<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with <italic>Encephalomyocarditis virus</italic> (<italic>EMCV</italic>). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to <italic>EMCV</italic> infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.</p>
</abstract>

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.

Antiviral Resistance of Splenocytes in Aged Mice

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Antiviral Resistance of Splenocytes in Aged Mice"}

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin...

Antiviral Resistance of Splenocytes in Aged Mice

Publié en ligne: 30 mars 2017

Pages: 131 - 134

Reçu: 03 déc. 2015

Accepté: 04 janv. 2017

DOI: https://doi.org/10.5604/pjm-2017-131

Mots clés
immune ageing, lactoferrin, mice, splenocytes, viral resistance

© 2017 EWA ZACZYŃSKA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antiviral Resistance of Splenocytes in Aged Mice

Publié en ligne: 30 mars 2017

Pages: 131 - 134

Reçu: 03 déc. 2015

Accepté: 04 janv. 2017

DOI: https://doi.org/10.5604/pjm-2017-131

Mots clésimmune ageing, lactoferrin, mice, splenocytes, viral resistance

© 2017 EWA ZACZYŃSKA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
immune ageing, lactoferrin, mice, splenocytes, viral resistance