T, Lušić D, Brajenović N, Pelaić Z, Pizent A. A multi-elemental composition and antioxidant properties of strawberry tree (Arbutus unedo L.) honey from the coastal region of Croatia: Risk-benefit analysis. J Trace Elem Med Biol 2018;45:85–92. doi: 10.1016/j.jtemb.2017.09.022TaribaLovaković BLazarusMBrčićKaračonji IJuricaKŽivkovićSemren TLušićDBrajenovićNPelaićZPizentAA multi-elemental composition and antioxidant properties of strawberry tree (Arbutus unedo L.) honey from the coastal region of Croatia: Risk-benefit analysis201845859210.1016/j.jtemb.2017.09.02229173488Open DOISearch in Google Scholar
Jurič A, Gašić U, Brčić Karačonji, I, Jurica K, Milojković-Opsenica D. The phenolic profile of strawberry tree (Arbutus unedo L.) honey. J Serb Chem Soc 2020;85:1011–9. doi: 10.2298/JSC191217018JJuričAGašićUBrčićKaračonji IJuricaKMilojković-OpsenicaDThe phenolic profile of strawberry tree (Arbutus unedo L.) honey2020851011910.2298/JSC191217018JOpen DOISearch in Google Scholar
Rosa A, Tuberoso CIG, Atzeri A, Melis MP, Bifulco E, Dessì MA. Antioxidant profile of strawberry tree honey and its marker homogentisic acid in several models of oxidative stress. Food Chem 2011;129:1045–53. doi: 10.1016/j.foodchem.2011.05.072RosaATuberosoCIGAtzeriAMelisMPBifulcoEDessìMAAntioxidant profile of strawberry tree honey and its marker homogentisic acid in several models of oxidative stress201112910455310.1016/j.foodchem.2011.05.07225212335Open DOISearch in Google Scholar
Tuberoso CIG, Boban M, Bifulco E, Budimir D, Pirisi FM. Antioxidant capacity and vasodilatory properties of Mediterranean food: The case of Cannonau wine, myrtle berries liqueur and strawberry-tree honey. Food Chem 2013;140:686–91. doi: 10.1016/j.foodchem.2012.09.071TuberosoCIGBobanMBifulcoEBudimirDPirisiFMAntioxidant capacity and vasodilatory properties of Mediterranean food: The case of Cannonau wine, myrtle berries liqueur and strawberry-tree honey20131406869110.1016/j.foodchem.2012.09.07123692754Open DOISearch in Google Scholar
Floris I, Pusceddu M, Satta A. The Sardinian bitter honey: from ancient healing use to recent findings. Antioxidants 2021;10(4):506. doi: 10.3390/antiox10040506FlorisIPuscedduMSattaAThe Sardinian bitter honey: from ancient healing use to recent findings202110450610.3390/antiox10040506806409333805084Open DOISearch in Google Scholar
Jurič A. Phenolic profile and in vitro effects of strawberry tree honey (Arbutus unedo L.) on tumour cells and lymphocytes [PhD thesis]. Zagreb: University of Zagreb, Faculty of Food Technology and Biotechnology; 2021.JuričAZagrebUniversity of Zagreb, Faculty of Food Technology and Biotechnology;2021Search in Google Scholar
Brčić Karačonji I, Jurica K. Development and validation of gas chromatographic-mass spectrometric method for the analysis of homogentisic acid in strawberry tree (Arbutus unedo L.) honey. J AOAC Int 2017;100:889–92. doi: 10.5740/jaoacint.17-0148BrčićKaračonji IJuricaKDevelopment and validation of gas chromatographic-mass spectrometric method for the analysis of homogentisic acid in strawberry tree (Arbutus unedo L.) honey20171008899210.5740/jaoacint.17-014828560954Open DOISearch in Google Scholar
Jurič A, Brčić Karačonji I, Žunec S, Katić A, Gašić U, Milojković Opsenica D, Kopjar N. Protective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro. J Apic Res 2022. doi: 10.1080/00218839.2022.2047421JuričABrčićKaračonji IŽunecSKatićAGašićUMilojkovićOpsenica DKopjarNProtective role of strawberry tree (Arbutus unedo L.) honey against cyto/genotoxic effects induced by ultraviolet B radiation in vitro202210.1080/00218839.2022.2047421Open DOISearch in Google Scholar
Lazarus M, Tariba Lovaković, B, Sekovanić A, Orct T, Jurič A, Prđun S, Denžić Lugomer M, Bubalo D. Combined approach to studying authenticity markers following spatial, temporal and production practice trends in honey from Croatia. Eur Food Res Technol 2021;247:1511–23. doi: 10.1007/s00217-021-03728-8LazarusMTaribaLovaković, BSekovanićAOrctTJuričAPrđunSDenžićLugomer MBubaloDCombined approach to studying authenticity markers following spatial, temporal and production practice trends in honey from Croatia202124715112310.1007/s00217-021-03728-8Open DOISearch in Google Scholar
Osmak M, Eljuga D. The characterization of two human cervical carcinoma HeLa sublines resistant to cisplatin. Res Exp Med 1993;193:389–96. doi: 10.1007/bf02576247OsmakMEljugaDThe characterization of two human cervical carcinoma HeLa sublines resistant to cisplatin19931933899610.1007/bf02576247Open DOISearch in Google Scholar
Batra P, Sharma AK. Anti-cancer potential of flavonoids: recent trends and future perspectives. 3 Biotech 2013;3:439–59. doi: 10.1007/s13205-013-0117-5BatraPSharmaAKAnti-cancer potential of flavonoids: recent trends and future perspectives201334395910.1007/s13205-013-0117-5Open DOISearch in Google Scholar
Mersch-Sundermann V, Knasmüller S, Wu XJ, Darroudi F, Kassie F. Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 2004;198:329–40. doi: 10.1016/j.tox.2004.02.009Mersch-SundermannVKnasmüllerSWuXJDarroudiFKassieFUse of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents20041983294010.1016/j.tox.2004.02.009Open DOISearch in Google Scholar
Sun H, Chow EC, Liu S, Du Y, Pang KS. The Caco-2 cell monolayer: usefulness and limitations. Expert Opin Drug Metab Toxicol 2008;4:395–411. doi: 10.1517/17425255.4.4.395SunHChowECLiuSDuYPangKSThe Caco-2 cell monolayer: usefulness and limitations2008439541110.1517/17425255.4.4.395Open DOISearch in Google Scholar
Chang CF, Chang YC, Lin JT, Yu CW, Kao YT. Evaluation of inhibitors of intestinal UDP-glucuronosyltransferases 1A8 and 1A10 using raloxifene as a substrate in Caco-2 cells: Studies with four flavonoids of Scutellaria baicalensis. Toxicol In Vitro 2021;72:105087. doi: 10.1016/j.tiv.2021.105087ChangCFChangYCLinJTYuCWKaoYTEvaluation of inhibitors of intestinal UDP-glucuronosyltransferases 1A8 and 1A10 using raloxifene as a substrate in Caco-2 cells: Studies with four flavonoids of Scutellaria baicalensis20217210508710.1016/j.tiv.2021.105087Open DOISearch in Google Scholar
Yang SP, Raner GM. Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract. Toxicol Appl Pharmacol 2005;202:140–50. doi: 10.1016/j.taap.2004.06.014YangSPRanerGMCytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract20052021405010.1016/j.taap.2004.06.014Open DOISearch in Google Scholar
Babich H, Borenfreund E. Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay. Appl Environ Microbiol 1991;57:2101–3. doi: 10.1128/aem.57.7.2101-2103.1991BabichHBorenfreundECytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assay1991572101310.1128/aem.57.7.2101-2103.1991Open DOISearch in Google Scholar
Wang H, Joseph JA. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 1999;27:612–6. doi: 10.1016/s0891-5849(99)00107-0WangHJosephJAQuantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader199927612610.1016/s0891-5849(99)00107-0Open DOISearch in Google Scholar
Hempel SL, Buettner GR, O‘Malley YQ, Wessels DA, Flaherty DM. Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2’.7’-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2’.7’-dichlorodihydrofluorescein diacetate and dihydrorhodamine 123. Free Radic Biol Med 1999;27:146–59. doi: 10.1016/s0891-5849(99)00061-1HempelSLBuettnerGRO‘MalleyYQWesselsDAFlahertyDMDihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2’.7’-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2’.7’-dichlorodihydrofluorescein diacetate and dihydrorhodamine 1231999271465910.1016/s0891-5849(99)00061-1Open DOISearch in Google Scholar
Tuberoso CIG, Bifulco E, Caboni P, Cottiglia F, Cabras P, Floris I. Floral markers of strawberry tree (Arbutus unedo L.) honey. J Agric Food Chem 2010;58:384–9. doi: 10.1021/jf9024147TuberosoCIGBifulcoECaboniPCottigliaFCabrasPFlorisIFloral markers of strawberry tree (Arbutus unedo L.) honey201058384910.1021/jf902414719919097Open DOISearch in Google Scholar
Beretta G, Granata P, Ferrero M, Orioli M, Facino RM. Standardization of antioxidant properties of honey by combination of spectrophotometric/fluorometric assays and chemometrics. Anal Chim Acta 2005;533:185–91. doi: 10.1016/j.aca.2004.11.010BerettaGGranataPFerreroMOrioliMFacinoRMStandardization of antioxidant properties of honey by combination of spectrophotometric/fluorometric assays and chemometrics20055331859110.1016/j.aca.2004.11.010Open DOISearch in Google Scholar
Jurič A, Brčić Karačonji I, Kopjar N. Homogentisic acid, a main phenolic constituent of strawberry tree honey, protects human peripheral blood lymphocytes against irinotecan-induced cytogenetic damage in vitro. Chem Biol Interact 2021;349:109672. doi: 10.1016/j.cbi.2021.109672JuričABrčićKaračonji IKopjarNHomogentisic acid, a main phenolic constituent of strawberry tree honey, protects human peripheral blood lymphocytes against irinotecan-induced cytogenetic damage in vitro202134910967210.1016/j.cbi.2021.10967234560068Open DOISearch in Google Scholar
Jaganathan KS, Balaji A, Vellayappan M, Asokan MK, Subramanian AP, John AA, Supriyanto E, Razak SA, Marvibaigi M. A review on antiproliferative and apoptotic activities of natural honey. Anticancer Agents Med Chem 2015;15:48–56. doi: 10.2174/1871520614666140722084747JaganathanKSBalajiAVellayappanMAsokanMKSubramanianAPJohnAASupriyantoERazakSAMarvibaigiMA review on antiproliferative and apoptotic activities of natural honey201515485610.2174/187152061466614072208474725052987Open DOISearch in Google Scholar
Mumtaz PT, Bashir SM, Rather MA, Dar KB, Taban Q. Antiproliferative and apoptotic activities of natural honey. In: Rehman MU, Majid S, editors. Therapeutic applications of honey and its phytochemicals. Singapore: Springer; 2020. p. 345–60.MumtazPTBashirSMRatherMADarKBTabanQAntiproliferative and apoptotic activities of natural honeyRehmanMUMajidSeditorsSingaporeSpringer2020345–6010.1007/978-981-15-6799-5_18Search in Google Scholar
Imtara H, Kmail A, Touzani S, Khader M, Hamarshi H, Saad B, Lyoussi B. Chemical analysis and cytotoxic and cytostatic effects of twelve honey samples collected from different regions in Morocco and Palestine. Evid Based Complement Alternat Med 2019;2019:8768210. doi: 10.1155/2019/8768210ImtaraHKmailATouzaniSKhaderMHamarshiHSaadBLyoussiBChemical analysis and cytotoxic and cytostatic effects of twelve honey samples collected from different regions in Morocco and Palestine20192019876821010.1155/2019/8768210655680231263506Open DOISearch in Google Scholar
Afrin S, Forbes-Hernandez TY, Gasparrini M, Bompadre S, Quiles JL, Sanna G, Spano N, Giampieri F, Battino M. Strawberry-tree honey induces growth inhibition of human colon cancer cells and increases ROS generation: A comparison with manuka honey. Int J Mol Sci 2017;18:613. doi: 10.3390/ijms18030613AfrinSForbes-HernandezTYGasparriniMBompadreSQuilesJLSannaGSpanoNGiampieriFBattinoMStrawberry-tree honey induces growth inhibition of human colon cancer cells and increases ROS generation: A comparison with manuka honey20171861310.3390/ijms18030613537262928287469Open DOISearch in Google Scholar
Afrin S, Giampieri F, Cianciosi D, Pistollato F, Ansary J, Pacetti M, Amici A, Reboredo-Rodríguez P, Simal-Gandara J, Quiles JL, Forbes-Hernández TY, Battino M. Strawberry tree honey as a new potential functional food. Part 1: Strawberry tree honey reduces colon cancer cell proliferation and colony formation ability, inhibits cell cycle and promotes apoptosis by regulating EGFR and MAPKs signaling pathways. J Funct Foods 2019;57:439–52. doi: 10.1016/j.jff.2019.04.035AfrinSGiampieriFCianciosiDPistollatoFAnsaryJPacettiMAmiciAReboredo-RodríguezPSimal-GandaraJQuilesJLForbes-HernándezTYBattinoMStrawberry tree honey as a new potential functional food2019574395210.1016/j.jff.2019.04.035Open DOISearch in Google Scholar
Cheng N, Zhao H, Chen S, He Q, Cao W. Jujube honey induces apoptosis in human hepatocellular carcinoma HepG2 cell via DNA damage, p53 expression, and caspase activation. J Food Biochem 2019;43:e12998. doi: 10.1111/jfbc.12998ChengNZhaoHChenSHeQCaoWJujube honey induces apoptosis in human hepatocellular carcinoma HepG2 cell via DNA damage, p53 expression, and caspase activation201943e1299810.1111/jfbc.1299831373040Open DOISearch in Google Scholar
Acevedo F, Torres P, Oomah BD, de Alencar SM, Prado Massarioli A, Martín-Venegas R, Albarral-Ávila V, Burgos-Díaz C, Ferrer R, Rubilar M. Volatile and non-volatile/semi-volatile compounds and in vitro bioactive properties of Chilean Ulmo (Eucryphia cordifolia Cav.) honey. Food Res Int 2017;94:20–8. doi: 10.1016/j.foodres.2017.01.021AcevedoFTorresPOomahBDdeAlencar SMPradoMassarioli AMartín-VenegasRAlbarral-ÁvilaVBurgos-DíazCFerrerRRubilarMVolatile and non-volatile/semi-volatile compounds and in vitro bioactive properties of Chilean Ulmo (Eucryphia cordifolia Cav.) honey20179420810.1016/j.foodres.2017.01.02128290363Open DOISearch in Google Scholar
Hsu Y-L, Kuo P-L, Lin C-C. Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis. Biochem Pharmacol 2004;67:823–9. doi: 10.1016/j.bcp.2003.09.042HsuY-LKuoP-LLinC-CAcacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis200467823910.1016/j.bcp.2003.09.042Open DOISearch in Google Scholar
Hsu Y-L, Kuo P-L, Liu C-F, Lin C-C. Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells. Cancer Lett 2004;212:53–60. doi: 10.1016/j.canlet.2004.02.019HsuY-LKuoP-LLiuC-FLinC-CAcacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells2004212536010.1016/j.canlet.2004.02.019Open DOISearch in Google Scholar
Pan M-H, Lai C-S, Hsu P-C, Wang Y-J. Acacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species. Agric Food Chem 2005;53:620–30. doi: 10.1021/jf048430mPanM-HLaiC-SHsuP-CWangY-JAcacetin induces apoptosis in human gastric carcinoma cells accompanied by activation of caspase cascades and production of reactive oxygen species2005536203010.1021/jf048430mOpen DOISearch in Google Scholar
Salimi A, Roudkenar MH, Sadeghi L, Mohseni A, Seydi E, Pirahmadi N, Pourahmad J. Selective anticancer activity of acacetin against chronic lymphocytic leukemia using both in vivo and in vitro methods: key role of oxidative stress and cancerous mitochondria. Nutr Cancer 2016;68:1404–16. doi: 10.1080/01635581.2016.1235717SalimiARoudkenarMHSadeghiLMohseniASeydiEPirahmadiNPourahmadJSelective anticancer activity of acacetin against chronic lymphocytic leukemia using both in vivo and in vitro methods: key role of oxidative stress and cancerous mitochondria20166814041610.1080/01635581.2016.1235717Open DOISearch in Google Scholar
Kandhari K, Mishra JPN, Singh RP. Acacetin inhibits cell proliferation, survival, and migration in human breast cancer cells. Int J Pharma Biol Sci 2019;9:443–52. doi: 10.21276/ijpbs.2019.9.1.58KandhariKMishraJPNSinghRPAcacetin inhibits cell proliferation, survival, and migration in human breast cancer cells201994435210.21276/ijpbs.2019.9.1.58Open DOISearch in Google Scholar
You BR, Moon HJ, Han YH, Park WH. Gallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis. Food Chem Toxicol 2010;48:1334–40. doi: 10.1016/j.fct.2010.02.034YouBRMoonHJHanYHParkWHGallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis20104813344010.1016/j.fct.2010.02.034Open DOISearch in Google Scholar
Serrano A, Palacios C, Roy G, Cespón C, Villar ML, Nocito M, González-Porqué P. Derivatives of gallic acid induce apoptosis in tumoral cell lines and inhibit lymphocyte proliferation. Arch Biochem Biophys 1998;350:49–54. doi: 10.1006/abbi.1997.0474SerranoAPalaciosCRoyGCespónCVillarMLNocitoMGonzález-PorquéPDerivatives of gallic acid induce apoptosis in tumoral cell lines and inhibit lymphocyte proliferation1998350495410.1006/abbi.1997.0474Open DOISearch in Google Scholar
Wang T, Gong X, Jiang R, Li H, Du W, Kuang G. Ferulic acid inhibits proliferation and promotes apoptosis via blockage of PI3K/Akt pathway in osteosarcoma cell. Am J Transl Res 2016;8:968–80. PMCID: PMC4846940WangTGongXJiangRLiHDuWKuangGFerulic acid inhibits proliferation and promotes apoptosis via blockage of PI3K/Akt pathway in osteosarcoma cell2016896880PMCID: PMC4846940Search in Google Scholar
Chang W-C, Hsieh C-H, Hsiao M-W, Lin W-C, Hung Y-C, Ye J-C. Caffeic acid induces apoptosis in human cervical cancer cells through the mitochondrial pathway. Taiwan Obstet Gynecol 2010;49:419–24. doi: 10.1016/S1028-4559(10)60092-7ChangW-CHsiehC-HHsiaoM-WLinW-CHungY-CYeJ-CCaffeic acid induces apoptosis in human cervical cancer cells through the mitochondrial pathway2010494192410.1016/S1028-4559(10)60092-7Open DOISearch in Google Scholar
Kabała-Dzik A, Rzepecka-Stojko A, Kubina R, Jastrzębska-Stojko Ż, Stojko R, Wojtyczka RD, Stojko J. Comparison of two components of propolis: caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) to induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-231. Molecules 2017;22(9):1554. doi: 10.3390/molecules22091554Kabała-DzikARzepecka-StojkoAKubinaRJastrzębska-StojkoŻStojkoRWojtyczkaRDStojkoJComparison of two components of propolis: caffeic acid (CA) and caffeic acid phenethyl ester (CAPE) to induce apoptosis and cell cycle arrest of breast cancer cells MDA-MB-2312017229155410.3390/molecules22091554615142628926932Open DOISearch in Google Scholar
Yin M-C, Lin C-C, Wu H-C, Tsao S-M, Hsu C-K. Apoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action. J Agric Food Chem 2009;57:6468–73. doi: 10.1021/jf9004466YinM-CLinC-CWuH-CTsaoS-MHsuC-KApoptotic effects of protocatechuic acid in human breast, lung, liver, cervix, and prostate cancer cells: potential mechanisms of action20095764687310.1021/jf900446619601677Open DOISearch in Google Scholar
Spilioti E, Jaakkola M, Tolonen T, Lipponen M, Virtanen V, Chinou I, Kassi E, Karabournioti S, Moutsatsou P. Phenolic acid composition, antiatherogenic and anticancer potential of honeys derived from various regions in Greece. PLoS One 2014;9(4):e94860. doi: 10.1371/journal.pone.0094860SpiliotiEJaakkolaMTolonenTLipponenMVirtanenVChinouIKassiEKarabourniotiSMoutsatsouPPhenolic acid composition, antiatherogenic and anticancer potential of honeys derived from various regions in Greece201494e9486010.1371/journal.pone.0094860399405724752205Open DOISearch in Google Scholar
Choi J-A, Kim J-Y, Lee J-Y, Kang C-M, Kwon H-J, Yoo Y-D, Kim T-W, Lee Y-S, Lee S-J. Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int J Oncol 2001;19:837–44. doi: 10.3892/ijo.19.4.837ChoiJ-AKimJ-YLeeJ-YKangC-MKwonH-JYooY-DKimT-WLeeY-SLeeS-JInduction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin2001198374410.3892/ijo.19.4.83711562764Open DOISearch in Google Scholar
Hashemzaei M, Delarami Far A, Yari A, Heravi RE, Tabrizian K, Taghdisi SM, Sadegh SE, Tsarouhas K, Kouretas D, Tzanakakis G, Nikitovic D, Anisimov NY, Spandidos DA, Tsatsakis AM, Rezaee R. Anticancer and apoptosis inducing effects of quercetin in vitro and in vivo. Oncol Rep 2017;38:819–28. doi: 10.3892/or.2017.5766HashemzaeiMDelaramiFar AYariAHeraviRETabrizianKTaghdisiSMSadeghSETsarouhasKKouretasDTzanakakisGNikitovicDAnisimovNYSpandidosDATsatsakisAMRezaeeRAnticancer and apoptosis inducing effects of quercetin in vitro and in vivo2017388192810.3892/or.2017.5766556193328677813Open DOISearch in Google Scholar
Kumar MAS, Nair M, Hema PS, Mohan J, Santhoshkumar TR. Pinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells. Mol Carcinog 2007;46:231–41. doi: 10.1002/mc.20272KumarMASNairMHemaPSMohanJSanthoshkumarTRPinocembrin triggers Bax-dependent mitochondrial apoptosis in colon cancer cells2007462314110.1002/mc.2027217186548Open DOISearch in Google Scholar
Zheng Y, Wang K, Wu Y, Chen Y, Chen X, Hu CW, Hu F. Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells. Cancer Lett 2018;431:31–42. doi: 10.1016/j.canlet.2018.05.026ZhengYWangKWuYChenYChenXHuCWHuFPinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells2018431314210.1016/j.canlet.2018.05.02629807112Open DOISearch in Google Scholar
Budhraja A, Gao N, Zhang Z, Son YO, Cheng S, Wang X, Ding S, Hitron A, Chen G, Luo J, Shi X. Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. Mol Cancer Ther 2012;11:132–42. doi: 10.1158/1535-7163.MCT-11-0343BudhrajaAGaoNZhangZSonYOChengSWangXDingSHitronAChenGLuoJShiXApigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo2012111324210.1158/1535-7163.MCT-11-0343443072722084167Open DOISearch in Google Scholar
Yang J, Pi C, Wang G. Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells. Biomed Pharmacother 2018;103:699–707. doi: 10.1016/j.biopha.2018.04.072YangJPiCWangGInhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells201810369970710.1016/j.biopha.2018.04.07229680738Open DOISearch in Google Scholar
Woo KJ, Jeong Y-J, Park J-W, Kwon TK. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochem Biophys Res Commun 2004;325:1215–22. doi: 10.1016/j.bbrc.2004.09.225WooKJJeongY-JParkJ-WKwonTKChrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells200432512152210.1016/j.bbrc.2004.09.22515555556Open DOISearch in Google Scholar
Khoo BY, Chua SL, Balaram P. Apoptotic effects of chrysin in human cancer cell lines. Int J Mol Sci 2010;11:2188–99. doi: 10.3390/ijms11052188KhooBYChuaSLBalaramPApoptotic effects of chrysin in human cancer cell lines20101121889910.3390/ijms11052188288510120559509Open DOISearch in Google Scholar
Samarghandian S, Azimi-Nezhad M, Borji A, Hasanzadeh M, Jabbari F, Farkhondeh T, Samini M. Inhibitory and cytotoxic activities of chrysin on human breast adenocarcinoma cells by induction of apoptosis. Pharmacogn Mag 2016;12(Suppl 4):S436–40. doi: 10.4103/0973-1296.191453SamarghandianSAzimi-NezhadMBorjiAHasanzadehMJabbariFFarkhondehTSaminiMInhibitory and cytotoxic activities of chrysin on human breast adenocarcinoma cells by induction of apoptosis201612Suppl 4S4364010.4103/0973-1296.191453506812027761071Open DOISearch in Google Scholar
Ruiz de Almodóvar JM, Núñez MI, McMillan TJ, Olea N, Mort C, Villalobos M, Pedraza V, Steel GG. Initial radiation-induced DNA damage in human tumour cell lines: a correlation with intrinsic cellular radiosensitivity. Br J Cancer 1994;69:457–62. doi: 10.1038/bjc.1994.83Ruizde Almodóvar JMNúñezMIMcMillanTJOleaNMortCVillalobosMPedrazaVSteelGGInitial radiation-induced DNA damage in human tumour cell lines: a correlation with intrinsic cellular radiosensitivity1994694576210.1038/bjc.1994.8319688658123473Open DOISearch in Google Scholar
Dunne AL, Price ME, Mothersill C, McKeown SR, Robson T, Hirst DG. Relationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells. Br J Cancer 2003;89:2277–83. doi: 10.1038/sj.bjc.6601427DunneALPriceMEMothersillCMcKeownSRRobsonTHirstDGRelationship between clonogenic radiosensitivity, radiation-induced apoptosis and DNA damage/repair in human colon cancer cells20038922778310.1038/sj.bjc.6601427239528614676806Open DOISearch in Google Scholar
Jariwalla RJ, Gangapurkar B, Nakamura D. Differential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium. Br J Nutr 2008;101:182–9. doi: 10.1017/S0007114508998305JariwallaRJGangapurkarBNakamuraDDifferential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium2008101182910.1017/S000711450899830518549510Open DOISearch in Google Scholar
Szumiel I. Intrinsic radiation sensitivity: cellular signaling is the key. Radiat Res 2008;169:249–58. doi: 10.1667/RR1239.1SzumielIIntrinsic radiation sensitivity: cellular signaling is the key20081692495810.1667/RR1239.118302493Open DOISearch in Google Scholar
Kustiawan PM, Puthong S, Arung ET, Chanchao C. In vitro cytotoxicity of Indonesian stingless bee products against human cancer cell lines. Asian Pac J Trop Biomed 2014;4:549–56. doi: 10.12980/APJTB.4.2014APJTB-2013-0039KustiawanPMPuthongSArungETChanchaoCIn vitro cytotoxicity of Indonesian stingless bee products against human cancer cell lines201445495610.12980/APJTB.4.2014APJTB-2013-0039403282925183275Open DOISearch in Google Scholar
Lawal AO, Ellis E. Differential sensitivity and responsiveness of three human cell lines HepG2, 1321N1 and HEK 293 to cadmium. J Toxicol Sci 2010;35:465–78. doi: 10.2131/jts.35.465LawalAOEllisEDifferential sensitivity and responsiveness of three human cell lines HepG2, 1321N1 and HEK 293 to cadmium2010354657810.2131/jts.35.46520686333Open DOISearch in Google Scholar
Martin-Cordero C, Leon-Gonzalez AJ, Calderon-Montano JM, Burgos-Moron E, Lopez-Lazaro M. Pro-oxidant natural products as anticancer agents. Curr Drug Targets 2012;13:1006–28. doi: 10.2174/138945012802009044Martin-CorderoCLeon-GonzalezAJCalderon-MontanoJMBurgos-MoronELopez-LazaroMPro-oxidant natural products as anticancer agents20121310062810.2174/13894501280200904422594470Open DOISearch in Google Scholar
Carocho M, Ferreira ICFR. A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food Chem Toxicol 2013;51:15–25. doi: 10.1016/j.fct.2012.09.021CarochoMFerreiraICFRA review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives201351152510.1016/j.fct.2012.09.02123017782Open DOISearch in Google Scholar
Khan ZS, Chatterjee NS, Shabeer TPA, Shaikh S, Banerjee K. Profile of triacylglycerols, phenols, and vitamin E of Manjari Medika grape seed oil and cake: Introducing a novel Indian variety. Eur J Lipid Sci Technol 2020;122(4):1900356. doi: 10.1002/ejlt.201900356KhanZSChatterjeeNSShabeerTPAShaikhSBanerjeeKProfile of triacylglycerols, phenols, and vitamin E of Manjari Medika grape seed oil and cake: Introducing a novel Indian variety20201224190035610.1002/ejlt.201900356Open DOISearch in Google Scholar
Eghbaliferiz S, Iranshahi M. Prooxidant activity of polyphenols, flavonoids, anthocyanins and carotenoids: Updated review of mechanisms and catalyzing metals. Phytother Res 2016;30:1379–91. doi: 10.1002/ptr.5643EghbaliferizSIranshahiMProoxidant activity of polyphenols, flavonoids, anthocyanins and carotenoids: Updated review of mechanisms and catalyzing metals20163013799110.1002/ptr.564327241122Open DOISearch in Google Scholar
Kang KA, Chae S, Lee KH, Zhang R, Jung MS, You HJ, Kim JS, Hyun JW. Antioxidant effect of homogentisic acid on hydrogen peroxide induced oxidative stress in human lung fibroblast cells. Biotechnol Bioprocess Eng 2005;10:556–63. doi: 10.1007/BF02932294KangKAChaeSLeeKHZhangRJungMSYouHJKimJSHyunJWAntioxidant effect of homogentisic acid on hydrogen peroxide induced oxidative stress in human lung fibroblast cells2005105566310.1007/BF02932294Open DOISearch in Google Scholar
Martin JP Jr, Batkoff B. Homogentisic acid autoxidation and oxygen radical generation: implications for the etiology of alkaptonuric arthritis. Free Radic Biol Med 1987;3:241–50. doi: 10.1016/s0891-5849(87)80031-xMartinJPJrBatkoffBHomogentisic acid autoxidation and oxygen radical generation: implications for the etiology of alkaptonuric arthritis198732415010.1016/s0891-5849(87)80031-xOpen DOISearch in Google Scholar
Hiraku Y, Yamasaki M, Kawanishi S. Oxidative DNA damage induced by homogentisic acid, a tyrosine metabolite. FEBS Lett 1998;432:13– 6. doi: 10.1016/s0014-5793(98)00823-0HirakuYYamasakiMKawanishiSOxidative DNA damage induced by homogentisic acid, a tyrosine metabolite199843213–610.1016/s0014-5793(98)00823-0Open DOISearch in Google Scholar
Lodovici M, Guglielmi F, Meoni M, Dolara P. Effect of natural phenolic acids on DNA oxidation in vitro. Food Chem Toxicol 2001;39:1205–10. doi: 10.1016/s0278-6915(01)00067-9LodoviciMGuglielmiFMeoniMDolaraPEffect of natural phenolic acids on DNA oxidation in vitro20013912051010.1016/s0278-6915(01)00067-9Open DOISearch in Google Scholar
Yen G-C, Duh P-D, Tsai H-L, Huang S-L. Pro-oxidative properties of flavonoids in human lymphocytes. Biosci Biotechnol Biochem 2003;67:1215–22. doi: 10.1271/bbb.67.1215YenG-CDuhP-DTsaiH-LHuangS-LPro-oxidative properties of flavonoids in human lymphocytes20036712152210.1271/bbb.67.1215Open DOISearch in Google Scholar
Sohi KK, Mittal N, Hundal MK, Khanduja KL. Gallic acid, an antioxidant, exhibits antiapoptotic potential in normal human lymphocytes: A Bcl-2 independent mechanism. J Nutr Sci Vitaminol (Tokyo) 2003;49:221–7. doi: 10.3177/jnsv.49.221SohiKKMittalNHundalMKKhandujaKLGallic acid, an antioxidant, exhibits antiapoptotic potential in normal human lymphocytes: A Bcl-2 independent mechanism200349221710.3177/jnsv.49.221Open DOISearch in Google Scholar
Bhat SH, Azmi AS, Hadi SM. Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties. Toxicol Appl Pharmacol 2007;218:249–55. doi: 10.1016/j.taap.2006.11.022BhatSHAzmiASHadiSMProoxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: involvement of endogenous copper and a putative mechanism for anticancer properties20072182495510.1016/j.taap.2006.11.022Open DOISearch in Google Scholar
Maistro EL, Angeli JPF, Andrade SF, Mantovani MS. In vitro genotoxicity assessment of caffeic, cinnamic and ferulic acids. Genet Mol Res 2011;10:1130–40. doi: 10.4238/vol10-2gmr1278MaistroELAngeliJPFAndradeSFMantovaniMSIn vitro genotoxicity assessment of caffeic, cinnamic and ferulic acids20111011304010.4238/vol10-2gmr1278Open DOISearch in Google Scholar
Chedea VS, Choueiri L, Jisaka M, Kefalas P. o-Quinone involvement in the prooxidant tendency of a mixture of quercetin and caffeic acid. Food Chem 2012;135:1999–2004. doi: 10.1016/j.foodchem.2012.06.094ChedeaVSChoueiriLJisakaMKefalasPo-Quinone involvement in the prooxidant tendency of a mixture of quercetin and caffeic acid20121351999200410.1016/j.foodchem.2012.06.094Open DOISearch in Google Scholar
Metodiewa D, Jaiswal AK, Cenas N, Dickancaité E, Segura-Aguilar J. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic Biol Med 1999;26:107–16. doi: 10.1016/s0891-5849(98)00167-1MetodiewaDJaiswalAKCenasNDickancaitéESegura-AguilarJQuercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product1999261071610.1016/s0891-5849(98)00167-1Open DOISearch in Google Scholar
Lee PY, Costumbrado J, Hsu C-Y, Kim YH. Agarose gel electrophoresis for the separation of DNA fragments. J Vis Exp 2012;20(62):3923. doi: 10.3791/3923LeePYCostumbradoJHsuC-YKimYHAgarose gel electrophoresis for the separation of DNA fragments20122062392310.3791/3923484633222546956Open DOISearch in Google Scholar
Yang B, Chen F, Hua Y, Huang S-S, Lin S, Wen L, Jiang Y. Prooxidant activities of quercetin, p-courmaric acid and their derivatives analysed by quantitative structure-activity relationship. Food Chem 2012;131:508–12. doi: 10.1016/j.foodchem.2011.09.014YangBChenFHuaYHuangS-SLinSWenLJiangYProoxidant activities of quercetin, p-courmaric acid and their derivatives analysed by quantitative structure-activity relationship20121315081210.1016/j.foodchem.2011.09.014Open DOISearch in Google Scholar
Truong DH, Nhung NTA, Dao DQ. Iron ions chelation-based antioxidant potential vs. pro-oxidant risk of ferulic acid: A DFT study in aqueous phase. Comput Theor Chem 2020;1185:112905. doi: 10.1016/j.comptc.2020.112905TruongDHNhungNTADaoDQIron ions chelation-based antioxidant potential vs2020118511290510.1016/j.comptc.2020.112905Open DOISearch in Google Scholar
Miyoshi N, Naniwa K, Yamada T, Osawa T, Nakamura Y. Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal. Arch Biochem Biophys 2007;466:274–82. doi: 10.1016/j.abb.2007.07.026MiyoshiNNaniwaKYamadaTOsawaTNakamuraYDietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal20074662748210.1016/j.abb.2007.07.02617870050Open DOISearch in Google Scholar