This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Ames B.N., McCann J., Yamasaki E.: Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res 1975, 31, 347–364.AmesB.N.McCannJ.YamasakiE.Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test197531347–36410.1016/0165-1161(75)90046-1Search in Google Scholar
Ballet J.J., Morin A., Schmitt C., Agrapart M.: Effect of isoprinosine on in vitro proliferative responses of human lymphocytes stimulated by antigen. Int J Immunopharmacol 1982, 4, 151–157.BalletJ.J.MorinA.SchmittC.AgrapartM.Effect of isoprinosine on in vitro proliferative responses of human lymphocytes stimulated by antigen19824151–15710.1016/0192-0561(82)90043-1Search in Google Scholar
Campoli-Richards D.M., Sorkin E.M., Heel R.C.: Inosine pranobex. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 1986, 32, 383–424.Campoli-RichardsD.M.SorkinE.M.HeelR.C.Inosine pranobex198632383–42410.2165/00003495-198632050-00001Search in Google Scholar
Fang J.L., Beland F.A.: Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci 2009, 111, 120–130.FangJ.L.BelandF.A.Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes2009111120–13010.1093/toxsci/kfp136Search in Google Scholar
Gutierrez J., Issacson R.S., Koppel B.S.: Subacute sclerosing panencephalitis: an update. Dev Med Child Neurol 2010, 52, 901–907.GutierrezJ.IssacsonR.S.KoppelB.S.Subacute sclerosing panencephalitis: an update201052901–90710.1111/j.1469-8749.2010.03717.xSearch in Google Scholar
Hennessy K.J., Blecha F., Pollmann D.S., Kluber E.F.: Isoprinosine and levamisole immunostimulation in artificially reared neonatal pigs. Am J Vet Res 1987, 48, 477–480.HennessyK.J.BlechaF.PollmannD.S.KluberE.F.Isoprinosine and levamisole immunostimulation in artificially reared neonatal pigs198748477–480Search in Google Scholar
OECD Guidelines for the Testing of Chemicals, Section 4, Test No. 471: Bacterial Reverse Mutation Test.Search in Google Scholar
OECD Guideline 487: In Vitro Mammalian Cell Micronucleus Test.Mammalian Cell Micronucleus TestSearch in Google Scholar
http://www.eurofins.com/biopharma-services/discovery/services/adme-tox/in-vitro-toxicity/genotoxicity/ames-test/.Search in Google Scholar
ICH guideline S2 (R1) on genotoxicity testing and data interpretation for pharmaceuticals intended for human use Step 5, EMA/CHMP/ICH/126642/200.Search in Google Scholar
Lasek W., Janyst M., Wolny R. Zapała Ł., Bocian K., Drela N.: Immuno-modulatory effects of inosine pranobex on cytokine production by human lymphocytes. Acta Pharm 2015, 65, 171–180.LasekW.JanystM.WolnyR. Zapała Ł.BocianK.DrelaN.Immuno-modulatory effects of inosine pranobex on cytokine production by human lymphocytes201565171–18010.1515/acph-2015-0015Search in Google Scholar
Majewska A., Lasek W., Młynarczyk G.: Inosine pranobex - cytotoxic activities and effect of on replication of human parainfluenza viruses (HPIV-2, HPIV-4), enteroviruses (CA16, EV71), and adenoviruses (HAdV-2, HAdV-5) in vitro Med Dosw Mikrobiol 2015, 67, 107–113.MajewskaA.LasekW.MłynarczykG.Inosine pranobex - cytotoxic activities and effect of on replication of human parainfluenza viruses (HPIV-2, HPIV-4), enteroviruses (CA16, EV71), and adenoviruses (HAdV-2, HAdV-5) in vitro201567107–113Search in Google Scholar
Maron D.M., Ames B.N.: Revised methods for the Salmonella mutagenicity test. Mutat Res 1983, 113, 173–215.MaronD.M.AmesB.N.Revised methods for the Salmonella mutagenicity test1983113173–21510.1016/B978-0-444-80519-5.50011-0Search in Google Scholar
Meek B., Doull J.: Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: another Ames test? ...or a new edition of “the Red Book”? Toxicol Sci 2009, 108, 19–21.MeekB.DoullJ.Pragmatic challenges for the vision of toxicity testing in the 21st century in a regulatory context: another Ames test?200910819–2110.1093/toxsci/kfp008Search in Google Scholar
Nakamura T., Miyasaka N., Pope R.M., Talal N., Russell I.J.: Immunomodulation by isoprinosine: effects on in vitro immune functions of lymphocytes from humans with autoimmune diseases. Clin Exp Immunol 1983, 52, 67–74.NakamuraT.MiyasakaN.PopeR.M.TalalN.RussellI.J.Immunomodulation by isoprinosine: effects on in vitro immune functions of lymphocytes from humans with autoimmune diseases19835267–74Search in Google Scholar
Ohnishi H., Kosuzume H., Inaba H., Okura M., Morita Y., Mochizuki H., Suzuki Y.: Mechanism of host defence suppression induced by viral infection: mode of action of inosiplex as an antiviral agent. Infect Immun 1982, 38, 243–250.OhnishiH.KosuzumeH.InabaH.OkuraM.MoritaY.MochizukiH.SuzukiY.Mechanism of host defence suppression induced by viral infection: mode of action of inosiplex as an antiviral agent198238243–25010.1128/iai.38.1.243-250.1982Search in Google Scholar
Ohnishi H., Kosuzume H., Inaba H., Ohkura M., Shimada S., Suzuki Y.: The immunomodulatory action of inosiplex in relation to its effects in experimental viral infections. Int J Immunopharmacol 1983, 5, 181–196.OhnishiH.KosuzumeH.InabaH.OhkuraM.ShimadaS.SuzukiY.The immunomodulatory action of inosiplex in relation to its effects in experimental viral infections19835181–19610.1016/0192-0561(83)90055-3Search in Google Scholar
Osidak L.V., Obraztsova E.V.: The results of studying of inclusion of inosine pranobex into the therapy of acute respiratory viral infections in children (in Russian). Lechaschiy Vrach 2012, 10, 1–4.OsidakL.V.ObraztsovaE.V.The results of studying of inclusion of inosine pranobex into the therapy of acute respiratory viral infections in children (in Russian)2012101–4Search in Google Scholar
Pedersen C., Sandström E., Petersen C.S., Norkrans G., Gersto J., Karlsson A., Christensen K.C., Håkanson C., Pehrson P., Nielsen J.O., Jucrgensen H.J.: Scandinavian Isoprinosine Study Group: The efficacy of inosine pranobex in preventing the acquired immunodeficiency syndrome in patients with human immunodeficiency virus infection. N Engl J Med 1990, 322, 1757–1763.PedersenC.SandströmE.PetersenC.S.NorkransG.GerstoJ.KarlssonA.ChristensenK.C.HåkansonC.PehrsonP.NielsenJ.O.JucrgensenH.J.Scandinavian Isoprinosine Study Group: The efficacy of inosine pranobex in preventing the acquired immunodeficiency syndrome in patients with human immunodeficiency virus infection19903221757–176310.1056/NEJM199006213222501Search in Google Scholar
Petrova M., Jelev D., Ivanova A., Krastev Z.: Isoprinosine affects serum cytokine levels in healthy adults. J Interferon Cytokine Res 2010, 30, 223–228.PetrovaM.JelevD.IvanovaA.KrastevZ.Isoprinosine affects serum cytokine levels in healthy adults201030223–22810.1089/jir.2009.0057Search in Google Scholar
Roe A.L., Snawder J.E., Benson R.W., Roberts D.W., Casciano D.A.: HepG2cells: an in vitro model for P450-dependent metabolism of acetaminophen. Biochem Biophys Res Commun 1993, 190, 15–19.RoeA.L.SnawderJ.E.BensonR.W.RobertsD.W.CascianoD.A.HepG2cells: an in vitro model for P450-dependent metabolism of acetaminophen199319015–1910.1006/bbrc.1993.1003Search in Google Scholar
Schoonen W.G., de Roos J.A., Westerink W.M., Débiton E.: Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells. II mechanistic assays on NAD(P)H, ATP and DNA contents. Toxicol in Vitro 2005, 19, 491–503.SchoonenW.G.deRoos J.A.WesterinkW.M.DébitonE.Cytotoxic effects of 110 reference compounds on HepG2 cells and for 60 compounds on HeLa, ECC-1 and CHO cells200519491–50310.1016/j.tiv.2005.01.002Search in Google Scholar
Simon L.N., Glasky A.J.: Isoprinosine: an overview. Cancer Treat Rep 1978, 62, 1963–1969.SimonL.N.GlaskyA.J.Isoprinosine: an overview1978621963–1969Search in Google Scholar
Terpilowska S., Siwicki A.K.: Interactions between chromium(III) and iron(III), molybdenum(III) or nickel(II): Cytotoxicity, genotoxicity, and mutagenicity studies. Chemosphere 2018, 201, 780–789.TerpilowskaS.SiwickiA.K.Interactions between chromium(III) and iron(III), molybdenum(III) or nickel(II): Cytotoxicity, genotoxicity, and mutagenicity studies2018201780–78910.1016/j.chemosphere.2018.03.062Search in Google Scholar
Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.C., Sasaki Y.F.: Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 2000, 35, 206–221.TiceR.R.AgurellE.AndersonD.BurlinsonB.HartmannA.KobayashiH.MiyamaeY.RojasE.RyuJ.C.SasakiY.F.Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing200035206–22110.1002/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-JSearch in Google Scholar
Tsang H., Fudenberg H., Gnagy M.J.: Restoration of immune response of aging hamsters by treatment with Isoprinosine. J Clin Invest 1983, 71, 1750–1755.TsangH.FudenbergH.GnagyM.J.Restoration of immune response of aging hamsters by treatment with Isoprinosine1983711750–175510.1172/JCI110930Search in Google Scholar
Wybran J., Faman J.P., Gortz R.: Inosiplex (Isoprinosine): a review of its immunological and clinical effects in disease. Adv Pharmacol Ther 1982, 6, 123–131.WybranJ.FamanJ.P.GortzR.Inosiplex (Isoprinosine): a review of its immunological and clinical effects in disease19826123–131Search in Google Scholar
Wybran J., Govaerts A., Appleboom, T.: Inosiplex, a stimulating agent for normal human T cells and human leukocytes. J Immunol 1978, 121, 1184–1187.WybranJ.GovaertsA.AppleboomT.Inosiplex, a stimulating agent for normal human T cells and human leukocytes19781211184–118710.4049/jimmunol.121.3.1184Search in Google Scholar
Yakupova R.S., Skachkova M.A., Choloyan S.B., Karpova E.G.: Efficacy of immunomodulators in children with respiratory diseases in environmentally poor areas. Gig Sanit 2012, 3, 33–34.YakupovaR.S.SkachkovaM.A.CholoyanS.B.KarpovaE.G.Efficacy of immunomodulators in children with respiratory diseases in environmentally poor areas2012333–34Search in Google Scholar