Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents
and | Dec 31, 2020
About this article
Article Category: Review
Published Online: Dec 31, 2020
Page range: 285 - 299
Received: Jul 01, 2020
Accepted: Dec 01, 2020
DOI: https://doi.org/10.2478/aiht-2020-71-3466
© 2020 Ana Matošević, Anita Bosak, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Roles of the carbamate moiety in drugs and prodrugs
| Drug | The role of the carbamate moiety in the drug | Reference |
|---|---|---|
| Docetaxel | prolongs drug action, increases drug potency, improves water solubility | |
| Mytomicin C | participates in the formation of an alkylating compound during reaction with target | |
| Rivastigmine, neostigmine, physostigmine, pyridostigmine | key element for interaction with the target | |
| Ritonavir, amprenavir, atazanavir, darunavir | improves drug bioavailability and potency, engaged in a backbone interaction with protease | |
| Ombitasvir, elbasvir, daclatasavir | improves drug stability and lipophilicity | |
| Febendazole, mebendazole, febantel, albendazole | improves aqueous solubility and bioavailability, increases cytotoxicity | |
| Mehocarabamol, metaxalone | inhibits acetylcholinesterase at synapses in the autonomic nervous system, neuromuscular junction, and central nervous system | |
| Felbamate | improves drug stability and bioavailability | |
| Retigabine | major pharmacophore responsible for interacting with residues in the KCNQ2–5 channels | |
| Gabapentin enacarbil | improves bioavailability | |
| Capecitabine | improves selectivity and bioavailability | |
| Bambuterol | delays first-pass metabolism | |
| Irinotecan | improves aqueous solubility |