| Methylene blue dye |
Intraoperatively |
INTRAOPERATIVELY identification of the SLNs stained with blue dye |
- Availability- Low cost- Very low rate of allergic reactions- No nuclear facilities required |
- Rapid loss of visibility of the marker in the presence of large amount of adipose tissue or significant intraoperative bleeding- Rapid lymphatic transportation tracker- Staining of primary tumor- Alteration of absorption of the laser energy- Possible extravasation of the dye in the surgical field |
| 99mTc-labelled radiotracer |
Preoperatively |
PREOPERATIVELY conventional lymphoscintigraphy INTRAOPERATIVELY by gamma-probe |
- Most investigated technique- Possibility of small surgical incision- Lack of primary tumor staining |
- Subject to shine through phenomenon- Requires nuclear facilities- High cost- Low sensitivity in case of SCC of the floor of the mouth |
| Indocyanine green |
Preoperatively |
INTRAOPERATIVELY NIR fluorescence imagining system |
- Possibility of small surgical incision (percutaneous visualization)- Lack of primary tumor staining |
- Limited clinical experience in OSCC- Rapid lymphatic transportation tracker- High cost |
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