<abstract xmlns="http://www.w3.org/1999/xhtml"><p>A blood group antigen is a protein or carbohydrate on the outer surface of a RBC. Portions of DNA are transcribed and translated into proteins. A protein-based blood group antigen is the direct product of a gene whereas a carbohydrate-based blood group antigen is an indirect product of a gene; the gene product is a glycosyltransferase that transfers a carbohydrate moiety to a protein, or to another carbohydrate to form a chain of sugars. This report gives a brief description of a gene, its processing from DNA through RNA to an amino acid sequence, and how changes in nucleotides give rise to blood group antigens. <italic><bold>Immunohematology</bold></italic><bold> 2008;24:166–169.</bold></p></abstract>

A blood group antigen is a protein or carbohydrate on the outer surface of a RBC. Portions of DNA are transcribed and translated into proteins. A protein-based blood group antigen is the direct product of a gene whereas a carbohydrate-based blood group antigen is an indirect product of a gene; the gene product is a glycosyltransferase that transfers a carbohydrate moiety to a protein, or to another carbohydrate to form a chain of sugars. This report gives a brief description of a gene, its processing from DNA through RNA to an amino acid sequence, and how changes in nucleotides give rise to blood group antigens. Immunohematology 2008;24:166–169.

From DNA to blood groups

Immunohematology

{"article-title":"From DNA to blood groups"}

A blood group antigen is a protein or carbohydrate on the outer surface of a RBC. Portions of DNA are transcribed and translated into proteins. A protein-based...

From DNA to blood groups

Article Category: Report

Published Online: Mar 25, 2020

Page range: 165 - 169

DOI: https://doi.org/10.21307/immunohematology-2019-293

Keywords
application of molecular testing for blood groups in transfusion medicine, blood group alleles, blood group antigens, DNA to protein, prediction of blood groups

© 2008 M.E. Reid, published by Sciendo

From DNA to blood groups

Article Category: Report

Published Online: Mar 25, 2020

Page range: 165 - 169

DOI: https://doi.org/10.21307/immunohematology-2019-293

Keywordsapplication of molecular testing for blood groups in transfusion medicine, blood group alleles, blood group antigens, DNA to protein, prediction of blood groups

© 2008 M.E. Reid, published by Sciendo

Keywords
application of molecular testing for blood groups in transfusion medicine, blood group alleles, blood group antigens, DNA to protein, prediction of blood groups