The influence of genetic variability in IL1B and MIR146A on the risk of pleural plaques and malignant mesothelioma
, , , , et | 21 oct. 2020
À propos de cet article
Article Category: Research Article
Publié en ligne: 21 oct. 2020
Pages: 429 - 436
Reçu: 07 juil. 2020
Accepté: 06 août 2020
DOI: https://doi.org/10.2478/raon-2020-0057
© 2020 Petra Piber, Neza Vavpetic, Katja Goricar, Vita Dolzan, Viljem Kovac, Alenka Franko, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Association between selected polymorphisms and the risk of developing malignant mesothelioma compared to pleural plaques
| SNP | Genotype | Pleural plaques | MM | OR (95 % CI) | p | OR (95 % CI)adj1 | padj1 | OR (95 % CI)adj2 | padj2 |
|---|---|---|---|---|---|---|---|---|---|
| GG | 205 (52.0) | 152 (54.9) | reference | reference | |||||
| GC | 157 (39.8) | 97 (35.0) | 0.83 (0.60–1.16) | 0.277 | 0.88 (0.61–1.27) | 0.499 | 0.67 (0.39–1.15) | 0.151 | |
| CC | 32 (8.1) | 28 (10.1) | 1.18 (0.68–2.04) | 0.554 | 1.07 (0.58–1.99) | 0.827 | 0.65 (0.22–1.86) | 0.418 | |
| GC+CC | 189 (48.0) | 125 (45.1) | 0.89 (0.66–1.21) | 0.467 | 0.92 (0.65–1.29) | 0.617 | 0.67 (0.40–1.11) | 0.123 | |
| TT | 50 (12.7) | 36 (13.0) | 1.02 (0.63–1.67) | 0.923 | 0.96 (0.56–1.67) | 0.897 | 0.54 (0.22–1.34) | 0.184 | |
| TC | 169 (42.9) | 118 (42.6) | 0.99 (0.71–1.38) | 0.969 | 0.98 (0.68–1.42) | 0.929 | 0.70 (0.41–1.19) | 0.186 | |
| CC | 175 (44.4) | 123 (44.4) | reference | reference | |||||
| TC+TT | 219 (55.6) | 154 (55.6) | 1.00 (0.73–1.36) | 0.998 | 0.98 (0.69–1.38) | 0.905 | 0.66 (0.40–1.10) | 0.110 | |
| GG | 233 (59.1) | 165 (59.6) | reference | reference | |||||
| GC | 145 (36.8) | 98 (35.4) | 0.95 (0.69–1.32) | 0.778 | 0.93 (0.65–1.34) | 0.708 | 0.92 (0.53–1.60) | 0.774 | |
| CC | 16 (4.1) | 14 (5.1) | 1.24 (0.59–2.60) | 0.578 | 1.29 (0.56–2.97) | 0.553 | |||
| GC+CC | 161 (40.9) | 112 (40.4) | 0.98 (0.72–1.34) | 0.911 | 0.97 (0.68–1.37) | 0.849 | 1.09 (0.66–1.82) | 0.731 | |
| GG | 196 (49.7) | 158 (57.0) | reference | reference | |||||
| GC | 163 (41.4) | 110 (39.7) | 0.84 (0.61–1.15) | 0.276 | 0.84 (0.58–1.20) | 0.326 | 0.65 (0.38–1.11) | 0.118 | |
| CC | 35 (8.9) | 9 (3.2) | 0.34 (0.11–1.09) | 0.069 | |||||
| GC+CC | 198 (50.3) | 119 (43.0) | 0.75 (0.55–1.02) | 0.063 | 0.74 (0.53–1.05) | 0.092 |
Characteristics of subjects included in the study
| Characteristics | Control group | Pleural plaques | Malignant mesothelioma | Test | p | |
|---|---|---|---|---|---|---|
| Male, N (%) | 119 (68.0) | 271 (68.8) | 202 (72.9) | 1.757 calculated using Fisher exact test | 0.410 | |
| Female, N (%) | 56 (32.0) | 123 (31.3) | 75 (27.1) | |||
| Median (25%–75%) | 55.3 (48.6–63.7) | 54.9 (48.8–62.7) | 66.0 (59.0–73.0) | 151.666 calculated using Kruskal-Wallis test | ||
| Low, N (%) | 134 (76.6) | 278 (71.6) [6] | 43 (48.3) [188] | 26.891 calculated using Fisher exact test | ||
| Medium, N (%) | 13 (7.4) | 41 (10.6) | 24 (27.0) | |||
| High, N (%) | 28 (16.0) | 69 (17.8) | 22 (24.7) | |||
| No, N (%) | 94 (53.7) | 194 (49.4) [1] | 150 (55.6) [7] | 2.640 calculated using Fisher exact test | 0.267 | |
| Yes, N (%) | 81 (46.3) | 199 (50.6) | 120 (44.4) |
Association between selected polymorphisms and the risk of developing malignant mesothelioma
| SNP | Genotype | Controls | MM | OR (95% CI) | p | OR (95% CI)adj1 | padj1 | OR (95% CI)adj2 | padj2 |
|---|---|---|---|---|---|---|---|---|---|
| GG | 88 (50.3) | 152 (54.9) | reference | reference | |||||
| GC | 67 (38.3) | 97 (35.0) | 0.84 (0.56–1.26) | 0.396 | 0.82 (0.52–1.29) | 0.388 | 0.56 (0.29–1.05) | 0.072 | |
| CC | 20 (11.4) | 28 (10.1) | 0.81 (0.43–1.52) | 0.514 | 0.69 (0.35–1.38) | 0.294 | 0.34 (0.11–1.04) | 0.060 | |
| GC+CC | 87 (49.7) | 125 (45.1) | 0.83 (0.57–1.22) | 0.341 | 0.79 (0.52–1.20) | 0.266 | |||
| TT | 21 (12.0) | 36 (13.0) | 1.10 (0.60–2.02) | 0.756 | 0.94 (0.48–1.82) | 0.849 | 0.53 (0.20–1.43) | 0.210 | |
| TC | 75 (42.9) | 118 (42.6) | 1.01 (0.67–1.51) | 0.960 | 0.98 (0.63–1.52) | 0.911 | 0.67 (0.36–1.24) | 0.198 | |
| CC | 79 (45.1) | 123 (44.4) | reference | reference | |||||
| TC+TT | 96 (54.9) | 154 (55.6) | 1.03 (0.70–1.51) | 0.878 | 0.97 (0.64–1.47) | 0.873 | 0.63 (0.35–1.13) | 0.122 | |
| GG | 105 (60.0) | 165 (59.6) | reference | reference | |||||
| GC | 60 (34.3) | 98 (35.4) | 1.04 (0.69–1.56) | 0.851 | 0.97 (0.62–1.51) | 0.895 | 1.00 (0.53–1.89) | 0.993 | |
| CC | 10 (5.7) | 14 (5.1) | 0.89 (0.38–2.08) | 0.789 | 0.96 (0.38–2.41) | 0.931 | 2.03 (0.70–5.90) | 0.194 | |
| GC+CC | 70 (40.0) | 112 (40.4) | 1.02 (0.69–1.50) | 0.927 | 0.97 (0.64–1.48) | 0.885 | 1.15 (0.64–2.08) | 0.632 | |
| GG | 94 (53.7) | 158 (57.0) | reference | reference | |||||
| GC | 64 (36.6) | 110 (39.7) | 1.02 (0.69–1.53) | 0.913 | 0.91 (0.59–1.41) | 0.672 | 0.67 (0.36–1.25) | 0.209 | |
| CC | 17 (9.7) | 9 (3.2) | 0.39 (0.11–1.38) | 0.144 | |||||
| GC+CC | 81 (46.3) | 119 (43.0) | 0.87 (0.60–1.28) | 0.488 | 0.79 (0.52–1.21) | 0.278 | 0.62 (0.34–1.11) | 0.109 |