<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2015-0001_s_001"><h3>Aim</h3><p>The aim of this article is to review criticaly the Electrical Status Epilepticus in Slow Sleep (ESES) phenomenon from a neurophysiological mechanisms aspect as well as terminological and classification issues.</p></sec><sec id="j_joepi-2015-0001_s_002"><h3>Methods</h3><p>The review includes all the relevant papers published during the last 43 years on the subject of ESES and Continous Spike – Wave in Sleep (CSWS).These papers were identified in various large databases via the internet.</p></sec><sec id="j_joepi-2015-0001_s_003"><h3>Rewiev and remarks</h3><p>ESES/CSWS phenomena can be held as a common final pathway originating from different etiologies, including patients with early brain damage (probably involving thalamic structures), but also patients without structural pathology as in atypical evolution of idiopathic regional childhood hyperexcitability syndromes (with Rolandic epilepsy as a prototype). There are hints that genetic predisposition might be an important factor in the development of this process. The two large patient groups (lesional and non-lesional) show the same EEG evolution and encephalopathic cognitive consequences. The sleep EEG activation can be held as a common endophenotype. ESES represents an extreme sleep activation/potentiation of the local/regional interictal discharges, enhancing them in frequency, territorial extension, intra and trans-hemispherial propagation, synchrony and continuity. This process is most probably not identical with the development of bilateral spike-wave pattern in ,,generalized” epilepsies which involves primarily or secondarily the thalamocortical system as it had been explored by Gloor (1979) for idiopathic generalized rpilepsy and Steriade and Amzica (2003) for different types of generalized spike and wave discharges.</p></sec><sec id="j_joepi-2015-0001_s_004"><h3>Conclusions and syndromological embedding of ESES</h3><p>In an overwhelming majority of the investigated cases, the maps of the single discharges constituting sleep activation are identical; with focal/regional interictal spikes followed by slow closing wave, as it is seen in childhood regional age dependent hyperexcitability syndromes (prototype of the centro-temporal spikes of Rolandic epilepsy). The main mechanism of the developing cognitive impairment is most probably the consequence of interference with plastic function of slow wave sleep by obliterating synaptic decline during sleep. Presently, the consensus and co-operative research is highly obstacled by the terminological chaos, the controversial definitions and views around this still striking and enigmatic phenomenon.</p></sec></abstract>

Encephalopathy with Electrical Status Epilepticus in Slow Wave Sleep – a review with an emphasis on regional (perisylvian) aspects

<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2015-0016_s_001"><h3>Introduction</h3><p>Cognitive dysfunction is one of the main comorbidities of epilepsy which co-exists with seizures and contributes to the adverse impact of the disease on employment, education and interpersonal relationships. A fundamental question regarding cognitive dysfunction in epilepsy goes as follows: in comparison to seizures, what role does cognitive dysfunction play in causing social disability? The purpose of this review was to evaluate our understanding of the role cognitive impairment plays in social disability in persons with epilepsy (PWE). We systematically searched the medical literature and identified studies which assessed the impact of seizures and cognitive function on some aspect of social disability in PWE.</p></sec><sec id="j_joepi-2015-0016_s_002"><h3>Results and Discussion</h3><p>We identified 12 studies which adequately measured all variables in non-surgical cohorts, and 9 studies of cohorts following epilepsy surgery. We found evidence from non-surgical and from surgical series that cognitive variables strongly correlate with levels of social disability.</p></sec><sec id="j_joepi-2015-0016_s_003"><h3>Conclusions</h3><p>We conclude that efforts to better understand the origins of cognitive dysfunction in epilepsy and subsequently at developing treatment modalities will be needed in order to reduce the degree of social disability caused by the condition.</p></sec></abstract>

Cognitive impairment predicts social disability in persons with epilepsy

<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2015-0017_s_001"><h3>Introduction</h3><p>Epilepsy that is associated with neurocutaneous disorders seriously deteriorates quality of life and cognitive outcome of affected children. Recent advances in epilepsy pathophysiology raise hopes for better treatment results in this difficult group of patients.</p></sec><sec id="j_joepi-2015-0017_s_002"><h3>Aim</h3><p>The aim of this review is to present recent treatment recommendations as well as current research progress in the most frequent neurocutaneous disorders.</p></sec><sec id="j_joepi-2015-0017_s_003"><h3>Material and methods</h3><p>We analyzed PubMed database to select the most prominent and recent (up to 2014 year) publications on the treatment and mechanisms of epilepsy in selected neurocutaneous disorders. We aimed to emphasize evidence-based medicine recommendations as well as basic experimental studies dealing with molecular mechanisms of epileptogenesis.</p></sec><sec id="j_joepi-2015-0017_s_004"><h3>Discussion and conclusions</h3><p>Recent advances in disease-modifying treatment options such as mTOR inhibitors in patients with tuberous sclerosis complex open up new perspectives for neurologists. Traditional resective surgery has still a major role as a treatment of choice in carefully selected cases.</p></sec></abstract>

Recent advances in pathophysiology studies and treatment of epilepsy in neurocutaneous disorders

<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2015-0018_s_001"><h3>Background</h3><p>Monotherapy is the choice regimen to treat newly diagnosed epilepsies. However, if it fails, several strategies may be followed.</p></sec><sec id="j_joepi-2015-0018_s_002"><h3>Aim</h3><p>To discuss the treatment options when an initial monotherapy regimen fails.</p></sec><sec id="j_joepi-2015-0018_s_003"><h3>Methods</h3><p>We reviewed the relevant literature on the topic by using PubMed.</p></sec><sec id="j_joepi-2015-0018_s_004"><h3>Review and Discussion</h3><p>Approximately 64% of people with epilepsy (PWE) de novo are free of seizures with the first appropriate antiepileptic drug (AED) in monotherapy. The type (first versus second generation) of the first AED to use depends on the physician’s personal choice provided that it is a first-line AED. There is a tendency to prefer a substitution rather than a combination of a failed first AED when it was produced associated with an idiosyncratic reaction, was poorly tolerated at a moderate dose, or produced no improvement in seizure control. In contrast, there is some evidence to prefer secondary polytherapy whenever the PWE tolerate its first AED but with a suboptimal response. In this case, and particularly mainly if a first generation AED was used as a first-line treatment, I prefer to choose a new generation AED given their more favourable pharmacokinetic and pharmacodynamic profiles. A very often used strategy is transitional polytherapy between two regimens of monotherapy.</p></sec><sec id="j_joepi-2015-0018_s_005"><h3>Conclusion</h3><p>Any therapeutic decision should take into account factors such as seizure type or syndrome, possibility of drug side effects, comorbidities, comedications, age, teratogenic potential, and compliance. Whatever the option to be taken, the PWE, his family or the caregivers should take part in the decision making.</p></sec></abstract>

Failure of a first regimen of monotherapy to control the newly diagnosed epilepsies. What to do next?

<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_joepi-2015-0019_s_001"><h3>Introduction</h3><p>Dominant presentation of ictal forced repetitive swearing has been rarely addressed and could be misdiagnosed.</p></sec><sec id="j_joepi-2015-0019_s_002"><h3>Case report</h3><p>We report a 45-year-old man with a long history of right frontal lobe epilepsy (FLE) who developed forced repetitive swearing during hypermotor seizures. His seizures were refractory to different antiepileptic drugs (AEDs). Scalp video-EEG telemetry suggested a right frontal epileptic focus. Magnetic resonance imaging (MRI) suggested focal cortical dysplasia (FCD) in the right mesial frontal lobe. Intracranial implantation with video-EEG recordings confirmed seizures originating from the MRI lesion. Patient underwent right frontal lobe resection followed by seizure freedom in the last five years on a single AED. Neuropathology confirmed FCD type IIB.</p></sec><sec id="j_joepi-2015-0019_s_003"><h3>Discussion</h3><p>The following aspects of the case are discussed: FLE and ictal vocalization, swearing, FLE and aggression. We emphasize the differences among ictal vocalisation, verbal automatism and ictal speech. We propose that ictal swearing might fit a verbal automatism definition.</p></sec><sec id="j_joepi-2015-0019_s_004"><h3>Conclusion</h3><p>Ictal forced repetitive swearing can be a manifestation of hypermotor seizures in FLE and should not be misdiagnosed.</p></sec></abstract>

Ictal Forced Repetitive Swearing in Frontal Lobe Epilepsy: Case report and review of the literature

<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The stated purpose of the meeting was to summarize ,,current, new and proven approaches in diagnostics and epilepsy therapy” to define optimal clinical practice and scientific research areas, highlight advances in clinical and basic science and to identify future approaches or directions in epilepsy treatment.</p></abstract>

20<sup>th</sup> Annual Meeting of the German-Austrian-Swiss Epilepsy Working Group

AHEAD OF PRINT

Volume 31 (2023): Issue 1 (November 2023)

Volume 29 (2021): Issue 1 (July 2021)

Volume 28 (2020): Issue 1 (December 2020)

Volume 27 (2019): Issue 1 (November 2019)

Volume 26 (2018): Issue 1-2 (June 2018)

Volume 25 (2017): Issue 1-2 (December 2017)

Volume 24 (2016): Issue 2 (December 2016)

Volume 24 (2016): Issue 1 (June 2016)

Volume 23 (2015): Issue 2 (December 2015)

Volume 23 (2015): Issue 1 (June 2015)

Volume 22 (2014): Issue 2 (December 2014)

Volume 22 (2014): Issue 1 (June 2014)

Volume 21 (2013): Issue 2 (December 2013)

Volume 21 (2013): Issue 1 (June 2013)

Journal of Epileptology

 The Journal of Epileptology – published since 2013 - is an international, open access peer reviewed scientific journal that publishes articles of clinical and experimental epilepsy.   The following categories of epilepsy related topics are accepted for publications: medical hypotheses, basic research, clinical research, reviews and special reports, product investigation, diagnostic and medical technology, case reports, letters to Editor, reports from international and local activities.   The aim of the journal is to widen the international community of readers, research and clinicians interested in various aspects of epilepsy and disseminate interdisciplinary knowledge in all fields related to epilepsy.   The Journal of Epileptology is owned by the Foundation of Epileptology which was established in 1993 by Professor Jerzy Majkowski. The Foundation of Epileptology is the first non-governmental organization in Poland whose priority is to improve the quality of life of persons with epilepsy by improving the diagnostic and therapeutic skills of doctors and by shaping a positive attitude to epilepsy among the public. The Foundation, led by this idea, brings together physicians, psychologists, scientists and academics, social activists and other people who wish to contribute to the development of epileptology and thus provide medical assistance to persons with epilepsy.     About Society   The Foundation of Epileptology was established in 1993 by Professor Jerzy Majkowski who also founded the Department of Neurology and Epileptology at the Medical Centre for Postgraduate Education (CMKP) in 1988. The Foundation of Epileptology is the first non-governmental organisation in Poland to have as its priority the improvement of quality of life of epileptic patients by means of furthering doctors' diagnostic and therapeutic mastery and developing a positive approach to epilepsy among the general public. The Foundation, led by this idea, attracts physicians, psychologists, researchers and academics, social activists and other persons who wish to contribute to the development of epileptology and thereby bring medical assistance to people suffering from epilepsy. The Foundation of Epileptology was registered in the Foundation Register of the District Court for the Municipality of Warsaw on 16 March 1993 and thereby acquired legal status. The Founder appointed the Foundation Council and the Foundation Executive Committee.   The Foundation of Epileptology co-operates with the Polish Society of Epileptology, the Warsaw-based Society for Victims of Epilepsy and their Friends "Calm Head" (Spokojna Głowa) and other domestic and foreign organisations with similar goals. The Foundation of Epileptology is a member of the European Epilepsy Academy (EUREPA) and Professor Majkowski is co-organiser and member of the first Executive Committee and is now a member of the EUREPA Research Advisory Committee. The Executive Committee of the Polish Society of Epileptology shares its headquarters with the Epilepsy Foundationv   Archiving   The archiving of issues published from 2013 to 2017 will occur, and thus all issues published in the current form of the Journal will become available on-line. However, the issues published quarterly under the journal’s earlier name of Epileptologia during 1993 to 2012 will be successively attached and published on journal’s website www.journal-epileptology.com.   Sciendo archives the contents of this journal in Portico - digital long-term preservation service of scholarly books, journals and collections.   Plagiarism Policy   The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. 

Journal of Epileptology

Volume 22 (2014): Issue 2 (December 2014)

Encephalopathy with Electrical Status Epilepticus in Slow Wave Sleep – a review with an emphasis on regional (perisylvian) aspects

Cognitive impairment predicts social disability in persons with epilepsy

Recent advances in pathophysiology studies and treatment of epilepsy in neurocutaneous disorders

Failure of a first regimen of monotherapy to control the newly diagnosed epilepsies. What to do next?

Ictal Forced Repetitive Swearing in Frontal Lobe Epilepsy: Case report and review of the literature

20^th Annual Meeting of the German-Austrian-Swiss Epilepsy Working Group

Search

All Volumes and Issues in this Journal

Journal of Epileptology

Volume 22 (2014): Issue 2 (December 2014)

Encephalopathy with Electrical Status Epilepticus in Slow Wave Sleep – a review with an emphasis on regional (perisylvian) aspects

Cognitive impairment predicts social disability in persons with epilepsy

Recent advances in pathophysiology studies and treatment of epilepsy in neurocutaneous disorders

Failure of a first regimen of monotherapy to control the newly diagnosed epilepsies. What to do next?

Ictal Forced Repetitive Swearing in Frontal Lobe Epilepsy: Case report and review of the literature

20th Annual Meeting of the German-Austrian-Swiss Epilepsy Working Group

Search

All Volumes and Issues in this Journal

20^th Annual Meeting of the German-Austrian-Swiss Epilepsy Working Group