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Cytotoxic activity of strawberry tree (Arbutus unedo L.) honey, its extract, and homogentisic acid on CAL 27, HepG2, and Caco-2 cell lines

Andreja Jurič
Andreja Jurič
, 
Ana Huđek Turković
Ana Huđek Turković
, 
Irena Brčić Karačonji
Irena Brčić Karačonji
, 
Saša Prđun
Saša Prđun
, 
Dragan Bubalo
Dragan Bubalo
 e 
Ksenija Durgo
Ksenija Durgo
   | 07 lug 2022
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Article Category: Original article
Pubblicato online: 07 lug 2022
Pagine: 158 - 168
Ricevuto: 01 apr 2022
Accettato: 01 mag 2022
DOI: https://doi.org/10.2478/aiht-2022-73-3653
© 2022 Andreja Jurič, Ana Huđek Turković, Irena Brčić Karačonji, Saša Prđun, Dragan Bubalo, and Ksenija Durgo, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Figure 1

Cell viability of CAL 27 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). # P<0.05 vs all AFH concentrations
Cell viability of CAL 27 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). # P<0.05 vs all AFH concentrations

Figure 2

Cell viability of HepG2 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH)* P<0.05 vs other STH concentrations. # P<0.05 vs all AFH concentrations. & P<0.05 vs all HGA concentrations
Cell viability of HepG2 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH)* P<0.05 vs other STH concentrations. # P<0.05 vs all AFH concentrations. & P<0.05 vs all HGA concentrations

Figure 3

Cell viability of Caco-2 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). * P<0.05 vs all STH concentrations. # P<0.05 vs all AFH concentrations
Cell viability of Caco-2 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). * P<0.05 vs all STH concentrations. # P<0.05 vs all AFH concentrations

Figure 4

ROS induction in CAL 27 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). # P<0.05 vs all AFH concentrations. $ P<0.05 vs all STHE and HGA Concentrations. & P<0.05 vs other HGA concentrations
ROS induction in CAL 27 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). # P<0.05 vs all AFH concentrations. $ P<0.05 vs all STHE and HGA Concentrations. & P<0.05 vs other HGA concentrations

Figure 5

ROS induction in HepG2 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). * P<0.05 vs all STH concentrations. # P<0.05 vs all AFH concentrations
ROS induction in HepG2 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). * P<0.05 vs all STH concentrations. # P<0.05 vs all AFH concentrations

Figure 6

ROS induction in Caco-2 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). * P<0.05 vs all STH concentrations. # P<0.05 vs all AFH concentrations
ROS induction in Caco-2 cells after 30 min, 1 h, and 2 h of treatment with strawberry tree honey (STH), strawberry tree honey extract (STHE), homogentisic acid (HGA), and artificial honey (AFH). * P<0.05 vs all STH concentrations. # P<0.05 vs all AFH concentrations

Experimental design

Experimental group Tested concentrations*#
0.5 × 1 × 2.5 × 5 ×
AHF – Artificial honey (g/L) 0.35 0.71 1.77 3.5
STH – Strawberry tree honey (g/L) 0.35 0.71 1.77 3.5
STHE – Strawberry tree honey extract (mg/L) 1.25 2.5 6.25 12.5
HGA – Homogentisic acid (mg/L) 0.107 0.214 0.535 1.07
Exposure
30 min 1 h 2 h
Cell cultures
HepG2 Caco-2 CAL 27
eISSN:
1848-6312
Lingue:
Inglese, Slovenian
Frequenza di pubblicazione:
4 volte all'anno
Argomenti della rivista:
Medicina, Scienze medicali di base, altro
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