Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 gene on lipid profile and adipokines levels in obese subjects
und | 30. Juni 2017
Über diesen Artikel
Article Category: Original Article
Online veröffentlicht: 30. Juni 2017
Seitenbereich: 71 - 80
DOI: https://doi.org/10.1515/bjmg-2017-0007
Schlüsselwörter
© 2017 Becer E, Çırakoğlu A
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Genotype and allele frequencies of the PPARγ2 Pro12Ala polymorphism compared between obese and non obese subjects. [Results are given as n (%)].
| Obese Subjects ( |
Non Obese Subjects ( |
The |
|
|---|---|---|---|
| Genotype | |||
| PP (wild-type) | 98 (61.25) | 81 (57.86) | |
| PA (heterozygous) | 43 (26.875) | 49 (35.00) | |
| AA (homozygous) | 19 (11.875) | 10 (7.14) | 0.17 |
| Allele frequency | |||
| P | 239 (74 69) | 211 (75 36) | |
| A | 81 (25.31) | 69 (24.64) | 0.92 |
Baseline characteristics of the studied populations.
| Parameters | Obese Subjects ( |
Non Obese Subjects ( |
|
|---|---|---|---|
| Age | 41.40 ± 8.19 | 39.6.0 ± 9.63 | 0.081 |
| BMI (kg/m2) | 34.12 ± 6.84 | 21.56 ± 4.65 | <0.001 |
| Waist circumference (cm) | 111.50 ± 14.36 | 84.73 ± 7.39 | <0.001 |
| Hip circumference (cm) | 122.10 ± 15.94 | 97.49 ± 6.72 | <0.001 |
| Fasting glucose (mg/dL) | 104.22 ± 19.38 | 88.45 ± 8.39 | <0.001 |
| Total cholesterol (mg/dL) | 236.35 ± 31.73 | 207.12 ± 33.50 | <0.001 |
| LDL-cholesterol (mg/dL) | 138.90 ± 27.36 | 118.23 ± 25.17 | <0.001 |
| HDL-cholesterol (mg/dL) | 47.63 ± 8.41 | 56.82 ± 7.29 | <0.001 |
| Triglycerides (mg/dL) | 156.30 ± 37.71 | 105.10 ± 31.90 | <0.001 |
| HOMA-IR | 4.25 ± 1.78 | 1.89 ± 0.42 | <0.001 |
| Leptin (ng/mL) | 21.42 ± 8.65 | 7.82 ± 2.53 | <0.001 |
| Adiponectin (ng/mL) | 7.81 ± 2.84 | 16.32 ± 7.22 | <0.001 |
| Resistin (ng/mL) | 8.59 ± 2.36 | 5.28 ± 2.34 | <0.001 |
| Chemerin (ng/mL) | 186.40 ± 22.17 | 138.20 ± 25.76 | <0.001 |
Anthropometric and metabolic characteristics across PPARγ2 Pro12Ala genotypes of obese and non obese subjects. (Data are expressed as means ± SD. For comparison of the subgroups, ANOVA was performed.)
| Parameters | Obese Subjects | Non Obese Subjects | ||||||
|---|---|---|---|---|---|---|---|---|
| PP (n = 98) | PA ( |
AA (n = 19) | PP (n = 81) | PA(n = 49) | AA (n = 10) | |||
| Age | 40.71 ± 6.53 | 42.20 ± 8.92 | 41.50 ± 8.34 | 0.540 | 38.90 ± 7.23 | 40.10 ± 8.72 | 39.70 ± 8.67 | 0.690 |
| BMI (kg/m2) | 33.46 ± 4.31 | 34.42 ± 6.94 | 34.53 ± 5.28 | 0.500 | 20.64 ± 3.67 | 21.37 ± 2.51 | 22.53 ± 2.84 | 0.150 |
| Waist circumference (cm) | 111.74 ± 11.32 | 110.62 ± 11.47 | 111.95 ± 10.94 | 0.850 | 83.75 ± 8.59 | 85.46 ± 8.73 | 84.92 ± 6.48 | 0.530 |
| Hip circumference (cm) | 118.33 ± 14.20 | 122.49 ± 15.48 | 125.35 ± 16.53 | 0.091 | 96.33 ± 5.12 | 98.62 ± 6.93 | 97.41 ± 6.84 | 0.106 |
| Fasting glucose (mg/dL) | 101.50 ± 18.34 | 105.31 ± 16.52 | 107.53 ± 18.78 | 0.270 | 89.58 ± 7.49 | 87.64 ± 8.30 | 88.23 ± 8.16 | 0.380 |
| Total cholesterol (mg/dL) | 228.70 ± 33.51 | 235.29 ± 32.38 | 240.58 ± 33.17 | 0.260 | 198.95 ± 30.10 | 209.32 ± 27.56 | 212.86 ± 31.68 | 0.091 |
| LDL-cholesterol (mg/dL) | 132.60 ± 35.80 | 139.91 ± 26.20 | 141.96 ± 30.74 | 0.326 | 116.83 ± 22.30 | 119.64 ± 25.48 | 118.82 ± 24.90 | 0.800 |
| HDL-cholesterol (mg/dL) | 49.38 ± 8.87 | 47.54 ± 8.21 | 46.63 ± 7.93 | 0.290 | 57.84 ± 7.72 | 56.83 ± 8.29 | 54.38 ± 8.46 | 0.150 |
| Triglycerides (mg/dL) | 146.12 ± 37.20 | 158.85 ± 35.52 | 164.60 ± 36.14 Significant difference from PP genotype by the |
0.046 | 100.38 ± 32.00 | 104.42 ± 30.20 | 111.17 ± 35.11 | 0.520 |
| Leptin (ng/mL) | 17.47 ± 8.36 | 20.31 ± 8.62 | 26.39 ± 9.15 Significant difference from PP genotype by the |
<0.001 | 6.15 ± 2.64 Significant difference between PA genotype and AA genotype by the |
7.53 ± 3.18 | 9.58 ± 2.23 | <0.001 |
| Adiponectin (µg/mL) | 8.73 ± 2.75 | 7.81 ± 2.90 | 6.78 ± 2.28 Significant difference between PA genotype and PP genotype by the |
0.010 | 18.58 ± 8.92 | 15.59 ± 7.34 | 14.64 ± 7.69 | 0.086 |
| Resistin (ng/mL) | 6.74 ± 2.73 Significant difference from PP genotype by the |
8.82 ± 2.46 | 9.89 ± 3.25 | <0.001 | 4.73 ± 2.11 | 5.42 ± 2.53 | 5.65 ± 2.77 | 0.180 |
| Chemerin (ng/mL) | 176.52 ± 23.80 Significant difference between PA genotype and AA genotype by the |
186.79 ± 22.30 | 194.81 ± 22.74 | 0.002 | 130.55 ± 22.40 | 137.69 ± 21.20 | 145.83 ± 22.31 Significant difference between PA genotype and AA genotype by the |
0.047 |
| HOMA-IR | 4.05 ± 2.27 | 4.11 ± 1.92 | 4.63 ± 1.62 | 0.290 | 1.86 ± 0.73 | 1.84 ± 0.61 | 1.95 ± 0.52 | 0.650 |