<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: The platelet function analyzer (PFA-100) is a system analyzing platelet function determined for detection of the functional inherited and acquired platelet disorders, screening of von Willebrand disease (vWD) and recently also considered as useful for monitoring of antiplatelet treatment. The PFA-100 test uses a high shear flow system to simulate in vitro the conditions to which platelets are subjected at the site of a damaged blood vessel wall.Aim of study: We decided to establish the reference intervals of PFA closure time (CT) in the Slovak population of healthy blood donors.Patients and methods: Fifty age and gender matched healthy blood donors were enrolled in the study. We investigated the relationships between PFA-100 CT, gender and ABO blood groups.Results: The reference intervals for CT measured on CEPI (collagen/epinephrine) and CADP (collagen/adenosine diphosphate) cartridge in 3.2% citrated blood were 86 - 199 sec. and 42 - 119 sec., respectively. Blood group O was associated with significantly longer CEPI CT (p&lt;0.05) compared to non - O groups. The prolongation of CADP CT in blood donors with blood group O was without significance. The influence of gender as another variable analyzed with CT has not been evaluated as statistically significant.Conclusion: PFA-100 CT should be interpreted carefully with consideration of both the patient’s clinical presentation and laboratory variables such as ABO blood group.</abstract>

Variables That Affect Results of PFA-100 in a Group of Healthy Blood Donors in the Slovak Population

<abstract xmlns="http://www.w3.org/1999/xhtml"> Skin aging has become an area of increasing research interest in dermatovenerology. Changes in the skin associated with aging can be detected by high - frequency 20 MHz ultrasonography, which is a useful diagnostic technique allowing reliable imaging of cutaneous and superficial subcutaneous structures.Skin thickness is considered an objective parameter providing assessment of the influence of endogenous or exogenous factors, such as ultraviolet (UV) or infrared (IR) rays. Except for the changes in the skin thickness, there are also specific structural changes in the dermis of older subjects - subepidermal low echogenic band (SLEB) - that is a manifestation of photoaging severity. The main aim of this study was to identify and characterize the specific ultrasonographic changes of the cutaneous structure related to age and degree of photo exposure (the presence and measurement of SLEB).</abstract>

Identification of the Age Related Skin Changes Using High-Frequency Ultrasound

<abstract xmlns="http://www.w3.org/1999/xhtml"> Nodular amelanotic melanoma has been always a great challenge in dermatology. Because of lack of melanin pigment, tumors are diagnosed usually in advanced stage. Amelanotic melanoma can mimic basal cell carcinoma. Knowledge of typical dermoscopic structures helps to establish diagnosis and to plan surgery with appropriate safety margins. In amelanotic melanoma we can see typical vessels, white streaks or milky red globules on pink-reddish background. Vessels are typically thin and polymorphous in thick amelanotic melanoma. We had a case when vessels were polymorphous but thick. It can be confusing with nodular basal cell carcinoma where vessels are typically thick and arborizing. Nodular basal cell carcinoma is the most common form of basal cell carcinoma. Dermoscopy is a valuable tool for the diagnosis of basal cell carcinoma. Typical dermoscopic structures are arborizing vessels, possible sites of ulceration and/or pigmentation. We describe a case report of patient with typical dermoscopic structures seen in nodular basal cell carcinoma.</abstract>

Dermoscopy as a Valuable Tool in Diagnosis of Nodular Amelanotic Melanoma and Nodular Basal Cell Carcinoma

<abstract xmlns="http://www.w3.org/1999/xhtml"> Internal malignancy may be presented in the form of paraneoplastic syndromes, which may indicate either formation or recurrence of a previously treated malignancy. Furthermore cutaneous paraneoplastic disorders often precede a diagnosis of cancer. We present 2 unique case reports with cutaneous paraneoplastic manifestations. The first one describes a patient with sudden progression of long-term stabilized morphea in connection with newly diagnosed hepatocellular carcinoma (HCC). The second one describes female patient with breast cancer preceded by the development of extragenital lichen sclerosus (LS) with typical sclerotic lesions and hemorrhagic bullae.</abstract>

Cutaneous Paraneoplastic Manifestation (Morphea, Lichen Sclerosus) – Two Case Reports

<abstract xmlns="http://www.w3.org/1999/xhtml"> The authors describe a case of a rare infectious disease of intra-articular tissues of the temporomandibular joint caused mainly by Pseudomonas aeruginosa. In scientific literature, under the heading invasive (malignant) external otitis, we can find cases of an infectious disease of the external acoustic meatus caused by a microbial agent of Pseudomonas aeruginosa which can subsequently penetrate into structures. However, a primary affliction of the abovementioned structures has not been described. Localisation and severity of the infection requires long-term and massive treatment with antibiotics.</abstract>

Pseudomonas Infection of the Temporomandibular Joint (TMJ) Health and Public Health Issues

AHEAD OF PRINT

Volume 24 (2024): Issue 1 (April 2024)

Volume 23 (2023): Issue 3 (December 2023)

Volume 23 (2023): Issue 2 (August 2023)

Volume 23 (2023): Issue 1 (April 2023)

Volume 22 (2022): Issue 3 (December 2022)

Volume 22 (2022): Issue 2 (August 2022)

Volume 22 (2022): Issue 1 (April 2022)

Volume 21 (2021): Issue 3 (December 2021)

Volume 21 (2021): Issue 2 (August 2021)

Volume 21 (2021): Issue 1 (March 2021)

Volume 20 (2020): Issue 3 (December 2020)

Volume 20 (2020): Issue 2 (August 2020)

Volume 20 (2020): Issue 1 (April 2020)

Volume 19 (2019): Issue 3 (December 2019)

Volume 19 (2019): Issue 2 (August 2019)

Volume 19 (2019): Issue 1 (April 2019)

Volume 18 (2018): Issue 3 (December 2018)

Volume 18 (2018): Issue 2 (August 2018)

Volume 18 (2018): Issue 1 (June 2018)

Volume 17 (2017): Issue 3 (December 2017)

Volume 17 (2017): Issue 2 (August 2017)

Volume 17 (2017): Issue 1 (April 2017)

Volume 16 (2016): Issue 3 (December 2016)

Volume 16 (2016): Issue 2 (August 2016)

Volume 16 (2016): Issue 1 (April 2016)

Volume 15 (2015): Issue 3 (December 2015)

Volume 15 (2015): Issue 2 (September 2015)

Volume 15 (2015): Issue 1 (May 2015)

Volume 14 (2014): Issue 2 (September 2014)

Volume 14 (2014): Issue 1 (May 2014)

Volume 13 (2014): Issue 3 (February 2014)

Volume 13 (2013): Issue 2 (November 2013)

Volume 13 (2013): Issue 1 (March 2013)

Volume 13 (2013): Issue Supplement-1 (March 2013)

Volume 12 (2012): Issue Supplement-1 (February 2012)

Volume 12 (2012): Issue 3 (December 2012)

Volume 12 (2012): Issue 2 (August 2012)

Volume 12 (2012): Issue 1 (March 2012)

Volume 11 (2011): Issue Supplement-1 (March 2011)

Volume 11 (2011): Issue 3 (December 2011)

Volume 11 (2011): Issue 2 (August 2011)

Volume 11 (2011): Issue 1 (March 2011)

Acta Medica Martiniana

 Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. The aims and scope of the AMM:   Dissemination of research results and scientific knowledge from all areas of medicine and nursing.  Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome.   Acta Medica Martiniana (AMM) publishes, and here only in English, high quality original papers (in extenso and short-rapid communications), case reports as well as review articles.  Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.  All articles are submitted to a peer-review process. They are peer-reviewed anonymously (double blind) by external experts pursuant to the standard evaluation criteria. Based on the reviewers opinions, the Editorial Board will decide whether a paper is to be included in the journal.  Rejection Rate:   15-30%   Archiving  Sciendo archives the contents of this journal in Portico - digital long-term preservation service of scholarly books, journals and collections.  Plagiarism Policy  The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. 