<abstract xmlns="http://www.w3.org/1999/xhtml"><p>We studied the simultaneous influence of histamine and sodium hypochlorite (SH) on lipid peroxidation processes, as well as the level of structural changes in membranes (via the content of sialic acid) in rat erythrocytes. We established that histamine affects lipid peroxidation processes with the formation of lipid hydroperoxides, damages proteins and reduces the content of sialic acids, which leads to changes in the surface charge of red blood cells. However, the simultaneous action of histamine and low SH concentration has a positive effect in that it corrects the pro-oxidant state of erythrocytes. Hence, the content of lipid hydroperoxides, TBA-active products, carbonyl groups of proteins and sialic acids were mainly reduced after the simultaneous action of histamine and SH at all studied concentrations during the rehabilitation period.</p></abstract>

We studied the simultaneous influence of histamine and sodium hypochlorite (SH) on lipid peroxidation processes, as well as the level of structural changes in membranes (via the content of sialic acid) in rat erythrocytes. We established that histamine affects lipid peroxidation processes with the formation of lipid hydroperoxides, damages proteins and reduces the content of sialic acids, which leads to changes in the surface charge of red blood cells. However, the simultaneous action of histamine and low SH concentration has a positive effect in that it corrects the pro-oxidant state of erythrocytes. Hence, the content of lipid hydroperoxides, TBA-active products, carbonyl groups of proteins and sialic acids were mainly reduced after the simultaneous action of histamine and SH at all studied concentrations during the rehabilitation period.

Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes

Current Issues in Pharmacy and Medical Sciences

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

We studied the simultaneous influence of histamine and sodium hypochlorite (SH) on lipid peroxidation processes, as well as the level of structural changes in...

Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes

Publié en ligne: 13 sept. 2020

Pages: 125 - 131

Reçu: 18 déc. 2019

Accepté: 20 avr. 2020

DOI: https://doi.org/10.2478/cipms-2020-0023

Mots clés
histamine, sodium hypochlorite, erythrocytes, lipid peroxidation – LP, sodium hypochlorite – SH, thiobarbituric acid – TBA

© 2020 Nataliya Harasym et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes

Publié en ligne: 13 sept. 2020

Pages: 125 - 131

Reçu: 18 déc. 2019

Accepté: 20 avr. 2020

DOI: https://doi.org/10.2478/cipms-2020-0023

Mots cléshistamine, sodium hypochlorite, erythrocytes, lipid peroxidation – LP, sodium hypochlorite – SH, thiobarbituric acid – TBA

© 2020 Nataliya Harasym et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
histamine, sodium hypochlorite, erythrocytes, lipid peroxidation – LP, sodium hypochlorite – SH, thiobarbituric acid – TBA