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Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 gene on lipid profile and adipokines levels in obese subjects

E Becer
E Becer
 e 
A Çırakoğlu
A Çırakoğlu
   | 30 giu 2017
Balkan Journal of Medical Genetics's Cover Image
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Article Category: Original Article
Pubblicato online: 30 giu 2017
Pagine: 71 - 80
DOI: https://doi.org/10.1515/bjmg-2017-0007
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© 2017 Becer E, Çırakoğlu A
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Genotype and allele frequencies of the PPARγ2 Pro12Ala polymorphism compared between obese and non obese subjects. [Results are given as n (%)].

Obese Subjects (n = 160) Non Obese Subjects (n = 140) p Value

The p value was analyzed by the χ2 test.
Genotype
   PP (wild-type) 98 (61.25) 81 (57.86)
   PA (heterozygous) 43 (26.875) 49 (35.00)
   AA (homozygous) 19 (11.875) 10 (7.14) 0.17
Allele frequency
   P 239 (74 69) 211 (75 36)
   A 81 (25.31) 69 (24.64) 0.92

Baseline characteristics of the studied populations.

Parameters Obese Subjects (n = 160) Non Obese Subjects (n = 140) p Value
Age 41.40 ± 8.19 39.6.0 ± 9.63 0.081
BMI (kg/m2) 34.12 ± 6.84 21.56 ± 4.65 <0.001
Waist circumference (cm) 111.50 ± 14.36 84.73 ± 7.39 <0.001
Hip circumference (cm) 122.10 ± 15.94 97.49 ± 6.72 <0.001
Fasting glucose (mg/dL) 104.22 ± 19.38 88.45 ± 8.39 <0.001
Total cholesterol (mg/dL) 236.35 ± 31.73 207.12 ± 33.50 <0.001
LDL-cholesterol (mg/dL) 138.90 ± 27.36 118.23 ± 25.17 <0.001
HDL-cholesterol (mg/dL) 47.63 ± 8.41 56.82 ± 7.29 <0.001
Triglycerides (mg/dL) 156.30 ± 37.71 105.10 ± 31.90 <0.001
HOMA-IR 4.25 ± 1.78 1.89 ± 0.42 <0.001
Leptin (ng/mL) 21.42 ± 8.65 7.82 ± 2.53 <0.001
Adiponectin (ng/mL) 7.81 ± 2.84 16.32 ± 7.22 <0.001
Resistin (ng/mL) 8.59 ± 2.36 5.28 ± 2.34 <0.001
Chemerin (ng/mL) 186.40 ± 22.17 138.20 ± 25.76 <0.001

Anthropometric and metabolic characteristics across PPARγ2 Pro12Ala genotypes of obese and non obese subjects. (Data are expressed as means ± SD. For comparison of the subgroups, ANOVA was performed.)

Parameters Obese Subjects Non Obese Subjects
PP (n = 98) PA ( n = 43) AA (n = 19) p Value PP (n = 81) PA(n = 49) AA (n = 10) p Value
Age 40.71 ± 6.53 42.20 ± 8.92 41.50 ± 8.34 0.540 38.90 ± 7.23 40.10 ± 8.72 39.70 ± 8.67 0.690
BMI (kg/m2) 33.46 ± 4.31 34.42 ± 6.94 34.53 ± 5.28 0.500 20.64 ± 3.67 21.37 ± 2.51 22.53 ± 2.84 0.150
Waist circumference (cm) 111.74 ± 11.32 110.62 ± 11.47 111.95 ± 10.94 0.850 83.75 ± 8.59 85.46 ± 8.73 84.92 ± 6.48 0.530
Hip circumference (cm) 118.33 ± 14.20 122.49 ± 15.48 125.35 ± 16.53 0.091 96.33 ± 5.12 98.62 ± 6.93 97.41 ± 6.84 0.106
Fasting glucose (mg/dL) 101.50 ± 18.34 105.31 ± 16.52 107.53 ± 18.78 0.270 89.58 ± 7.49 87.64 ± 8.30 88.23 ± 8.16 0.380
Total cholesterol (mg/dL) 228.70 ± 33.51 235.29 ± 32.38 240.58 ± 33.17 0.260 198.95 ± 30.10 209.32 ± 27.56 212.86 ± 31.68 0.091
LDL-cholesterol (mg/dL) 132.60 ± 35.80 139.91 ± 26.20 141.96 ± 30.74 0.326 116.83 ± 22.30 119.64 ± 25.48 118.82 ± 24.90 0.800
HDL-cholesterol (mg/dL) 49.38 ± 8.87 47.54 ± 8.21 46.63 ± 7.93 0.290 57.84 ± 7.72 56.83 ± 8.29 54.38 ± 8.46 0.150
Triglycerides (mg/dL) 146.12 ± 37.20 158.85 ± 35.52 164.60 ± 36.14

Significant difference from PP genotype by the post hoc Tukey test.

 0.046 100.38 ± 32.00 104.42 ± 30.20 111.17 ± 35.11 0.520
Leptin (ng/mL) 17.47 ± 8.36 20.31 ± 8.62 26.39 ± 9.15

Significant difference from PP genotype by the post hoc Tukey test.

 <0.001 6.15 ± 2.64

Significant difference between PA genotype and AA genotype by the post hoc Tukey test

 7.53 ± 3.18 9.58 ± 2.23 <0.001
Adiponectin (µg/mL) 8.73 ± 2.75 7.81 ± 2.90 6.78 ± 2.28

Significant difference between PA genotype and PP genotype by the post hoc Tukey test.

 0.010 18.58 ± 8.92 15.59 ± 7.34 14.64 ± 7.69 0.086
Resistin (ng/mL) 6.74 ± 2.73

Significant difference from PP genotype by the post hoc Tukey test.

 8.82 ± 2.46 9.89 ± 3.25 <0.001 4.73 ± 2.11 5.42 ± 2.53 5.65 ± 2.77 0.180
Chemerin (ng/mL) 176.52 ± 23.80

Significant difference between PA genotype and AA genotype by the post hoc Tukey test.

 186.79 ± 22.30 194.81 ± 22.74 0.002 130.55 ± 22.40 137.69 ± 21.20 145.83 ± 22.31

Significant difference between PA genotype and AA genotype by the post hoc Tukey test.

 0.047
HOMA-IR 4.05 ± 2.27 4.11 ± 1.92 4.63 ± 1.62 0.290 1.86 ± 0.73 1.84 ± 0.61 1.95 ± 0.52 0.650
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