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Relationship between chromosomal aberrations and gene expressions in the p53 pathway in chronic lymphocytic leukemia

G Öztan

G Öztan

Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul Universityİstanbul, Turkey
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Öztan, G
, 
M Aktan

M Aktan

Department of Internal Medicine, Division of Hematology, İstanbul University Faculty of Medicineİstanbul, Turkey
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Aktan, M
, 
S Palanduz

S Palanduz

Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul Universityİstanbul, Turkey
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Palanduz, S
, 
H İşsever

H İşsever

Department of Public Health, İstanbul University Faculty of Medicineİstanbul, Turkey
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İşsever, H
, 
S Öztürk

S Öztürk

Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul Universityİstanbul, Turkey
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Öztürk, S
, 
E Nikerel

E Nikerel

Department of Genetics and Bioengineering, Yeditepe Universityİstanbul, Turkey
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Nikerel, E
, 
A Uçur

A Uçur

Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul Universityİstanbul, Turkey
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Uçur, A
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G Bağatir

G Bağatir

Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul Universityİstanbul, Turkey
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Bağatir, G
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A Bayrak

A Bayrak

Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul Universityİstanbul, Turkey
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Bayrak, A
 et 
K Çefle

K Çefle

Division of Medical Genetics, Istanbul Faculty of Medicine, Istanbul Universityİstanbul, Turkey
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Çefle, K
  
26 août 2020
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Catégorie d'article: Original Article
Publié en ligne: 26 août 2020
Pages: 15 - 24
DOI: https://doi.org/10.2478/bjmg-2020-0007
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© 2020 Öztan G, Aktan M, Palanduz S, İşsever H, Öztürk S, Nikerel E, Uçur A, Bağatir G, Bayrak B, Çefle K, published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Scatterplot comparing the normalized expression of genes between the CLL patients and healthy controls. Genes involved in CLL cell cycle and cell growth, proliferation and differentiation and apoptosis are shown. The central line indicates unchanged gene expression. Red dots represent genes with a fold regulation of >2.
Scatterplot comparing the normalized expression of genes between the CLL patients and healthy controls. Genes involved in CLL cell cycle and cell growth, proliferation and differentiation and apoptosis are shown. The central line indicates unchanged gene expression. Red dots represent genes with a fold regulation of >2.

Figure 2

Illustration of interactions between the 18 differentially-expressed genes in CLL patients (String v10, confidence view).
Illustration of interactions between the 18 differentially-expressed genes in CLL patients (String v10, confidence view).

The mean difference values of the patient and control group according to average ᐃCt and fold change_

GeneAverage CtAverage ᐃCt2-ᐃCtFold Changep ValueFold Regulation
CLLControlCLLControlCLLControlCLL/ Control95% CICLL/ Control
APAF126.5725.287.727.540.0046950.0053680.870.78-0.960.072729-1.14
ATM27.8527.919.0110.170.0019360.0008692.231.67-2.79<0.0012.23
ATR29.0029.4110.1711.670.0008710.0003072.832.23-3.43<0.0012.83
BAX25.6125.876.788.130.0091160.0035782.552.15-2.95<0.0012.55
CASP927.3527.588.529.840.0027230.0010912.502.06-2.94<0.0012.50
CDK426.9227.968.0910.220.0036720.0008394.383.20-5.56<0.0014.38
CDKN1A27.5926.828.759.080.0023150.0018521.250.97-1.530.0661.25
CDKN2A30.5032.7711.6715.020.0003070.00003010.227.14-13.3<0.00110.22
CHEK131.3731.5812.5413.830.0001680.0000682.451.98-2.92<0.0012.45
CHEK229.4530.4210.6212.680.0006380.0001524.183.02-5.34<0.0014.18
E2F131.4430.8812.6013.140.0001610.0001111.451.04-1.860.0127411.45
E2F328.8827.0910.059.340.0009440.0015410.610.53-0.69<0.001-1.63
GADD45A31.9431.1413.1013.390.0001140.0000931.220.90-1.540.1211.22
MCL123.3421.854.514.110.0439500.0579650.760.66-0.86<0.001-1.32
MDM225.7725.606.937.860.0081840.0043121.901.56-2.24<0.0011.90
MDM427.4328.008.6010.260.0025770.0008183.152.32-3.998<0.0013.15
PCNA25.7526.366.928.620.0082660.0025453.252.64-3.86<0.0013.25
PTEN25.5324.056.506.310.0110360.0126150.870.78-0.960.062542-1.14
RB126.5127.047.679.290.0048940.0015953.072.40-3.74<0.0013.07
P5325.7626.326.928.580.0082290.0026193.142.47-3.81<0.0013.14
PTX332.5030.5313.6712.790.0000770.0001410.540.37-0.710.006057-1.84
BCL225.9427.947.1110.200.0072310.0008508.5'5.46-11.56<0.0018.51

Patient diagnostic data and FISH results_

nSex-AgePrognosisRai StageBinet StageFISH Results(WBC 109/L)Hb (g/dL)Platelet (109/L)
del(13q)del(17p)+12Normal

Non-del(13q), del(17p), +12.

1F-75bad1B[–][+][–][–]12.612.7166.0
2M-71good0A[–][–][–][+]23.012.0203.0
3M-57good0A[–][–][–][+]24.815.1262.0
4M-56good3A[–][–][–][+]71.413.249.0
5F-59bad2B[–][+][–][–]7.910.9284.0
6F-74bad2B[–][+][–][–]108.610.3190.0
7F-63bad2A[–][+][–][–]35.413.4185.0
8M-80bad2A[–][+][–][–]3.612.9104.0
9F-62bad0A[–][–][+][–]190.212.0192.0
10M-67bad2A[–][–][+][–]142.611.681.0
11F-65bad0A[–][–][+][–]5.212.1144.0
12F-74bad2A[–][–][+][–]179.711.9321.0
13F-86bad3A[–][–][+][–]213.08.6113.0
14M-60good3A[–][–][–][+]51.79.4137.0
15M-46good2A[–][–][–][+]15.014.4184.0
16M-54good0A[–][–][–][+]41.913.8352.0
17F-61good1A[–][–][–][+]11.812.1148.0
18F-67good0A[–][–][–][+]195.310.8188.0
19F-53good2B[–][–][–][+]39.811.4135.0
20M-67good0A[+][–][–][–]74.612.4183.0
21M-62good2A[+][–][–][–]121.414.5294.0
22M-68good0A[+][–][–][–]37.713.9197.0
23F-46good1A[+][–][–][–]59.412.391.0
24M-58good2B[+][–][–][–]201.411.1101.0
25M-66good0A[+][–][–][–]43.912.388.0
26M-61good4C[+][–][–][–]110.013.939.0
27M-51good2A[+][–][–][–]98.514.3250.0
28F-78good3B[+][–][–][–]13.711.0324.0
29F-63good0A[+][–][–][–]113.311.5178.0
30M-64good0A[+][–][–][–]432.015.3206.0
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