Docetaxel |
prolongs drug action, increases drug potency, improves water solubility |
39 |
Mytomicin C |
participates in the formation of an alkylating compound during reaction with target |
40 |
Rivastigmine, neostigmine, physostigmine, pyridostigmine |
key element for interaction with the target |
38 |
Ritonavir, amprenavir, atazanavir, darunavir |
improves drug bioavailability and potency, engaged in a backbone interaction with protease |
8 |
Ombitasvir, elbasvir, daclatasavir |
improves drug stability and lipophilicity |
41 |
Febendazole, mebendazole, febantel, albendazole |
improves aqueous solubility and bioavailability, increases cytotoxicity |
42 |
Mehocarabamol, metaxalone |
inhibits acetylcholinesterase at synapses in the autonomic nervous system, neuromuscular junction, and central nervous system |
43 |
Felbamate |
improves drug stability and bioavailability |
44, 45 |
Retigabine |
major pharmacophore responsible for interacting with residues in the KCNQ2–5 channels |
46 |
Gabapentin enacarbil |
improves bioavailability |
47 |
Capecitabine |
improves selectivity and bioavailability |
47 |
Bambuterol |
delays first-pass metabolism |
47 |
Irinotecan |
improves aqueous solubility |
47 |