Concentration of inosine | Percentage tail DNA | |
---|---|---|
pranobex (μg/mL) | BALB/ 3T3 clone A31 cells | HepG2 cells |
0 | 1 | 1 |
0.1 | 1 | 1 |
0.5 | 1 | 2 |
1 | 1 | 1 |
5 | 1 | 1 |
10 | 2 ± 0.1 | 1 |
50 | 2 ± 0.1 | 2 ± 0.1 |
100 | 2 ± 0.1 | 3 ± 0.1 |
500 | 3 ± 0.2 | 2 ± 0.1 |
1,000 | 4 ± 0.2* | 5 ± 0.3* |
Concentration of Inosine | BNMN‰ | |
---|---|---|
pranobex (μg/mL) | BALB/3T3 clone A31 cells | HepG2 cells |
0 | 0 | 1 |
0.1 | 1 | 0 |
0.5 | 2 ± 0.1 | 3 ± 0.1 |
1 | 2 ± 0.1 | 2 ± 0.1 |
5 | 2 ± 0.1 | 4 ± 0.2 |
10 | 3 ± 0.2 | 3 ± 0.2 |
50 | 4 ± 0.2 | 2 ± 0.1 |
100 | 4 ± 0.3 | 4 ± 0.2 |
500 | 5 ± 0.3 | 6 ± 0.3 |
1,000 | 6 ± 0.4* | 10 ± 0.9* |
Strain | Substance |
---|---|
TA97a | 9AA (9- aminoacridine) |
TA98 | 2-NF (2-nitrofluorene) |
TA100 | NaN3 (sodium azide) |
TA102 | Cumene hydroperoxide |
TA1535 | NaN3 (sodium azide) |
Concentration of inosine pranobex ( μg/mL) | TA97a | TA98 | TA100 | TA102 | TA1535 | |||||
---|---|---|---|---|---|---|---|---|---|---|
-S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | |
0.1 | 4 ± 0.1 | 9 ± 0.7* | 6 ± 0.1* | 7 ± 0.3* | 12 ± 1* | 15 ± 1* | 11 ± 1* | 11 ± 1* | 10 ± 0.7* | 11 ± 1* |
0.5 | 2 ± 0.1 | 5 ± 0.3 | 2 ± 0.1 | 3 ± 0.1 | 12 ± 1* | 12 ± 1* | 12 ± 1* | 12 ± 1* | 12 ± 1* | 12 ± 1* |
1 | 3 ± 0.2 | 4 ± 0.1 | 4 ± 0.2 | 6 ± 0.3* | 2 ± 0.1 | 5 ± 0.1* | 3 ± 0.1 | 3 ± 0.1 | 3 ± 0.1 | 6 ± 0.2* |
5 | 5 ± 0.3 | 7 ± 0.3* | 9 ± 0.5* | 9 ± 0.4* | 4 ± 0.1 | 6 ± 0.12* | 4 ± 0.1 | 4 ± 0.1 | 4 ± 0.1 | 4 ± 0.1 |
10 | 6 ± 0.4 | 6 ± 0.3 | 6 ± 0.3* | 7 ± 0.3* | 8 ± 0.5* | 9 ± 0.3* | 8 ± 0.4* | 9 ± 0.5* | 8 ± 0.5* | 9 ± 0.4* |
50 | 5 ± 0.3 | 8 ± 0.5* | 6 ± 0.4* | 7 ± 0.2* | 11 ± 1* | 11 ± 1* | 9 ± 0.6* | 9 ± 0.4* | 11 ± 0.9* | 12 ± 1* |
100 | 6 ± 0.4 | 6 ± 0.3 | 7 ± 0.3* | 7 ± 0.3* | 7 ± 0.4* | 7 ± 0.4* | 9 ± 0.7* | 9 ± 0.5* | 9 ± 0.5* | 9 ± 0.6* |
500 | 9 ± 0.6 | 9 ± 0.4* | 11 ± 0.8* | 11 ± 0.8* | 11 ± 1* | 11 ± 1* | 10 ± 1* | 10 ± 0.6* | 9 ± 0.6* | 10 ± 0.8* |
1,000 | 8 ± 0.7* | 8 ± 0.5* | 5 ± 0.2* | 7 ± 0.4* | 9 ± 0.5* | 9 ± 0.3* | 9 ± 0.4* | 9 ± 0.5* | 9 ± 0.7* | 9 ± 0.6* |
9AA | 43 | 43 | ||||||||
2-NF | 69 | 69 | ||||||||
NaN3 | 85 | 85 | ||||||||
Cumene | 84 | 84 | ||||||||
hydroperoxide | ||||||||||
NaN3 | 85 | 85 |