Ultralow anterior resection with implantation of gentamicin-collagen sponge and no defunctioning stoma: anastomotic leakage and local cancer relapse

1Gessler B, Eriksson O, Angenete E. Diagnosis, treatment, and consequences of anastomotic leakage in colorectal surgery. Int J Colorectal Dis 2017; 32: 549-56. doi: 10.1007/s00384-016-2744-x Gessler B Eriksson O Angenete E Diagnosis, treatment, and consequences of anastomotic leakage in colorectal surgery Int J Colorectal Dis 2017 32 54956 10.1007/s00384-016-2744-xOpen DOISearch in Google Scholar

2Taflampas P, Christodoulakis M, Tsiftsis DD. Anastomotic leakage after low anterior resection for rectal cancer: facts, obscurity, and fiction. Surg Today 2009; 39: 183-8. doi: 10.1007/s00595-008-3835-2 Taflampas P Christodoulakis M Tsiftsis DD Anastomotic leakage after low anterior resection for rectal cancer: facts, obscurity, and fiction Surg Today 2009 39 1838 10.1007/s00595-008-3835-2Open DOISearch in Google Scholar

3Szynglarewicz B, Matkowski R, Forgacz J, Pudelko M, Grzebieniak Z. Anastomosis wrapping with gentamicin-containing collagen sponge in rectal cancer patients following sphincter-preserving total mesorectal excision without defunctioning stoma. Case Rep Clin Pract Rev 2006; 7: 267-71. Szynglarewicz B Matkowski R Forgacz J Pudelko M Grzebieniak Z Anastomosis wrapping with gentamicin-containing collagen sponge in rectal cancer patients following sphincter-preserving total mesorectal excision without defunctioning stoma Case Rep Clin Pract Rev 2006 7 26771Search in Google Scholar

4Szynglarewicz B, Matkowski R, Gisterek I, Włodarska-Polińska I, Kasprzak P, Sydor D, et al. Implantation of gentamicin-containing collagen sponge following anterior resection for rectal carcinoma: can it decrease the leakage risk? Colorectal Dis 2007; 9 (Suppl 3): O19. Szynglarewicz B Matkowski R Gisterek I Włodarska-Polińska I Kasprzak P Sydor D Implantation of gentamicin-containing collagen sponge following anterior resection for rectal carcinoma: can it decrease the leakage risk? Colorectal Dis 2007 9 Suppl 3 O19Search in Google Scholar

5Szynglarewicz B, Ekiert M, Forgacz J, Matkowski R. Can gentamicin-containing collagen sponge be used for the protection against leakage following low anterior resection with total mesorectal excision? Tech Coloproctol 2014; 18: 767-8. doi: 10.1007/s10151-014-1139-7 Szynglarewicz B Ekiert M Forgacz J Matkowski R Can gentamicin-containing collagen sponge be used for the protection against leakage following low anterior resection with total mesorectal excision? Tech Coloproctol 2014 18 7678 10.1007/s10151-014-1139-7Open DOISearch in Google Scholar

6Markantonis SL, Kostopanagiotou G, Panidis D, Smirniotis V, Voros D. Effects of blood loss and fluid volume replacement on serum and tissue gentamicin concentrations during colorectal surgery. Clin Ther 2004; 26: 271-81. doi: 10.1016/S0149-2918(04)90025-2 Markantonis SL Kostopanagiotou G Panidis D Smirniotis V Voros D Effects of blood loss and fluid volume replacement on serum and tissue gentamicin concentrations during colorectal surgery Clin Ther 2004 26 27181 10.1016/S0149-2918(04)90025-2Open DOISearch in Google Scholar

7Moore RD, Lietman PS, Smith CR. Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration. J Infect Dis 1987; 155: 93-9. doi: 10.1093/infdis/155.1.93 Moore RD Lietman PS Smith CR Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration J Infect Dis 1987 155 939 10.1093/infdis/155.1.93Open DOISearch in Google Scholar

8Ruszczak Z, Friess W. Collagen as a carrier for on-site delivery of antibacterial drugs. Adv Drug Deliv Rev 2003; 55: 1679-98. doi: 10.1016/j. addr.2003.08.007. Ruszczak Z Friess W Collagen as a carrier for on-site delivery of antibacterial drugs Adv Drug Deliv Rev 2003 55 167998 10.1016/j addr.2003.08.007Open DOISearch in Google Scholar

9Chvapil M. Collagen sponge: theory and practice of medical application. J Biomed Mater Res 1977; 11: 721-41. doi: 10.1002/jbm.820110508 Chvapil M Collagen sponge: theory and practice of medical application J Biomed Mater Res 1977 11 72141 10.1002/jbm.820110508Open DOISearch in Google Scholar

10Waldvogel FA. Future perspective of aminoglycoside therapy. J Antimicrob Chemother 1984; 13: 75-8. doi: 10.1093/jac/13.suppl_A.73 Waldvogel FA Future perspective of aminoglycoside therapy J Antimicrob Chemother 1984 13 758 10.1093/jac/13.suppl_A.73Open DOISearch in Google Scholar

11Anselme K, Bacques C, Charriere G, Hartmann DJ, Herbage D, Garrone R. Tissue reaction to subcutaneous implantation of collagen sponge. A historical, ultrastructural, and immunological study. J Biomed Mater Res 1990; 24: 689-703. doi: 10.1002/jbm.820240605 Anselme K Bacques C Charriere G Hartmann DJ Herbage D Garrone R Tissue reaction to subcutaneous implantation of collagen sponge. A historical, ultrastructural, and immunological study J Biomed Mater Res 1990 24 689703 10.1002/jbm.820240605Open DOISearch in Google Scholar

12Kinel FA, Ciaccio LA, Henderson SB. Sustained release preparations, XVI: Collagen as a drug carrier. Arch Pharm 1984; 317: 657-61. doi: 10.1002/ardp.19843170802 Kinel FA Ciaccio LA Henderson SB Sustained release preparations, XVI: Collagen as a drug carrier Arch Pharm 1984 317 65761 10.1002/ardp.19843170802Open DOISearch in Google Scholar

13De Bruin AFJ, Gosselink MP, van der Harst E, Rutten HJT. Local application of gentamicin collagen implants in the prophylaxis of surgical site infections following gastrointestinal surgery: a review of clinical experience. Tech Coloproctol 2010; 14: 301-10. doi: 10.1007/s10151-010-0593-0 De Bruin AFJ Gosselink MP van der Harst E Rutten HJT Local application of gentamicin collagen implants in the prophylaxis of surgical site infections following gastrointestinal surgery: a review of clinical experience Tech Coloproctol 2010 14 30110 10.1007/s10151-010-0593-0Open DOISearch in Google Scholar

14Frouws MA, Snijders HS, Malm SH, Liefers GJ, Van de Velde CJH, Neijenhuis PA, et al. Clinical relevance of a grading system for anastomotic leakage after low anterior resection: analysis from a National Cohort Database. Dis Colon Rectum 2017; 60: 706-13. doi: 10.1097/DCR.0000000000000800 Frouws MA Snijders HS Malm SH Liefers GJ Van de Velde CJH Neijenhuis PA Clinical relevance of a grading system for anastomotic leakage after low anterior resection: analysis from a National Cohort Database Dis Colon Rectum 2017 60 70613 10.1097/DCR.0000000000000800Open DOISearch in Google Scholar

15Rutkowski A, Olesiński T, Zając L, Bednarczyk M, Szpakowski M. The risk of anastomotic leakage after anterior resection – retrospective analysis of 501 rectal cancer patients operated on without protective stoma. Minerva Chir 2017; 72: 491-8. doi: 10.1001/2013.jamasurg.2 Rutkowski A Olesiński T Zając L Bednarczyk M Szpakowski M The risk of anastomotic leakage after anterior resection – retrospective analysis of 501 rectal cancer patients operated on without protective stoma Minerva Chir 2017 72 4918 10.1001/2013.jamasurg.2Open DOISearch in Google Scholar

16Snijders HS, van den Broek CB, Wouters MW, Meershoek-Klein Kranenbarg E, Wiggers T, Rutten H, et al. An increasing use of defunctioning stomas after low anterior resection for rectal cancer. Is this the way to go? Eur J Surg Oncol 2013; 39: 715-20. doi: 10.1016/j.ejso.2013.03.025 Snijders HS van den Broek CB Wouters MW Meershoek-Klein Kranenbarg E Wiggers T Rutten H An increasing use of defunctioning stomas after low anterior resection for rectal cancer. Is this the way to go? Eur J Surg Oncol 2013 39 71520 10.1016/j.ejso.2013.03.025Open DOISearch in Google Scholar

17Wang L, Gu J. Risk factors for symptomatic anastomotic leakage after low anterior resection for rectal cancer with 30 Gy/10 f/2 w preoperative radiotherapy. World J Surg 2010; 34: 1080-5. doi: 10.1007/s00268-010-0449-9 Wang L Gu J Risk factors for symptomatic anastomotic leakage after low anterior resection for rectal cancer with 30 Gy/10 f/2 w preoperative radiotherapy World J Surg 2010 34 10805 10.1007/s00268-010-0449-9Open DOISearch in Google Scholar

18Kang CY, Halabi WJ, Chaudhry OO, Nguyen V, Pigazzi A, Carmichael JC, et al. Risk factors for anastomotic leakage after anterior resection for rectal cancer. JAMA Surg 2013; 148: 65-71. doi: 10.1001/2013.jamasurg.2 Kang CY Halabi WJ Chaudhry OO Nguyen V Pigazzi A Carmichael JC Risk factors for anastomotic leakage after anterior resection for rectal cancer JAMA Surg 2013 148 6571 10.1001/2013.jamasurg.2Open DOISearch in Google Scholar

19Bennett-Guerrero E, Pappas TN, Koltun WA, Fleshman JW, Lin M, Garg J, et al. Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery. N Engl J Med 2010; 363: 1038-49. doi: 10.1056/NEJMoa1000837 Bennett-Guerrero E Pappas TN Koltun WA Fleshman JW Lin M Garg J Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery N Engl J Med 2010 363 103849 10.1056/NEJMoa1000837Open DOISearch in Google Scholar

20Rutten HJ, Nijhuis PH. Prevention of wound infection in elective colorectal surgery by local application of a gentamicin-containing collagen sponge. Eur J Surg Suppl 1997; 578: 31-5. PMID: 9167147 Rutten HJ Nijhuis PH Prevention of wound infection in elective colorectal surgery by local application of a gentamicin-containing collagen sponge Eur J Surg Suppl 1997 578 315 PMID: 9167147Search in Google Scholar

21Nowacki MP, Rutkowski A, Oledzki J, Chwalinski M. Prospective, randomized trial examining the role of gentamycin-containing collagen sponge in the reduction of postoperative morbidity in rectal cancer patients: early results and surprising outcome at 3-year follow-up. Int J Colorectal Dis 2005; 20: 114-20. doi: 10.1007/s00384-004-0632-2 Nowacki MP Rutkowski A Oledzki J Chwalinski M Prospective, randomized trial examining the role of gentamycin-containing collagen sponge in the reduction of postoperative morbidity in rectal cancer patients: early results and surprising outcome at 3-year follow-up Int J Colorectal Dis 2005 20 11420 10.1007/s00384-004-0632-2Open DOISearch in Google Scholar

22Gruessner U, Clemens M, Pahlplatz PV, Sperling P, Witte J, Rosen HR; Septocoll Study Group. Improvement of perineal wound healing by local administration of gentamicin-impregnated collagen fleeces after abdominoperineal excision of rectal cancer. Am J Surg 2001; 182: 502-9. doi: org/10.1016/S0002-9610(01)00762-0 Gruessner U Clemens M Pahlplatz PV Sperling P Witte J Rosen HR; Septocoll Study Group. Improvement of perineal wound healing by local administration of gentamicin-impregnated collagen fleeces after abdominoperineal excision of rectal cancer Am J Surg 2001 182 5029 org/10.1016/S0002-9610(01)00762-0Open DOISearch in Google Scholar

23De Bruin AFJ, Gosselink MP, Wijffels NAT, Coene PP, van der Harst E. Local gentamicin reduces perineal wound infection after radiotherapy and abdominoperineal resection. Tech Coloproctol 2008; 12: 303-7. doi: 10.1007/s10151-008-0440-8 De Bruin AFJ Gosselink MP Wijffels NAT Coene PP van der Harst E Local gentamicin reduces perineal wound infection after radiotherapy and abdominoperineal resection Tech Coloproctol 2008 12 3037 10.1007/s10151-008-0440-8Open DOISearch in Google Scholar

24Rahbari NN, Weitz J, Hohenberger W, Heald RJ, Moran B, Ulrich A, et al. Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer. Surgery 2010; 147: 339-51. doi: 10.1016/j.surg.2009.10.012 Rahbari NN Weitz J Hohenberger W Heald RJ Moran B Ulrich A Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer Surgery 2010 147 33951 10.1016/j.surg.2009.10.012Open DOISearch in Google Scholar

25Mutter D, Aprahamian M, Tiollier J, Sonzini P, Marescaux J. Evaluation of human collagen biomaterials in the healing of colonic anastomoses in dogs. Eur J Surg 1997; 163: 287-95. PMID: 9161827 Mutter D Aprahamian M Tiollier J Sonzini P Marescaux J Evaluation of human collagen biomaterials in the healing of colonic anastomoses in dogs Eur J Surg 1997 163 28795 PMID: 9161827Search in Google Scholar

26Binnebosel M, Junge K, Kaemmer DA, Krones CJ, Titkova S, Anurov M, et al. Intraperitoneally applied gentamicin increases collagen content and mechanical stability of colon anastomosis in rats. Int J Colorectal Dis 2009; 24: 433-40. doi: 10.1007/s00384-008-0614-x Binnebosel M Junge K Kaemmer DA Krones CJ Titkova S Anurov M Intraperitoneally applied gentamicin increases collagen content and mechanical stability of colon anastomosis in rats Int J Colorectal Dis 2009 24 43340 10.1007/s00384-008-0614-xOpen DOISearch in Google Scholar

27Vaneerdeweg W, Hendriks JM, Lauwers PR, Ieven M, Eyskens EJ. Effect of gentamycin-containing sponges on the healing of colonic anastomosis in a rat model of peritonitis. Eur J Surg 2000; 166: 959-62. doi: 10.1080/110241500447137 Vaneerdeweg W Hendriks JM Lauwers PR Ieven M Eyskens EJ Effect of gentamycin-containing sponges on the healing of colonic anastomosis in a rat model of peritonitis Eur J Surg 2000 166 95962 10.1080/110241500447137Open DOISearch in Google Scholar

28Wang XT, Li DG, Li L, Kong FB, Pang LM, Mai W. Meta-analysis of oncological outcome after abdominoperineal resection or low anterior resection for lower rectal cancer. Pathol Oncol Res 2015; 21: 19-27. doi: 10.1007/s12253-014-9863-x Wang XT Li DG Li L Kong FB Pang LM Mai W Meta-analysis of oncological outcome after abdominoperineal resection or low anterior resection for lower rectal cancer Pathol Oncol Res 2015 21 1927 10.1007/s12253-014-9863-xOpen DOISearch in Google Scholar

29Sammour T, Hayes IP, Jones IT, Steel MC, Faragher I, Gibbs P. Impact of anastomotic leak on recurrence and survival after colorectal cancer surgery: a BioGrid Australia analysis. ANZ J Surg 2018; 88: E6-E10. doi: 10.1111/ans.13648 Sammour T Hayes IP Jones IT Steel MC Faragher I Gibbs P Impact of anastomotic leak on recurrence and survival after colorectal cancer surgery: a BioGrid Australia analysis ANZ J Surg 2018 88 E6E10 10.1111/ans.13648Open DOISearch in Google Scholar

30Du P, Burke JP, Khoury W, Lavery IC, Kiran RP, Remzi FH, et al. Factors associated with the location of local rectal cancer recurrence and predictors of survival. Int J Colorectal Dis 2016; 31: 825-32. doi: 10.1007/s00384-016-2526-5 Du P Burke JP Khoury W Lavery IC Kiran RP Remzi FH Factors associated with the location of local rectal cancer recurrence and predictors of survival Int J Colorectal Dis 2016 31 82532 10.1007/s00384-016-2526-5Open DOISearch in Google Scholar

31Mirnezami A, Mirnezami R, Chandrakumaran K, Sasapu K, Sagar P, Finan P. Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis. Ann Surg 2011; 253: 890-9. doi: 10.1097/SLA.0b013e3182128929 Mirnezami A Mirnezami R Chandrakumaran K Sasapu K Sagar P Finan P Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis Ann Surg 2011 253 8909 10.1097/SLA.0b013e3182128929Open DOISearch in Google Scholar

32Lu ZR, Rajendran N, Lynch AC, Heriot AG, Warrier SK. Anastomotic leak after restorative resections for rectal cancer compromise cancer outcomes and survival. Dis Colon Rectum 2016; 59: 236-44. doi: 10.1097/DCR.0000000000000554 Lu ZR Rajendran N Lynch AC Heriot AG Warrier SK Anastomotic leak after restorative resections for rectal cancer compromise cancer outcomes and survival Dis Colon Rectum 2016 59 23644 10.1097/DCR.0000000000000554Open DOISearch in Google Scholar

33Wang S, Liu J, Wang S, Zhao H, Ge S, Wang W. Adverse effect of anastomotic leakage on local recurrence and survival after anterior resection for rectal cancer: a systematic review and meta-analysis. World J Surg 2017; 41: 27784. doi: 10.1007/s00268-016-3761-1 Wang S Liu J Wang S Zhao H Ge S Wang W Adverse effect of anastomotic leakage on local recurrence and survival after anterior resection for rectal cancer: a systematic review and meta-analysis World J Surg 2017 41 27784 10.1007/s00268-016-3761-1Open DOISearch in Google Scholar

34Szynglarewicz B, Grzebieniak Z, Forgacz J, Pudelko M, Rapala M. Anastomotic leakage following anterior resection and total mesorectal excision in case of rectal carcinoma- prospective evaluation of the incidence, risk factors and protective methods. Pol Przegl Chir 2006; 78: 1-12. Szynglarewicz B Grzebieniak Z Forgacz J Pudelko M Rapala M Anastomotic leakage following anterior resection and total mesorectal excision in case of rectal carcinoma- prospective evaluation of the incidence, risk factors and protective methods Pol Przegl Chir 2006 78 112Search in Google Scholar

35Szynglarewicz B, Matkowski R, Maciejczyk A, Piotr Kasprzak, Daniel Sydor, Józef Forgacz, et al. Neoadjuvant radiotherapy and anastomosis dehiscence after total mesorectal excision for stage II and III rectal cancer. Rep Pract Oncol Radiother 2007; 12: 87-93. doi: org/10.1016/S1507-1367(10)60044-2 Szynglarewicz B Matkowski R Maciejczyk A Piotr Kasprzak Daniel Sydor Józef Forgacz Neoadjuvant radiotherapy and anastomosis dehiscence after total mesorectal excision for stage II and III rectal cancer Rep Pract Oncol Radiother 2007 12 8793 org/10.1016/S1507-1367(10)60044-2Open DOISearch in Google Scholar

36Rutkowski A, Pietrzak L, Krynski J, Zajac L, Bednarczyk M, Olesinski T, et al. The gentamicin-collagen implant and the risk of distant metastases of rectal cancer following short-course radiotherapy and curative resection: the long-term outcomes of a randomized study. Int J Colorectal Dis 2018; 33: 1087-96. doi: 10.1007/s00384-018-3045-3 Rutkowski A Pietrzak L Krynski J Zajac L Bednarczyk M Olesinski T The gentamicin-collagen implant and the risk of distant metastases of rectal cancer following short-course radiotherapy and curative resection: the long-term outcomes of a randomized study Int J Colorectal Dis 2018 33 108796 10.1007/s00384-018-3045-3Open DOISearch in Google Scholar

37Lee SY, Kim CH, Kim YJ, Kim HR. Anastomotic stricture after ultralow anterior resection or intersphincteric resection for very low-lying rectal cancer. Surg Endosc 2018; 32: 660-6. doi: 10.1007/s00464-017-5718-3 Lee SY Kim CH Kim YJ Kim HR Anastomotic stricture after ultralow anterior resection or intersphincteric resection for very low-lying rectal cancer Surg Endosc 2018 32 6606 10.1007/s00464-017-5718-3Open DOISearch in Google Scholar

38Ekkarat P, Boonpipattanapong T, Tantiphlachiva K, Sangkhathat S. Factors determining low anterior resection syndrome after rectal cancer resection: A study in Thai patients. Asian J Surg 2016; 39: 225-31. doi: 10.1016/j. asjsur.2015.07.003 Ekkarat P Boonpipattanapong T Tantiphlachiva K Sangkhathat S Factors determining low anterior resection syndrome after rectal cancer resection: A study in Thai patients Asian J Surg 2016 39 22531 10.1016/j asjsur.2015.07.003Open DOISearch in Google Scholar

39Chen TY, Wiltink LM, Nout RA, Meershoek-Klein Kranenbarg E, Laurberg S, Marijnen CA, et al. Bowel function 14 years after preoperative short-course radiotherapy and total mesorectal excision for rectal cancer: report of a multicenter randomized trial. Clin Colorectal Cancer 2015; 14: 106-14. doi. org/10.1016/j.clcc.2014.12.007 Chen TY Wiltink LM Nout RA Meershoek-Klein Kranenbarg E Laurberg S Marijnen CA Bowel function 14 years after preoperative short-course radiotherapy and total mesorectal excision for rectal cancer: report of a multicenter randomized trial Clin Colorectal Cancer 2015 14 10614 org/10.1016/j.clcc.2014.12.007Open DOISearch in Google Scholar

40Emmertsen KJ, Laurberg S. Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer. Ann Surg 2012; 255: 922-8. doi: 10.1097/SLA.0b013e31824f1c21 Emmertsen KJ Laurberg S Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer Ann Surg 2012 255 9228 10.1097/SLA.0b013e31824f1c21Open DOISearch in Google Scholar