<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are generally well tolerated as monotherapy. Statins are associated with two important adverse effects, asymptomatic elevation in liver enzymes and myopathy. Myopathy is most likely to occur when statins are administered with other drugs. Statins are substrates of multiple drug transporters (including OAT- -P1B1, BCRP and MDR1) and several cytochrome P450 (CYP) enzymes (including CYP3A4, CYP2C8, CYP2C19, and CYP2C9). Possible adverse effects of statins can occur due to interactions in concomitant use of drugs that substantially inhibit or induce their methabolic pathway. This review summarizes the most important interactions of statins.</p></abstract>

The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are generally well tolerated as monotherapy. Statins are associated with two important adverse effects, asymptomatic elevation in liver enzymes and myopathy. Myopathy is most likely to occur when statins are administered with other drugs. Statins are substrates of multiple drug transporters (including OAT- -P1B1, BCRP and MDR1) and several cytochrome P450 (CYP) enzymes (including CYP3A4, CYP2C8, CYP2C19, and CYP2C9). Possible adverse effects of statins can occur due to interactions in concomitant use of drugs that substantially inhibit or induce their methabolic pathway. This review summarizes the most important interactions of statins.

Drug interactions with statins

Bosnalijek, Pharmaceutical and Chemical Industry, Joint Stock Company, arajevo Bosnia and Herzegovina

Faculty of Pharmacy University of Sarajevo, Sarajevo Bosnia and Herzegovina

Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo Bosnia and Herzegovina

Acta Pharmaceutica

{"article-title":"Drug interactions with statins"}

The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are generally well tolerated as monotherapy. Statins are associated with two...

Drug interactions with statins

Pubblicato online: 22 ott 2013

Pagine: 277 - 293

DOI: https://doi.org/10.2478/acph-2013-0022

Parole chiave
statins, drug interactions, cytochrome P450 (CYP) enzymes, drug transporters, adverse effects

This content is open access.

Drug interactions with statins

Pubblicato online: 22 ott 2013

Pagine: 277 - 293

DOI: https://doi.org/10.2478/acph-2013-0022

Parole chiavestatins, drug interactions, cytochrome P450 (CYP) enzymes, drug transporters, adverse effects

This content is open access.

Parole chiave
statins, drug interactions, cytochrome P450 (CYP) enzymes, drug transporters, adverse effects