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Allen C.N., Harpur E.S., Gray T.J.B., Hirst B.H.: Toxic effects of non-steroidal anti-inflammatory drugs in a human intestinal epithelial cell line (HCT-8) as assessed by the MTT and neutral red assays. Toxicol In Vitro 1991, 5, 183–191.AllenC.N.HarpurE.S.GrayT.J.B.HirstB.H.Toxic effects of non-steroidal anti-inflammatory drugs in a human intestinal epithelial cell line (HCT-8) as assessed by the MTT and neutral red assays19915183–19110.1016/0887-2333(91)90016-7Search in Google Scholar
Ballet J.J., Morin A., Schmitt C., Agrapart M.: Effect of isoprinosine on in vitro proliferative responses of human lymphocytes stimulated by antigen. Int J Immunopharmacol 1982, 4, 151–157.BalletJ.J.MorinA.SchmittC.AgrapartM.Effect of isoprinosine on in vitro proliferative responses of human lymphocytes stimulated by antigen19824151–15710.1016/0192-0561(82)90043-1Search in Google Scholar
Beken S., Kasper P., van der Laan J.W.: Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals. Adv Exp Med Biol. 2016, 856, 33–64.BekenS.KasperP.van derLaanJ.W.Regulatory acceptance of alternative methods in the development and approval of pharmaceuticals201685633–6410.1007/978-3-319-33826-2_3Search in Google Scholar
Bopp S.K., Lettieri T.: Comparison of four different colourimetric and fluorometric cytotoxicity assays in a zebra fish liver cell line. BMC Pharmacol 2008, 8:8.BoppS.K.LettieriT.Comparison of four different colourimetric and fluorometric cytotoxicity assays in a zebra fish liver cell line20088:810.1186/1471-2210-8-8Search in Google Scholar
Borenfreund E., Babich H., Martin-Alguacil N.: Comparisons of two in vitro cytotoxicity assays–the neutral red (NR) and tetrazolium MTT tests. Toxicol In Vitro 1988, 2, 1–6.BorenfreundE.BabichH.Martin-AlguacilN.Comparisons of two in vitro cytotoxicity assays–the neutral red (NR) and tetrazolium MTT tests198821–610.1016/0887-2333(88)90030-6Search in Google Scholar
Chiba K., Kawakami K., Tohyama K.: Simultaneous evaluation of cell viability by neutral red, MTT and crystal violet staining assays of the same cells. Toxicol In Vitro 1998, 12, 251–258.ChibaK.KawakamiK.TohyamaK.Simultaneous evaluation of cell viability by neutral red, MTT and crystal violet staining assays of the same cells199812251–25810.1016/S0887-2333(97)00107-0Search in Google Scholar
Edmondson J.M., Armstrong L.S., Martinez A.O.: A rapid and simple MTT-based spectro-photometric assay for determining drug sensitivity in monolayer cultures. J Tissue Cult Methods 1988, 11, 15–17.EdmondsonJ.M.ArmstrongL.S.MartinezA.O.A rapid and simple MTT-based spectro-photometric assay for determining drug sensitivity in monolayer cultures19881115–1710.1007/BF01404408Search in Google Scholar
Fotakis G., Timbrell J.A.: In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 2006, 5, 160, 171–177.FotakisG.TimbrellJ.A.In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride5160171–17710.1016/j.toxlet.2005.07.001Search in Google Scholar
Gonzalez R.J., Tarloff J.B.: Evaluation of hepatic sub-cellular fractions for Alamar Blue and MTT reductase activity. Toxicol In Vitro 2001, 15, 257–259.GonzalezR.J.TarloffJ.B.Evaluation of hepatic sub-cellular fractions for Alamar Blue and MTT reductase activity200115257–25910.1016/S0887-2333(01)00014-5Search in Google Scholar
Hennessy K.J., Blecha F., Pollmann D.S., Kluber E.F.: Isoprinosine and levamisole immunomodulation in artificially reared neonatal pigs. Am J Vet Res 1987, 48, 477–480.HennessyK.J.BlechaF.PollmannD.S.KluberE.F.Isoprinosine and levamisole immunomodulation in artificially reared neonatal pigs198748477–480Search in Google Scholar
Korting H.C., Schindler S., Hartinger A., Kerscher M., Angerpointner T., Maibach H.I.: MTT-assay and neutral red release (NRR)-assay: relative role in the prediction of the irritancy potential of surfactants. Proc Natl Sci Counc Repub China B 1994, 55, 533–540.KortingH.C.SchindlerS.HartingerA.KerscherM.AngerpointnerT.MaibachH.I.MTT-assay and neutral red release (NRR)-assay: relative role in the prediction of the irritancy potential of surfactants199455533–54010.1016/0024-3205(94)00746-2Search in Google Scholar
Korzeniewski C., Callewaert D.M.: An enzyme-release assay for natural cytotoxicity. J Immunol Methods 1983, 64, 313–320.KorzeniewskiC.CallewaertD.M.An enzyme-release assay for natural cytotoxicity198364313–32010.1016/0022-1759(83)90438-6Search in Google Scholar
Lasek W., Janyst M., Wolny R., Zapała Ł., Bocian K., Drela N.: Immuno-modulatory effects of inosine pranobex on cytokine production by human lymphocytes. Acta Pharm Jun 2015, 65, 171–180.LasekW.JanystM.WolnyR.Zapała ŁBocian K.DrelaN.Immuno-modulatory effects of inosine pranobex on cytokine production by human lymphocytes201565171–18010.1515/acph-2015-0015Search in Google Scholar
Lubet R.A., Kouri R.E., Curren R.A., Putman D.L., Schechtman L.M.: Induction of mutagenesis and transformation in BALB/c-3T3 clone A31-1 cells by diverse chemical carcinogens. Environ Mol Mutagen 1990, 16, 13–20.LubetR.A.KouriR.E.CurrenR.A.PutmanD.L.SchechtmanL.M.Induction of mutagenesis and transformation in BALB/c-3T3 clone A31-1 cells by diverse chemical carcinogens19901613–2010.1002/em.2850160103Search in Google Scholar
Majewska A., Lasek W., Janyst M., Młynarczyk G.: In vitro inhibition of HHV-1 replication by inosine pranobex and interferon- α. Acta Poloniae Pharmaceutica - Drug Res 2016, 73, 637–644.MajewskaA.LasekW.JanystM.MłynarczykG.In vitro inhibition of HHV-1 replication by inosine pranobex and interferon- α201673637–644Search in Google Scholar
Majewska A., Lasek W., Młynarczyk G.: Inosine pranobex - cytotoxic activities and effect of on replication of human para-influenza viruses (HPIV-2, HPIV-4), entroviruses (CA16, EV71) and adenoviruses (HAdV-2, HAdV-5) in vitro Med Dosw Mikrobiol 2015, 67, 107–113.MajewskaA.LasekW.MłynarczykG.Inosine pranobex - cytotoxic activities and effect of on replication of human para-influenza viruses (HPIV-2, HPIV-4), entroviruses (CA16, EV71) and adenoviruses (HAdV-2, HAdV-5) in vitro201567107–113Search in Google Scholar
Medicines & Healthcare products Regulatory Agency (MHRA), 2016. Patient leaflet: information for the user imunovir ® 500 mg tablets.Search in Google Scholar
http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1476421779978.pdf.Search in Google Scholar
Morin A., Ballet J.J.: A recent review on in vitro and in vivo immunological activities of methisoprinol. Allergol Immunopathol 1982, 10, 109–114.MorinA.BalletJ.J.A recent review on in vitro and in vivo immunological activities of methisoprinol198210109–114Search in Google Scholar
Mosmann T.: Rapid colourimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65, 55–63.MosmannT.Rapid colourimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays19836555–6310.1016/0022-1759(83)90303-4Search in Google Scholar
NIEHS (National Institute of Environmental Health Sciences), Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Co-ordinating Committee on the Validation of Alternative Methods. NIH Publication No. 97-3981. https://ntp.niehs.nih.gov/iccvam/docs/about_docs/validate.pdf.https://ntp.niehs.nih.gov/iccvam/docs/about_docs/validate.pdf.Search in Google Scholar
OECD, 2010. “Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systemic Toxicity Tests” OECD Guideline for the Testing of Chemicals, Guideline 129, 20 July 2010.OECD2010“Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systemic Toxicity Tests” OECD Guideline for the Testing of Chemicals12920July 2010Search in Google Scholar
Olivier P., Testard P., Marzin D., Abbott D.: Effect of high polyol concentrations on the neutral red absorption assay and tetrazolium-MTT test of rat hepatocytes in primary culture. Toxicol In Vitro 1995, 9, 133–138.OlivierP.TestardP.MarzinD.AbbottD.Effect of high polyol concentrations on the neutral red absorption assay and tetrazolium-MTT test of rat hepatocytes in primary culture19959133–13810.1016/0887-2333(94)00209-DSearch in Google Scholar
Petrova M., Jelev D., Ivanova A., Krastev Z.: Isoprinosine affects serum cytokine levels in healthy adults. J Interferon Cytokine Res 2010, 30, 223–228.PetrovaM.JelevD.IvanovaA.KrastevZ.Isoprinosine affects serum cytokine levels in healthy adults201030223–22810.1089/jir.2009.0057Search in Google Scholar
Scheers E.M., Ekwall B., Dierickx P.J.,: In vitro long–term cytotoxicity testing of 27 MEIC chemicals on HepG2 cells and 220 comparison with acute human toxicity data. Toxicol In Vitro 15, 2001, 153–161.ScheersE.M.EkwallB.DierickxP.J.In vitro long–term cytotoxicity testing of 27 MEIC chemicals on HepG2 cells and 220 comparison with acute human toxicity data152001153–16110.1016/S0887-2333(00)00062-XSearch in Google Scholar
Terpiłowska S., Siwicki A.K.: Interactions between chromium(III) and iron(III), molybdenum(III) or nickel(II): Cytotoxicity, genotoxicity and mutagenicity studies. Chemosphere 2018, doi: 10.1016/j.chemosphere.2018.03.062.TerpiłowskaS.SiwickiA.K.Interactions between chromium(III) and iron(III), molybdenum(III) or nickel(II): Cytotoxicity, genotoxicity and mutagenicity studies2018doi: 10.1016/j.chemosphere.2018.03.06210.1016/j.chemosphere.2018.03.062Search in Google Scholar
Triglia D., Braa S.S., Donnelly T., Kidd I.: A 3-dimensional human dermal model substrate for in vitro toxicological studies. In: Alternative Methods in Toxicology Edited by A.M. Goldberg, M.L. Principe. Mary Ann Liebert, New York, 1991, vol. 8, pp. 351–362.TrigliaD.BraaS.S.DonnellyT.KiddI.A 3-dimensional human dermal model substrate for in vitro toxicological studiesEdited by A.M. Goldberg, M.L. Principe. Mary Ann LiebertNew York1991vol. 8, pp351–362Search in Google Scholar
Triglia D., Sherard Braa S., Yonan C., Naughton G.K.: Cytotoxicity testing using neutral red and MTT assays on a three-dimensional human skin substrate. Toxicol In Vitro 1991, 5, 573–578.TrigliaD.SherardBraa S.YonanC.NaughtonG.K.Cytotoxicity testing using neutral red and MTT assays on a three-dimensional human skin substrate19915573–57810.1016/0887-2333(91)90096-VSearch in Google Scholar
van de Sandt J.J.M., Rutten A.A.J.J.L., Koeeter H.B.W.M.: Cutaneous toxicity testing in organ culture: neutral red uptake and reduction of tetrazolium salt (MTT). Toxicol In Vitro 1993, 7, 81–86.vande Sandt J.J.M.RuttenA.A.J.J.L.KoeeterH.B.W.M.Cutaneous toxicity testing in organ culture: neutral red uptake and reduction of tetrazolium salt (MTT)1993781–8610.1016/0887-2333(93)90115-LSearch in Google Scholar
Vian L., Vincent J., Maurin J., Fabre I., Giroux J., Cano J.P.: Comparison of three in vitro cytotoxicity assays for estimating surfactant ocular irritation. Toxicol In Vitro 1995, 9, 185–190.VianL.VincentJ.MaurinJ.FabreI.GirouxJ.CanoJ.P.Comparison of three in vitro cytotoxicity assays for estimating surfactant ocular irritation19959185–19010.1016/0887-2333(94)00200-ESearch in Google Scholar
Wybran J., Faman J.P., Gortz R.: Inosiplex (Isoprinosine): a review of its immunological and clinical effects in disease. Adv Pharmacol Ther 1982, 6, 123–131.WybranJ.FamanJ.P.GortzR.Inosiplex (Isoprinosine): a review of its immunological and clinical effects in disease19826123–131Search in Google Scholar