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Ultralow anterior resection with implantation of gentamicin-collagen sponge and no defunctioning stoma: anastomotic leakage and local cancer relapse

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Figure 1

Anastomosis wrapping with GCS.
Anastomosis wrapping with GCS.

Baseline characteristics

Characteristics n (%)
Gender
Female / Male 92 (58) / 66 (42)
Age (years)
Mean ± SD / median / range 67.1 ± 9.8 / 68 / 34-85
Comorbidity
Diabetes / Cardiovascular disease 13 (8) / 40 (25)
Smoking
Yes / No 87 (55) / 71 (45)
Obesity
Yes / No 31 (20) / 127 (80)
Preoperative radiotherapy
Yes / No 65 (41) / 93 (59)
Operating time (minutes)
Mean ± SD / median / range 118.9 ± 24.8 / 120 / 45-190
Level of anastomosis (cm)
Mean ± SD / median / range 5.4 ± 1.1 / 5.0 / 3-7
Blood transfusion
Yes / No 24 (15) / 134 (85)
Postoperative fever
Yes / No 9 (6) / 149 (94)
T stage
T1T2 / T3 95 (60) / 63 (40)
N status
N- / N+ 91 (58) / 67 (42)

Uni – and multivariate analysis of anastomotic leakage incidence

Patients with Univariate Multivariate
Variables leakage analysis analysis
n (%) P - value P - value
Gender
Female 2 (2.2) 0.4010 -
Male 3 (4.5)
Age
≥ 75 4 (12.5) 0.0007 0.0004
< 75 years 1 (0.8)
Diabetes
Yes 1 (7.7)
No 4 (2.8) 0.3303 -
Cardiovascular disease
Yes 1 (2.5)
No 4 (3.4) 0.7811 -
Smoking
Yes 5 (5.7)
No 0 (0) 0.0401 0.043
Obesity
Yes 2 (6.5)
No 3 (2.4) 0.2435 -
Preoperative radiotherapy
yes 3 (4.6)
no 2 (2.2) 0.4053 -
Level of anastomosis
> 5 1 (1.5)
≤ 5 cm 4 (4.3) 0.3289 -
Blood transfusion
yes 1 (4.2)
no 4 (3.0) 0.7607 -
Postoperative fever
yes 0 (0)
no 5 (3.4) 0.5765 -
T stage
T1T2 3 (3.1)
T3 2 (3.2) 0.9953 -
N status
N- 3 (3.3)
N+ 2 (3.0) 0.9119 -
eISSN:
1581-3207
Langue:
Anglais
Périodicité:
4 fois par an
Sujets de la revue:
Medicine, Clinical Medicine, Internal Medicine, Haematology, Oncology, Radiology