<abstract xmlns="http://www.w3.org/1999/xhtml"><p>We studied the simultaneous influence of histamine and sodium hypochlorite (SH) on lipid peroxidation processes, as well as the level of structural changes in membranes (via the content of sialic acid) in rat erythrocytes. We established that histamine affects lipid peroxidation processes with the formation of lipid hydroperoxides, damages proteins and reduces the content of sialic acids, which leads to changes in the surface charge of red blood cells. However, the simultaneous action of histamine and low SH concentration has a positive effect in that it corrects the pro-oxidant state of erythrocytes. Hence, the content of lipid hydroperoxides, TBA-active products, carbonyl groups of proteins and sialic acids were mainly reduced after the simultaneous action of histamine and SH at all studied concentrations during the rehabilitation period.</p></abstract>

We studied the simultaneous influence of histamine and sodium hypochlorite (SH) on lipid peroxidation processes, as well as the level of structural changes in membranes (via the content of sialic acid) in rat erythrocytes. We established that histamine affects lipid peroxidation processes with the formation of lipid hydroperoxides, damages proteins and reduces the content of sialic acids, which leads to changes in the surface charge of red blood cells. However, the simultaneous action of histamine and low SH concentration has a positive effect in that it corrects the pro-oxidant state of erythrocytes. Hence, the content of lipid hydroperoxides, TBA-active products, carbonyl groups of proteins and sialic acids were mainly reduced after the simultaneous action of histamine and SH at all studied concentrations during the rehabilitation period.

Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes

Current Issues in Pharmacy and Medical Sciences

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We studied the simultaneous influence of histamine and sodium hypochlorite (SH) on lipid peroxidation processes, as well as the level of structural changes in...

Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes

Published Online: Sep 13, 2020

Page range: 125 - 131

Received: Dec 18, 2019

Accepted: Apr 20, 2020

DOI: https://doi.org/10.2478/cipms-2020-0023

Keywords
histamine, sodium hypochlorite, erythrocytes, lipid peroxidation – LP, sodium hypochlorite – SH, thiobarbituric acid – TBA

© 2020 Nataliya Harasym et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Effects of histamine and sodium hypochlorite on prooxidand state in the rats erytrocytes

Published Online: Sep 13, 2020

Page range: 125 - 131

Received: Dec 18, 2019

Accepted: Apr 20, 2020

DOI: https://doi.org/10.2478/cipms-2020-0023

Keywordshistamine, sodium hypochlorite, erythrocytes, lipid peroxidation – LP, sodium hypochlorite – SH, thiobarbituric acid – TBA

© 2020 Nataliya Harasym et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
histamine, sodium hypochlorite, erythrocytes, lipid peroxidation – LP, sodium hypochlorite – SH, thiobarbituric acid – TBA