<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Age-related macular degeneration (AMD) is a progressive degenerative eye disease. Neovascular age-related macular degeneration (nAMD) is the advanced form of AMD characterised by abnormal growth of newly formed blood vessels in chorioidea which typically involves fluid accumulation in the retina or retinal haemorrhage, retinal epithelial detachments, hard exudate or subretinal scars. The process of angiogenesis is controlled by ocular angiogenic factors, which have enabled the development of different treatment options aimed at these factors. This review aims to compile the available information about the most commonly identified ocular angiogenic factors, uncovering their role in the pathogenesis of nAMD and assessing their application possibilities as biomarkers of disease identification and treatment.</p></abstract>

Age-related macular degeneration (AMD) is a progressive degenerative eye disease. Neovascular age-related macular degeneration (nAMD) is the advanced form of AMD characterised by abnormal growth of newly formed blood vessels in chorioidea which typically involves fluid accumulation in the retina or retinal haemorrhage, retinal epithelial detachments, hard exudate or subretinal scars. The process of angiogenesis is controlled by ocular angiogenic factors, which have enabled the development of different treatment options aimed at these factors. This review aims to compile the available information about the most commonly identified ocular angiogenic factors, uncovering their role in the pathogenesis of nAMD and assessing their application possibilities as biomarkers of disease identification and treatment.

Role of Ocular Angiogenic Factors in the Development of Neovascular Age-Related Macular Degeneration

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Age-related macular degeneration (AMD) is a progressive degenerative eye disease. Neovascular age-related macular degeneration (nAMD) is the advanced form of...

Role of Ocular Angiogenic Factors in the Development of Neovascular Age-Related Macular Degeneration

Publié en ligne: 17 juil. 2020

Pages: 159 - 164

Reçu: 10 sept. 2019

Accepté: 27 oct. 2019

DOI: https://doi.org/10.2478/prolas-2020-0026

Mots clés
angiogenic factors, biomarkers, vascular endothelial growth factor, pigment epithelium-derived factor

© 2020 Elīza Briede et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Role of Ocular Angiogenic Factors in the Development of Neovascular Age-Related Macular Degeneration

Publié en ligne: 17 juil. 2020

Pages: 159 - 164

Reçu: 10 sept. 2019

Accepté: 27 oct. 2019

DOI: https://doi.org/10.2478/prolas-2020-0026

Mots clésangiogenic factors, biomarkers, vascular endothelial growth factor, pigment epithelium-derived factor

© 2020 Elīza Briede et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
angiogenic factors, biomarkers, vascular endothelial growth factor, pigment epithelium-derived factor