<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>It is commonly pointed out that enteric microbiota have a significant impact on the behavioral and neurophysiological parameters relevant to brain-gut axis disorders. Accordingly, many data have demonstrated that probiotics can alter the central nervous system function via this gut-brain axis and commensal bacteria consumption can ameliorate stress-related neuropsychiatric disorders. Thus, modulating the enteric microbiota is increasingly considered a new therapeutic approach for these disorders, although so far there is a lack of reliable pre-clinical and clinical data confirming the usefulness of probiotics in the treatment of affective disorders. In this review, we discuss various mechanisms linking specific probiotic bacteria with behaviors related to anhedonia and the exact mechanisms of their action, including data provided by using animal models and tests. Finally, we point to potential clinical impact resulting from future studies investigating the gut-brain axis activity with respect to the efficacy of probiotic treatment of mental disorders.</p>
</abstract>

It is commonly pointed out that enteric microbiota have a significant impact on the behavioral and neurophysiological parameters relevant to brain-gut axis disorders. Accordingly, many data have demonstrated that probiotics can alter the central nervous system function via this gut-brain axis and commensal bacteria consumption can ameliorate stress-related neuropsychiatric disorders. Thus, modulating the enteric microbiota is increasingly considered a new therapeutic approach for these disorders, although so far there is a lack of reliable pre-clinical and clinical data confirming the usefulness of probiotics in the treatment of affective disorders. In this review, we discuss various mechanisms linking specific probiotic bacteria with behaviors related to anhedonia and the exact mechanisms of their action, including data provided by using animal models and tests. Finally, we point to potential clinical impact resulting from future studies investigating the gut-brain axis activity with respect to the efficacy of probiotic treatment of mental disorders.

What do experimental animal models of mood disorders tell clinicians about influence of probiotics on the gut-brain axis?

Chair and Department of Pharmacology and Pharmacodynamics

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

It is commonly pointed out that enteric microbiota have a significant impact on the behavioral and neurophysiological parameters relevant to brain-gut axis...

What do experimental animal models of mood disorders tell clinicians about influence of probiotics on the gut-brain axis?

Article Category: Review

Pubblicato online: 12 set 2022

Pagine: 380 - 394

Ricevuto: 22 dic 2021

Accettato: 20 apr 2022

DOI: https://doi.org/10.2478/ahem-2022-0042

Parole chiave
probiotics, anhedonia, gut-brain axis, animal models, chronic stress

© 2022 Natasza Staniak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

What do experimental animal models of mood disorders tell clinicians about influence of probiotics on the gut-brain axis?

Article Category: Review

Pubblicato online: 12 set 2022

Pagine: 380 - 394

Ricevuto: 22 dic 2021

Accettato: 20 apr 2022

DOI: https://doi.org/10.2478/ahem-2022-0042

Parole chiaveprobiotics, anhedonia, gut-brain axis, animal models, chronic stress

© 2022 Natasza Staniak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Parole chiave
probiotics, anhedonia, gut-brain axis, animal models, chronic stress