<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with <italic>Encephalomyocarditis virus</italic> (<italic>EMCV</italic>). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to <italic>EMCV</italic> infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.</p>
</abstract>

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.

Antiviral Resistance of Splenocytes in Aged Mice

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Antiviral Resistance of Splenocytes in Aged Mice"}

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin...

Antiviral Resistance of Splenocytes in Aged Mice

Publicado en línea: 30 mar 2017

Páginas: 131 - 134

Recibido: 03 dic 2015

Aceptado: 04 ene 2017

DOI: https://doi.org/10.5604/pjm-2017-131

Palabras clave
immune ageing, lactoferrin, mice, splenocytes, viral resistance

© 2017 EWA ZACZYŃSKA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Antiviral Resistance of Splenocytes in Aged Mice

Publicado en línea: 30 mar 2017

Páginas: 131 - 134

Recibido: 03 dic 2015

Aceptado: 04 ene 2017

DOI: https://doi.org/10.5604/pjm-2017-131

Palabras claveimmune ageing, lactoferrin, mice, splenocytes, viral resistance

© 2017 EWA ZACZYŃSKA et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
immune ageing, lactoferrin, mice, splenocytes, viral resistance