<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A blood group antigen is a protein or carbohydrate on the outer surface of a RBC. Portions of DNA are transcribed and translated into proteins. A protein-based blood group antigen is the direct product of a gene whereas a carbohydrate-based blood group antigen is an indirect product of a gene; the gene product is a glycosyltransferase that transfers a carbohydrate moiety to a protein, or to another carbohydrate to form a chain of sugars. This report gives a brief description of a gene, its processing from DNA through RNA to an amino acid sequence, and how changes in nucleotides give rise to blood group antigens. <italic><bold>Immunohematology</bold></italic><bold> 2008;24:166–169.</bold></p></abstract>

A blood group antigen is a protein or carbohydrate on the outer surface of a RBC. Portions of DNA are transcribed and translated into proteins. A protein-based blood group antigen is the direct product of a gene whereas a carbohydrate-based blood group antigen is an indirect product of a gene; the gene product is a glycosyltransferase that transfers a carbohydrate moiety to a protein, or to another carbohydrate to form a chain of sugars. This report gives a brief description of a gene, its processing from DNA through RNA to an amino acid sequence, and how changes in nucleotides give rise to blood group antigens. Immunohematology 2008;24:166–169.

From DNA to blood groups

Immunohematology

{"article-title":"From DNA to blood groups"}

A blood group antigen is a protein or carbohydrate on the outer surface of a RBC. Portions of DNA are transcribed and translated into proteins. A protein-based...

From DNA to blood groups

Article Category: Report

Pubblicato online: 25 mar 2020

Pagine: 165 - 169

DOI: https://doi.org/10.21307/immunohematology-2019-293

Parole chiave
application of molecular testing for blood groups in transfusion medicine, blood group alleles, blood group antigens, DNA to protein, prediction of blood groups

© 2008 M.E. Reid, published by Sciendo

From DNA to blood groups

Article Category: Report

Pubblicato online: 25 mar 2020

Pagine: 165 - 169

DOI: https://doi.org/10.21307/immunohematology-2019-293

Parole chiaveapplication of molecular testing for blood groups in transfusion medicine, blood group alleles, blood group antigens, DNA to protein, prediction of blood groups

© 2008 M.E. Reid, published by Sciendo

Parole chiave
application of molecular testing for blood groups in transfusion medicine, blood group alleles, blood group antigens, DNA to protein, prediction of blood groups