Does portal vein anatomy influence intrahepatic distribution of metastases from colorectal cancer?

Figure 1.

Figure 2.

Figure 3.

Predominance of right portal vein (RPV) or left portal vein (LPV) and intrahepatic distribution of colorectal liver metastasis (CRLM)

Characteristics	Predominant RPV N = 123 (67%)a,b,c	Predominant LPV N = 61 (33%)a,b,c	p-valued
Distribution of CRLM
Bilateral	67 (54)	33 (54)
Right unilateral	43 (35)	18 (30)
Left unilateral	13 (11)	10 (16)
Number of segments involved (right liver)	2 (1–3)	2 (1–3)	0.60
Number of segments involved (left liver)	1 (0–2)	1 (0–2)	0.70
Total number of CRLM	3 (1–8)	4 (1–5)	0.70
Number of CRLM in the right liver	2 (1–5)	2 (1–4)	0.40
Number of CRLM in the left liver	1 (0–3)	1 (0–2)	0.60
Ratio number of CRLM right/left liver	1 (1.0–3.0)	1 (1.0–2.0)	0.70
Ratio number of CRLM per segment (right liver)	1 (1.0–2.0)	1 (1.0–2.0)	0.60
Ratio number of CRLM per segment (left liver)	1 (1.0–1.8)	1 (1.0–2.0)	> 0.90

Bilateral, right and left unilateral distribution of colorectal liver metastases and vascular anatomy

Characteristics	Overall, N = 200a	Bilateral N =110 (55%)a	Right unilateral N = 66 (33%)a	Left unilateral N = 24 (12%)a	P-valueb
Patient
Age (years)	64 (57–71)	63 (53–70)	65 (58–74)	67 (63–71)	0.02
Gender: female	81 (41)	47 (43)	29 (44)	5 (21)	0.11
BMI (kg/m2)	24 (21.0–27.0)	24 (21.0–27.0)	24 (22.0–26.0)	24 (23.0–27.3)	0.70
Primitive tumor location					0.60
Right colon	34 (17)	16 (15)	12 (18)	6 (25)
Left colon	112 (57)	60 (56)	38 (58)	14 (58)
Rectum	52 (26)	32 (30)	16 (24)	4 (17)
T stage					0.60
0–2	31 (18)	15 (17)	10 (17)	6 (26)
3–4	139 (82)	74 (83)	48 (83)	17 (74)
N stage					0.80
0	66 (40)	33 (38)	23 (43)	10 (43)
1–2	98 (60)	55 (63)	30 (57)	13 (57)
KRAS mutation	60 (30)	33 (30)	20 (30)	7 (29)	> 0.90
BRAF mutation	6 (3)	4 (3.6)	2 (3)	0 (0)	> 0.90
MSI	4 (2)	2 (1.8)	1 (1.5)	1 (4.2)	0.60
Number of CRLM	3 (1–7)	6 (4–11)	1 (1–3)	1 (1–1)	< 0.01
Synchronous CRLM	140 (70)	87 (79)	38 (58)	15 (63)	0.01
Vascular
PV variations					0.13
Type 1	156 (78)	88 (80)	51 (77)	17 (71)
Type 2	19 (9,5)	13 (12)	3 (4.5)	3 (13)
Type 3	25 (13)	9 (8.2)	12 (18)	4 (17)
PV diameter
Main trunk	13.5 (12.4–15)	13.3 (12.4–15)	13.7 (12.50–15)	13.8 (12.15–14.20	>
RPV	11.3 (10.0–12.9)	11.4 (10.0–13.0)	11.3 (10.0–12.6)	11.3 (10.3–12.1)	0.90
LPV	10.7 (9.6–12.0)	10.7 (9.6–12.0)	10.5 (9.0–11.9)	10.9 (10.1–12.0)	0.50
Ratio diameter RPV/LPV	1.1 (0.9–1.2)	1.1 (0.9–1.2)	1.1 (1.0–1.3)	1.1 (0.9–1.2)	0.40
PV branches angulation
RPV	153 (142–163)	151 (140–162)	155 (145–168)	158 (147–164)	0.20
LPV	97 (80–115)	98 (77–113)	97 (81–118)	98 (84–116)	0.80
Predominant PV branchc				0.50
RPV	123 (67)	67 (67)	43(70)	13 (57)
LPV	61 (33)	33 (33)	18(30)	10 (43)
Arterial variations
Right hepatic artery	22 (11)	13 (12)	8 (12)	1 (4.2)	0.70
Left hepatic artery	24 (12)	12 (11)	8 (12)	4 (17)	0.70

Unilateral right and left distribution of colorectal liver metastases and portal anatomy

Characteristics,	Right unilateral, N = 66 (73%)a	Left unilateral, N = 24 (27%)a	p-valueb
Number of CRLM	1 (1–3)	1 (1–1)	0.03
PV variations
Type 1	51 (77)	17 (71)
Type 2	3 (4.5)	3 (13)
Type 3	12 (18)	4 (17)
PV diameter
Main trunk	13.7 (12.5–15.0)	13.8 (12.2–14.2)	0.70
RPV	11.3 (10.0–12.6)	11.3 (10.3–12.1)	0.60
LPV	10.5 (9.0–11.9)	10.9 (10.1–12)	0.20
Ratio diameter RPV/LPV	1.1 (1.0–1.3)	1.1 (0.9–1.2)	0.20
PV branches angulation
RPV	155 (145–168)	158 (147–164)	> 0.90
LPV	97 (81–118)	98 (84–116)	0.90
Predominant PVc			0.30
RPV	43 (70)	13 (57)
LPV	18 (30)	10 (43)

Location of primary colorectal cancer and intrahepatic distribution of colorectal cancer liver metastases

–	Right colon N = 33 (19%)a	Left colon N = 142 (81%)a	p-valueb
Distribution of CRLM
Bilateral	16 (49)	79 (56)
Right unilateral	11 (33)	47 (33)
Left unilateral	6 (18)	16 (11)
Number of CRLM	2 (1–6)	3 (1–8)	0.20
Number of CRLM in the right liver	1 (1–3)	2 (1–5)	0.12
Number of CRLM in the left liver	1 (0–2)	1 (0–3)	0.70
Ratio number of CRLM right/left liver	1 (1–1)	1 (1–3)	0.20