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Radiology and Oncology
Édition 56 (2022): Edition 2 (June 2022)
Accès libre
Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity
Vesna Todorovic
Vesna Todorovic
,
Blaz Groselj
Blaz Groselj
,
Maja Cemazar
Maja Cemazar
,
Ajda Prevc
Ajda Prevc
,
Martina Niksic Zakelj
Martina Niksic Zakelj
,
Primoz Strojan
Primoz Strojan
et
Gregor Sersa
Gregor Sersa
| 07 avr. 2022
Radiology and Oncology
Édition 56 (2022): Edition 2 (June 2022)
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Article Category:
Research Article
Publié en ligne:
07 avr. 2022
Pages:
173 - 184
Reçu:
25 févr. 2022
Accepté:
16 mars 2022
DOI:
https://doi.org/10.2478/raon-2022-0014
© 2022 Vesna Todorovic, Blaz Groselj, Maja Cemazar, Ajda Prevc, Martina Niksic Zakelj, Primoz Strojan, Gregor Sersa, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Figure 1
Overall expression of DNA-damage signaling genes in (parental, HPV-negative) FaDu cells and (HPV-positive) 2A3 cells after exposure to cisplatin (CDDP), radiation (IR) or their combination (CDDP+IR). Symbols are mean gene expression for each of the 84 DNA-damage signaling genes included on the Human DNA Damage Signaling Pathway RT2 ProfilerTM PCR Array from 3 independent experiments. The lines indicate the median gene expression of all tested genes.* p < 0.05; *** p < 0.001; **** p < 0.0001
Figure 2
2-D clustergram analysis of the expression of DNA-damage signaling genes in (parental, HPV-negative) FaDu cells and (HPV-positive) 2A3 cells after exposure to cisplatin (CDDP), radiation (IR) or their combination (CDDP+IR). Clusters observed at ¼ dendrogram branch height are shown as blocks of different color.
Figure 3
Deregulated expression of DNA-damage signaling genes in (parental, HPV-negative) FaDu cells and (HPV-positive) 2A3 cells after exposure to cisplatin (CDDP), radiation (IR) or their combination (CDDP+IR). Only significantly deregulated genes are shown. Symbols are the mean and SEM from three independent experiments.* p < 0.05; ** p < 0.01; *** p < 0.001
Figure 4
Overall gene expression in (parental, HPV-negative) FaDu cells and (radioresistant) FaDu-RR cells in response to cisplatin (CDDP) and bleomycin (BLEO). Symbols are mean gene expression for each of the 84 DNA-damage signaling genes included on the Human DNA Damage Signaling Pathway RT2 ProfilerTM PCR Array from 3 independent experiments. The lines indicate the median gene expression of all tested genes.* p < 0.05; *** p < 0.001; **** p < 0.0001
Figure 5
2-D clustergram analysis of the expression of DNA-damage signaling genes in (parental) FaDu cells and (radioresistant) FaDu-RR cells after exposure to cisplatin (CDDP) or bleomycin (BLEO). Clusters observed at ¼ dendrogram branch height are shown as blocks of different color.
Figure 6
Deregulated expression of DNA-damage signaling genes in (parental) FaDu cells and (radioresistant) FaDu-RR cells after exposure to cisplatin (CDDP) or bleomycin (BLEO). Only significantly deregulated genes are shown. Symbols are the mean and SEM from three independent experiments.* p < 0.05
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