1. bookVolume 76 (2022): Edizione 1 (January 2022)
Dettagli della rivista
License
Formato
Rivista
eISSN
1732-2693
Prima pubblicazione
20 Dec 2021
Frequenza di pubblicazione
1 volta all'anno
Lingue
Inglese
access type Accesso libero

Evidence of retinal arteriolar narrowing in patients with autosomal-dominant polycystic kidney disease

Pubblicato online: 27 May 2022
Volume & Edizione: Volume 76 (2022) - Edizione 1 (January 2022)
Pagine: 174 - 176
Ricevuto: 03 Mar 2021
Accettato: 17 Nov 2021
Dettagli della rivista
License
Formato
Rivista
eISSN
1732-2693
Prima pubblicazione
20 Dec 2021
Frequenza di pubblicazione
1 volta all'anno
Lingue
Inglese
Abstract Introduction

The aim of this study was to examine retinal vessels in autosomal dominant polycystic kidney disease (ADPKD) patients with normal kidney function and without diabetes mellitus.

Materials and Methods

We enrolled 39 adult individuals with ADPKD and 45 gender- and age-matched individuals as controls. A full ophthalmologic examination, including retinal vessel caliber and reactions to flicker stimulation analysis and grading of hypertensive retinopathy according to the Keith-Wagener classification, was performed.

Results

Multivariable analysis of ADPKD patients and controls, adjusted for age, gender, estimated glomerular filtration rate (e-GFR) and the presence of hypertension, revealed that ADPKD was an independent factor associated with lower arteriovenous ratio (AVR) values (by 0.069 on average, β = −0.50, p < 0.0001). The severity of hypertensive retinopathy according to the Keith-Wagener classification appeared to be more advanced in the ADPKD group than in the controls, despite the lack of vascular abnormalities, such as retinal hemorrhages, exudates, cotton wool spots or papilledema, as well as microaneurysms, which are very characteristic signs of ADPKD in other vascular beds.

Conclusions

Lower AVR values could be a specific pathophysiological ocular manifestation of systemic vasculopathy in the course of ADPKD.

Keywords

Cited reference details of the affected article

Pietrzak-Nowacka, Maria, Lejkowska, Renata, Kawa, Miłosz Piotr, Ulańczyk, Zofia, Safranow, Krzysztof, Nowacka, Barbara, Podborączyńska-Jodko, Karolina, Lubiński, Wojciech, Ciechanowski, Kazimierz, Machaliński, Bogusław and Machalińska, Anna. “Evidence of retinal arteriolar narrowing in patients with autosomal-dominant polycystic kidney disease” Postępy Higieny i Medycyny Doświadczalnej, vol.76, no.1, 2022, pp.82–90.

DOI of the original article

https://doi.org/10.2478/ahem-2022-0001

The description of the changes made

The Reference list was incorrect. The correct References list appears below.

The European Polycystic Kidney Disease Consortium. The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium. Cell. 1994; 77: 881–894. The European Polycystic Kidney Disease Consortium The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium Cell 1994 77 881 894 Search in Google Scholar

Kimberling WJ, Kumar S, Gabow PA, Kenyon JB, Connolly CJ, Somlo S Autosomal dominant polycystic kidney disease: Localization of the second gene to chromosome 4q13–q23. Genomics. 1993; 18: 467–472. KimberlingWJ KumarS GabowPA KenyonJB ConnollyCJ SomloS Autosomal dominant polycystic kidney disease: Localization of the second gene to chromosome 4q13–q23 Genomics 1993 18 467 472 Search in Google Scholar

Joly D, Hummel A, Ruello A, Knebelmann B. Ciliary function of polycystins: A new model for cystogenesis. Nephrol Dial Transplant. 2003; 18: 1689–1692. JolyD HummelA RuelloA KnebelmannB Ciliary function of polycystins: A new model for cystogenesis Nephrol Dial Transplant 2003 18 1689 1692 Search in Google Scholar

Mao Z, Xie G, Ong AC. Metabolic abnormalities in autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2015; 30: 197–203. MaoZ XieG OngAC Metabolic abnormalities in autosomal dominant polycystic kidney disease Nephrol Dial Transplant 2015 30 197 203 Search in Google Scholar

Ravine D, Gibson RN, Walker RG, Sheffield LJ, Kincaid-Smith P, Danks DM. Evaluation of ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease 1. Lancet. 1994; 343: 824–827. RavineD GibsonRN WalkerRG SheffieldLJ Kincaid-SmithP DanksDM Evaluation of ultrasonographic diagnostic criteria for autosomal dominant polycystic kidney disease 1 Lancet 1994 343 824 827 Search in Google Scholar

Yu W, Ritchie BJ, Su X, Zhou J, Meigs TE, Denker BM. Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis. Cell Signal. 2011; 23: 213–221. YuW RitchieBJ SuX ZhouJ MeigsTE DenkerBM Identification of polycystin-1 and Gα12 binding regions necessary for regulation of apoptosis Cell Signal 2011 23 213 221 Search in Google Scholar

Mosetti MA, Leonardou P, Motohara T, Kanematsu M, Armao D, Semelka RC. Autosomal dominant polycystic kidney disease: MR imaging evaluation using current techniques. J Magn Reson Imaging. 2003; 18: 210–215. MosettiMA LeonardouP MotoharaT KanematsuM ArmaoD SemelkaRC Autosomal dominant polycystic kidney disease: MR imaging evaluation using current techniques J Magn Reson Imaging 2003 18 210 215 Search in Google Scholar

Pei Y, Watnick T. Diagnosis and screening of autosomal dominant polycystic kidney disease. Adv Chronic Kidney Dis. 2010; 17: 140–152. PeiY WatnickT Diagnosis and screening of autosomal dominant polycystic kidney disease Adv Chronic Kidney Dis 2010 17 140 152 Search in Google Scholar

Chapman AB, Guay-Woodford LM, Grantham JJ, Torres VE, Bae KT, Baumgarten DA, Kenney PJ, King BFJr, Glockner JF, et al. Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort. Kidney Int. 2003; 64: 1035–1045. ChapmanAB Guay-WoodfordLM GranthamJJ TorresVE BaeKT BaumgartenDA KenneyPJ KingBFJr GlocknerJF Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort Kidney Int 2003 64 1035 1045 Search in Google Scholar

Milutinovic J, Fialkow PJ, Agodoa LY, Phillips LA, Rudd TG, Sutherland S. Clinical manifestations of autosomal dominant polycystic kidney disease in patients older than 50 years. Am J Kidney Dis. 1990; 15: 237–243. MilutinovicJ FialkowPJ AgodoaLY PhillipsLA RuddTG SutherlandS Clinical manifestations of autosomal dominant polycystic kidney disease in patients older than 50 years Am J Kidney Dis 1990 15 237 243 Search in Google Scholar

Kim K, Drummond I, Ibraghimov-Beskrovnaya O, Klinger K, Arnaout MA. Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci USA. 2000; 97: 1731–1736. KimK DrummondI Ibraghimov-BeskrovnayaO KlingerK ArnaoutMA Polycystin 1 is required for the structural integrity of blood vessels Proc Natl Acad Sci USA 2000 97 1731 1736 Search in Google Scholar

Liu D, Wang CJ, Judge DP, Halushka MK, Ni J, Habashi JP, Moslehi J, Bedja D, Gabrielson KL, Xu H, et al. A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2014; 25: 81–91. LiuD WangCJ JudgeDP HalushkaMK NiJ HabashiJP MoslehiJ BedjaD GabrielsonKL XuH A Pkd1-Fbn1 genetic interaction implicates TGF-β signaling in the pathogenesis of vascular complications in autosomal dominant polycystic kidney disease J Am Soc Nephrol 2014 25 81 91 Search in Google Scholar

Lorthioir A, Joannidès R, Rémy-Jouet I, Fréguin-Bouilland C, Iacob M, Roche C, Monteil C, Lucas D, Renet S, Audrézet MP, et al. Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans. Kidney Int. 2015; 87: 465–472. LorthioirA JoannidèsR Rémy-JouetI Fréguin-BouillandC IacobM RocheC MonteilC LucasD RenetS AudrézetMP Polycystin deficiency induces dopamine-reversible alterations in flow-mediated dilatation and vascular nitric oxide release in humans Kidney Int 2015 87 465 472 Search in Google Scholar

Raina S, Honer M, Krämer SD, Liu Y, Wang X, ., Segerer S, Wüthrich RP, Serra AL. Anti-VEGF antibody treatment accelerates polycystic kidney disease. Am J Physiol Renal Physiol. 2011; 301: F773–F783. RainaS HonerM KrämerSD LiuY WangX SegererS WüthrichRP SerraAL Anti-VEGF antibody treatment accelerates polycystic kidney disease Am J Physiol Renal Physiol 2011 301 F773 F783 Search in Google Scholar

Vogler S, Pannicke T, Hollborn M, Kolibabka M, Wiedemann P, Reichenbach A, Hammes HP, Bringmann A. Impaired purinergic regulation of the glial (Müller) cell volume in the retina of transgenic rats expressing defective polycystin-2. Neurochem Res. 2016; 41: 1784–1796 VoglerS PannickeT HollbornM KolibabkaM WiedemannP ReichenbachA HammesHP BringmannA Impaired purinergic regulation of the glial (Müller) cell volume in the retina of transgenic rats expressing defective polycystin-2 Neurochem Res 2016 41 1784 1796 Search in Google Scholar

Fu Z, Sun Y, Cakir B, Tomita Y, Huang S, Wang Z, Liu CH, Cho SS, Britton W, Kern TS, et al. Targeting neurovascular interaction in retinal disorders. Int J Mol Sci. 2020; 21: 1503. FuZ SunY CakirB TomitaY HuangS WangZ LiuCH ChoSS BrittonW KernTS Targeting neurovascular interaction in retinal disorders Int J Mol Sci 2020 21 1503 Search in Google Scholar

Kaarniranta K, Kajdanek J, Morawiec J, Pawlowska E, Blasiak J. PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality control. The significance for AMD pathogenesis. Int J Mol Sci. 2018; 19: 2317. KaarnirantaK KajdanekJ MorawiecJ PawlowskaE BlasiakJ PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality control. The significance for AMD pathogenesis Int J Mol Sci 2018 19 2317 Search in Google Scholar

Rübsam A, Parikh S, Fort PE. Role of inflammation in diabetic retinopathy. Int J Mol Sci. 2018; 19: 942. RübsamA ParikhS FortPE Role of inflammation in diabetic retinopathy Int J Mol Sci 2018 19 942 Search in Google Scholar

Ecder T. Cardiovascular complications in autosomal dominant polycystic kidney disease. Curr Hypertens Rev. 2013; 9: 2–11. EcderT Cardiovascular complications in autosomal dominant polycystic kidney disease Curr Hypertens Rev 2013 9 2 11 Search in Google Scholar

Xu HW, Yu SQ, Mei CL, Li MH. Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease. Stroke. 2011: 42: 204–206. XuHW YuSQ MeiCL LiMH Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease Stroke 2011 42 204 206 Search in Google Scholar

Gieteling EW, Rinkel GJ. Characteristics of intracranial aneurysms and subarachnoid haemorrhage in patients with polycystic kidney disease. J Neurol. 2003; 250: 418–423. GietelingEW RinkelGJ Characteristics of intracranial aneurysms and subarachnoid haemorrhage in patients with polycystic kidney disease J Neurol 2003 250 418 423 Search in Google Scholar

Keith NM, Wagener HP, Barker NW. Some different types of essential hypertension: Their course and prognosis. Am J Med Sci. 1974; 268: 336–345. KeithNM WagenerHP BarkerNW Some different types of essential hypertension: Their course and prognosis Am J Med Sci 1974 268 336 345 Search in Google Scholar

Liew G, Wang JJ, Mitchell P, Wong TY. Retinal vascular imaging: A new tool in microvascular disease research. Circ Cardiovasc Imaging. 2008; 1: 156–161. LiewG WangJJ MitchellP WongTY Retinal vascular imaging: A new tool in microvascular disease research Circ Cardiovasc Imaging 2008 1 156 161 Search in Google Scholar

Baumann M, Schwarz S, Kotliar K, von Eynatten M, Trucksaess AS, Burkhardt K, Lutz J, Heemann U, Lanzl I. Non-diabetic chronic kidney disease influences retinal microvasculature. Kidney Blood Press Res. 2009; 32: 428–433. BaumannM SchwarzS KotliarK von EynattenM TrucksaessAS BurkhardtK LutzJ HeemannU LanzlI Non-diabetic chronic kidney disease influences retinal microvasculature Kidney Blood Press Res 2009 32 428 433 Search in Google Scholar

Triantafyllou A, Anyfanti P, Gavriilaki E, Zabulis X, Gkaliagkousi E, Petidis K, Triantafyllou G, Gkolias V, Pyrpasopoulou A, Douma S. Association between retinal vessel caliber and arterial stiffness in a population comprised of normotensive to early-stage hypertensive individuals. Am J Hypertens. 2014; 27: 1472–1478. TriantafyllouA AnyfantiP GavriilakiE ZabulisX GkaliagkousiE PetidisK TriantafyllouG GkoliasV PyrpasopoulouA DoumaS Association between retinal vessel caliber and arterial stiffness in a population comprised of normotensive to early-stage hypertensive individuals Am J Hypertens 2014 27 1472 1478 Search in Google Scholar

Wong TY, Shankar A, Klein R, Klein BE, Hubbard LD. Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus. Arch Intern Med. 2005; 165: 1060–1065. WongTY ShankarA KleinR KleinBE HubbardLD Retinal arteriolar narrowing, hypertension, and subsequent risk of diabetes mellitus Arch Intern Med 2005 165 1060 1065 Search in Google Scholar

Ponto KA, Werner DJ, Wiedemer L, Laubert-Reh D, Schuster AK, Nickels S, Höhn R, Schulz A, Binder H, Beutel M, et al. Retinal vessel metrics: Normative data and their use in systemic hypertension: Results from the Gutenberg Health Study. J Hypertens. 2017; 35: 1635–1664. PontoKA WernerDJ WiedemerL Laubert-RehD SchusterAK NickelsS HöhnR SchulzA BinderH BeutelM Retinal vessel metrics: Normative data and their use in systemic hypertension: Results from the Gutenberg Health Study J Hypertens 2017 35 1635 1664 Search in Google Scholar

Pietrzak-Nowacka M, Safranow K, Byra E, Bińczak-Kuleta A, Ciechanowicz A, Ciechanowski K. Metabolic syndrome components in patients with autosomal-dominant polycystic kidney disease. Kidney Blood Press Res. 2009; 32: 405–410. Pietrzak-NowackaM SafranowK ByraE Bińczak-KuletaA CiechanowiczA CiechanowskiK Metabolic syndrome components in patients with autosomal-dominant polycystic kidney disease Kidney Blood Press Res 2009 32 405 410 Search in Google Scholar

Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care. 1998; 21: 2191–2192. LevyJC MatthewsDR HermansMP Correct homeostasis model assessment (HOMA) evaluation uses the computer program Diabetes Care 1998 21 2191 2192 Search in Google Scholar

Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, et al. CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration). A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009; 150: 604–612. LeveyAS StevensLA SchmidCH ZhangYL CastroAF3rd FeldmanHI KusekJW EggersP Van LenteF GreeneT CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) A new equation to estimate glomerular filtration rate Ann Intern Med 2009 150 604 612 Search in Google Scholar

Machalińska A, Pius-Sadowska E, Babiak K, Sałacka A, Safranow K, Kawa MP, Machaliński B. Correlation between Flicker-induced retinal vessel vasodilatation and plasma biomarkers of endothelial dysfunction in hypertensive patients. Curr Eye Res. 2018; 43: 128–134. MachalińskaA Pius-SadowskaE BabiakK SałackaA SafranowK KawaMP MachalińskiB Correlation between Flicker-induced retinal vessel vasodilatation and plasma biomarkers of endothelial dysfunction in hypertensive patients Curr Eye Res 2018 43 128 134 Search in Google Scholar

Machalińska A, Kawa MP, Babiak K, Sobuś A, Grabowicz A, Lejkowska R, Kazimierczak A, Rynio P, Safranow K, Wilk G, et al. Retinal vessel dynamic functionality in the eyes of asymptomatic patients with significant internal carotid artery stenosis. Int Angiol. 2019; 38: 230–238. MachalińskaA KawaMP BabiakK SobuśA GrabowiczA LejkowskaR KazimierczakA RynioP SafranowK WilkG Retinal vessel dynamic functionality in the eyes of asymptomatic patients with significant internal carotid artery stenosis Int Angiol 2019 38 230 238 Search in Google Scholar

Ikram MK, Ong YT, Cheung CY, Wong TY. Retinal vascular caliber measurements: Clinical significance, current knowledge and future perspectives. Ophthalmologica. 2013; 229: 125–136. IkramMK OngYT CheungCY WongTY Retinal vascular caliber measurements: Clinical significance, current knowledge and future perspectives Ophthalmologica 2013 229 125 136 Search in Google Scholar

Pose-Reino A, Gomez-Ulla F, Hayik B, Rodriguez-Fernández M, Carreira-Nouche MJ, Mosquera-González A, González-Penedo M, Gude F. Computerized measurement of retinal blood vessel calibre: Description, validation and use to determine the influence of ageing and hypertension. J Hypertens. 2005; 23: 843–850. Pose-ReinoA Gomez-UllaF HayikB Rodriguez-FernándezM Carreira-NoucheMJ Mosquera-GonzálezA González-PenedoM GudeF Computerized measurement of retinal blood vessel calibre: Description, validation and use to determine the influence of ageing and hypertension J Hypertens 2005 23 843 850 Search in Google Scholar

Liu R, Jian W, Zhao Y, Lu X, Wu Y, Duan J. Retinal oxygen saturation and vessel diameter in patients with chronic kidney disease. Acta Ophthalmol. 2021; 99: e352–e359. LiuR JianW ZhaoY LuX WuY DuanJ Retinal oxygen saturation and vessel diameter in patients with chronic kidney disease Acta Ophthalmol 2021 99 e352 e359 Search in Google Scholar

Cai Y, Anyatonwu G, Okuhara D, Lee KB, Yu Z, Onoe T, Mei CL, Qian Q, Geng L, Wiztgall R, et al. Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812. J Biol Chem. 2004; 279: 19987–19995. CaiY AnyatonwuG OkuharaD LeeKB YuZ OnoeT MeiCL QianQ GengL WiztgallR Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812 J Biol Chem 2004 279 19987 19995 Search in Google Scholar

King BF, Torres VE, Brummer ME, Chapman AB, Bae KT, Glockner JF, Arya K, Felmlee JP, Grantham JJ, Guay-Woodford LM, et al. Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease. Kidney Int. 2003; 64: 2214–2221. KingBF TorresVE BrummerME ChapmanAB BaeKT GlocknerJF AryaK FelmleeJP GranthamJJ Guay-WoodfordLM Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease Kidney Int 2003 64 2214 2221 Search in Google Scholar

Ureña J, Fernández-Tenorio M, Porras-González C, González-Rodríguez P, Castellano A, López-Barneo J. A new metabotropic role for L-type Ca2+ channels in vascular smooth muscle contraction. Curr Vasc Pharmacol. 2013; 11: 490–496. UreñaJ Fernández-TenorioM Porras-GonzálezC González-RodríguezP CastellanoA López-BarneoJ A new metabotropic role for L-type Ca2+ channels in vascular smooth muscle contraction Curr Vasc Pharmacol 2013 11 490 496 Search in Google Scholar

Curtis TM, Scholfield C, McGeown DJ. Calcium signaling in ocular arterioles. Crit Rev Eukaryot Gene Expr. 2007; 17: 1–12. CurtisTM ScholfieldC McGeownDJ Calcium signaling in ocular arterioles Crit Rev Eukaryot Gene Expr 2007 17 1 12 Search in Google Scholar

Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature. 2000; 408: 990–994. HanaokaK QianF BolettaA BhuniaAK PiontekK TsiokasL SukhatmeVP GugginoWB GerminoGG Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents Nature 2000 408 990 994 Search in Google Scholar

Kur J, McGahon MK, Fernández JA, Scholfield CN, McGeown JG, Curtis TM. Role of ion channels and subcellular Ca2+ signaling in arachidonic acid-induced dilation of pressurized retinal arterioles. Invest Ophthalmol Vis Sci. 2014; 55: 2893–2902. KurJ McGahonMK FernándezJA ScholfieldCN McGeownJG CurtisTM Role of ion channels and subcellular Ca2+ signaling in arachidonic acid-induced dilation of pressurized retinal arterioles Invest Ophthalmol Vis Sci 2014 55 2893 2902 Search in Google Scholar

Yue Z, Xie J, Yu AS, Stock J, Du J, Yue L. Role of TRP channels in the cardiovascular system. Am J Physiol Heart Circ Physiol. 2015; 308: H157–H182. YueZ XieJ YuAS StockJ DuJ YueL Role of TRP channels in the cardiovascular system Am J Physiol Heart Circ Physiol 2015 308 H157 H182 Search in Google Scholar

Yanda MK, Liu Q, Cebotaru V, Guggino WB, Cebotaru L. Role of calcium in adult onset polycystic kidney disease. Cell Signal. 2019; 53: 140–150. YandaMK LiuQ CebotaruV GugginoWB CebotaruL Role of calcium in adult onset polycystic kidney disease Cell Signal 2019 53 140 150 Search in Google Scholar

Qian Q, Hunter LW, Li M, Marin-Padilla M, Prakash YS, Somlo S, Harris PC, Torres VE, Sieck GC. Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells. Hum Mol Genet. 2003; 12: 1875–1880. QianQ HunterLW LiM Marin-PadillaM PrakashYS SomloS HarrisPC TorresVE SieckGC Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells Hum Mol Genet 2003 12 1875 1880 Search in Google Scholar

Brill AL, Ehrlich BE. Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD. Cell Signal. 2020; 66: 109490. BrillAL EhrlichBE Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKD Cell Signal 2020 66 109490 Search in Google Scholar

Pietrzak-Nowacka M, Safranow K, Bober J, Olszewska M, Birkenfeld B, Nowosiad M, Ciechanowski K. Calcium-phosphate metabolism parameters and erythrocyte Ca2+ concentration in autosomal dominant polycystic kidney disease patients with normal renal function. Arch Med Sci. 2013; 9: 837–842. Pietrzak-NowackaM SafranowK BoberJ OlszewskaM BirkenfeldB NowosiadM CiechanowskiK Calcium-phosphate metabolism parameters and erythrocyte Ca2+ concentration in autosomal dominant polycystic kidney disease patients with normal renal function Arch Med Sci 2013 9 837 842 Search in Google Scholar

Coban M, Inci A, Yılmaz U, Asilturk E. The association of fibroblast growth factor 23 with arterial stiffness and atherosclerosis in patients with autosomal dominant polycystic kidney disease. Kidney Blood Press Res. 2018; 43: 1160–1173. CobanM InciA YılmazU AsilturkE The association of fibroblast growth factor 23 with arterial stiffness and atherosclerosis in patients with autosomal dominant polycystic kidney disease Kidney Blood Press Res 2018 43 1160 1173 Search in Google Scholar

Choi HM, Kwon YE, Kim S, Oh DJ. Changes in FGF-23, neutrophil/platelet activation markers, and angiogenin in advanced chronic kidney disease and their effect on arterial stiffness. Kidney Blood Press Res. 2019; 44: 1166–1178. ChoiHM KwonYE KimS OhDJ Changes in FGF-23, neutrophil/platelet activation markers, and angiogenin in advanced chronic kidney disease and their effect on arterial stiffness Kidney Blood Press Res 2019 44 1166 1178 Search in Google Scholar

Li Y, Holtzclaw LA, Russell JT. Müller cell Ca2+ waves evoked by purinergic receptor agonists in slices of rat retina. J Neurophysiol. 2001; 85: 986–994. LiY HoltzclawLA RussellJT Müller cell Ca2+ waves evoked by purinergic receptor agonists in slices of rat retina J Neurophysiol 2001 85 986 994 Search in Google Scholar

Milenkovic I, Weick M, Wiedemann P, Reichenbach A, Bringmann A. P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: Dependence on EGF and PDGF receptor transactivation. Invest Ophthalmol Vis Sci. 2003; 44: 1211–1220. MilenkovicI WeickM WiedemannP ReichenbachA BringmannA P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: Dependence on EGF and PDGF receptor transactivation Invest Ophthalmol Vis Sci 2003 44 1211 1220 Search in Google Scholar

Articoli consigliati da Trend MD

Pianifica la tua conferenza remota con Sciendo