Cytogenetic characteristics of and prognosis for acute myeloid leukemia in 107 children
, e | 30 apr 2021
Article Category: Original article
Pubblicato online: 30 apr 2021
Pagine: 79 - 89
DOI: https://doi.org/10.2478/abm-2021-0010
Parole chiave
© 2021 Wanzi Chen et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
Patients diagnosed with acute myeloid leukemia (AML) in childhood have a poor prognosis. A better understanding of prognostic factors will assist patients and clinicians in making difficult treatment decisions.
Objectives
To understand further the cytogenetic characteristics of and reassess the prognostic value of cytogenetic abnormalities in childhood AML.
Methods
Conventional karyotypes of 107 children with AML were analyzed retrospectively. The cases were divided into 4 groups based on genetic rearrangements; namely patients with: t(15;17)/
Results
All French-American-British (FAB) subtypes of AML were detected in 107 patients. We successfully cultured 81 of 107 bone marrow specimens, of which 60 cases had abnormal karyotypes. The most common abnormal karyotypes were t(8;21) (17/81 cases), followed by t(15;17) (13/81 cases), –X/Y (10/81 cases). There were no significant differences (
Conclusions
Chromosomal abnormalities may provide important prognostic factors for AML in children and be helpful for risk stratification and individual treatment.