<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The aim of this work is to determine the dynamics of nitrogen saturation in small laboratory animals. Nitrogen was chosen as a model gas in this study because of its availability and characteristics, as it is not metabolised and is subject to passive diffusion. By subjecting different species of animals to hyperbaric exposures of increasing time and pressure, the study aimed to identify how rapid a decompression was possible to achieve an outcome that saw 50% of the animals surviving the ensuing acute decompression sickness.</p><p>The basic parameters of hyperbaric exposure - pressure and time - made it possible to describe the saturation phenomena on the basis of partial saturation periods and to show whether a small animal organism can be considered as a single compartment model.</p></abstract>

The aim of this work is to determine the dynamics of nitrogen saturation in small laboratory animals. Nitrogen was chosen as a model gas in this study because of its availability and characteristics, as it is not metabolised and is subject to passive diffusion. By subjecting different species of animals to hyperbaric exposures of increasing time and pressure, the study aimed to identify how rapid a decompression was possible to achieve an outcome that saw 50% of the animals surviving the ensuing acute decompression sickness.The basic parameters of hyperbaric exposure - pressure and time - made it possible to describe the saturation phenomena on the basis of partial saturation periods and to show whether a small animal organism can be considered as a single compartment model.

Analysis of Species Characteristics of Laboratory Animals in Reaction to Hyperbaric Environmental Conditions

Main Library of the Medical University of Warsaw

Department of Maritime and Tropical Medicine of the Military Medical Academy

Polish Hyperbaric Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The aim of this work is to determine the dynamics of nitrogen saturation in small laboratory animals. Nitrogen was chosen as a model gas in this study because...

Analysis of Species Characteristics of Laboratory Animals in Reaction to Hyperbaric Environmental Conditions

Publié en ligne: 10 janv. 2020

Pages: 119 - 138

Accepté: 08 août 2019

DOI: https://doi.org/10.2478/phr-2019-0016

Mots clés
decompression sickness, small laboratory animals, survival rate of 50%, species specificity

© 2019 Wojciech Giermaziak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Analysis of Species Characteristics of Laboratory Animals in Reaction to Hyperbaric Environmental Conditions

Publié en ligne: 10 janv. 2020

Pages: 119 - 138

Accepté: 08 août 2019

DOI: https://doi.org/10.2478/phr-2019-0016

Mots clésdecompression sickness, small laboratory animals, survival rate of 50%, species specificity

© 2019 Wojciech Giermaziak et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
decompression sickness, small laboratory animals, survival rate of 50%, species specificity