<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The adequate performance and correct interpretation of assays for coagulation factor inhibitors play a critical role for the hemostasis laboratory. Both, false positive and false negative inhibitor assays may be reported, leading to erroneous patient’s management. Therefore, we decided to present a case with a spurious image of an exceptionally rare acquired combined haemophilia A, B and C, with severe factor ( F) VIII, IX and XI deficiency, associated with high titre anti - F VIII, IX and XI inhibitors in a 4 years old girl with Henoch-Schönlein type vasculitis. Finally, performing, beside coagulometric methods also antigenic ELISA assays, we had to invalidate the diagnosis. The performance of antiphospholipd antibodies clarified the diagnosis , finally concluding as definite diagnosis Transient Lupus Anticoagulant Syndrome, with decisive impact on therapy and follow-up.</p></abstract>

The adequate performance and correct interpretation of assays for coagulation factor inhibitors play a critical role for the hemostasis laboratory. Both, false positive and false negative inhibitor assays may be reported, leading to erroneous patient’s management. Therefore, we decided to present a case with a spurious image of an exceptionally rare acquired combined haemophilia A, B and C, with severe factor ( F) VIII, IX and XI deficiency, associated with high titre anti - F VIII, IX and XI inhibitors in a 4 years old girl with Henoch-Schönlein type vasculitis. Finally, performing, beside coagulometric methods also antigenic ELISA assays, we had to invalidate the diagnosis. The performance of antiphospholipd antibodies clarified the diagnosis , finally concluding as definite diagnosis Transient Lupus Anticoagulant Syndrome, with decisive impact on therapy and follow-up.

Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The adequate performance and correct interpretation of assays for coagulation factor inhibitors play a critical role for the hemostasis laboratory. Both, false...

Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis

Article Category: Case Report

Pubblicato online: 01 ago 2017

Pagine: 295 - 300

Ricevuto: 04 mag 2017

Accettato: 10 lug 2017

DOI: https://doi.org/10.1515/rrlm-2017-0026

Parole chiave
acquired haemophilia, lupus anticoagulant, Henoch-Schönlein vasculitis, children, antiphospholipid antibody syndrome

© by Margit Serban

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Pitfalls in hemostasis exploration, a case report of a girl with Henoch-Schönlein type vasculitis

Article Category: Case Report

Pubblicato online: 01 ago 2017

Pagine: 295 - 300

Ricevuto: 04 mag 2017

Accettato: 10 lug 2017

DOI: https://doi.org/10.1515/rrlm-2017-0026

Parole chiaveacquired haemophilia, lupus anticoagulant, Henoch-Schönlein vasculitis, children, antiphospholipid antibody syndrome

© by Margit Serban

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Parole chiave
acquired haemophilia, lupus anticoagulant, Henoch-Schönlein vasculitis, children, antiphospholipid antibody syndrome