<abstract xmlns="http://www.w3.org/1999/xhtml">The Initial Systolic Time Interval (ISTI), obtained from the electrocardiogram (ECG) and impedance cardiogram (ICG), is considered to be a measure for the time delay between the electrical and mechanical activity of the heart and reflects an early active period of the cardiac cycle. The clinical relevance of this time interval is subject of study. This paper introduces a method using ISTI to evaluate and predict the circulatory response to fluid administration in patients after coronary artery bypass graft surgery and presents preliminary results of a pilot study by comparing ISTI with cardiac output (CO) responsiveness. Also the use of the pulse transit time (PTT), earlier recommended for this purpose, was investigated. The results showed an inverse relationship between ISTI and CO at all moments of fluid administration and also an inverse relationship between the changes ΔISTI and ΔCO before and after full fluid administration. No relationships between PTT and CO or ΔPTT and ΔCO were found. It is concluded that ISTI is dependent upon preload, and that ISTI has the potential to be used as a clinical parameter assessing preload.</abstract>

The Initial Systolic Time Interval (ISTI), obtained from the electrocardiogram (ECG) and impedance cardiogram (ICG), is considered to be a measure for the time delay between the electrical and mechanical activity of the heart and reflects an early active period of the cardiac cycle. The clinical relevance of this time interval is subject of study. This paper introduces a method using ISTI to evaluate and predict the circulatory response to fluid administration in patients after coronary artery bypass graft surgery and presents preliminary results of a pilot study by comparing ISTI with cardiac output (CO) responsiveness. Also the use of the pulse transit time (PTT), earlier recommended for this purpose, was investigated. The results showed an inverse relationship between ISTI and CO at all moments of fluid administration and also an inverse relationship between the changes ΔISTI and ΔCO before and after full fluid administration. No relationships between PTT and CO or ΔPTT and ΔCO were found. It is concluded that ISTI is dependent upon preload, and that ISTI has the potential to be used as a clinical parameter assessing preload.

Assessing cardiac preload by the Initial Systolic Time Interval obtained from impedance cardiography

Journal of Electrical Bioimpedance

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

The Initial Systolic Time Interval (ISTI), obtained from the electrocardiogram (ECG) and impedance cardiogram (ICG), is considered to be a measure for the time...

Assessing cardiac preload by the Initial Systolic Time Interval obtained from impedance cardiography

Article Category: Articles

Publié en ligne: 10 déc. 2010

Pages: 80 - 83

Reçu: 04 nov. 2010

DOI: https://doi.org/10.5617/jeb.141

Mots clés
Bioimpedance, impedance cardiography, initial systolic time interval, cardiac preload, coronary artery bypass graft surgery

© 2010 Jan H. Meijer, Annemieke Smorenberg, Erik J. Lust, Rudolf M. Verdaasdonk and A. B. Johan Groeneveld , published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Assessing cardiac preload by the Initial Systolic Time Interval obtained from impedance cardiography

Article Category: Articles

Publié en ligne: 10 déc. 2010

Pages: 80 - 83

Reçu: 04 nov. 2010

DOI: https://doi.org/10.5617/jeb.141

Mots clésBioimpedance, impedance cardiography, initial systolic time interval, cardiac preload, coronary artery bypass graft surgery

© 2010 Jan H. Meijer, Annemieke Smorenberg, Erik J. Lust, Rudolf M. Verdaasdonk and A. B. Johan Groeneveld , published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
Bioimpedance, impedance cardiography, initial systolic time interval, cardiac preload, coronary artery bypass graft surgery