<abstract xmlns="http://www.w3.org/1999/xhtml">

<p>This <italic>in silico</italic> study has been designed to validate ethnomedicinal properties of some Himalayan fermented ethnic beverages against varied high-altitude sicknesses. Traditional beverages like <italic>tongba</italic>, <italic>chhyang</italic>, <italic>nigar</italic> and finger-millet <italic>raksi</italic> (supplemented with ethnomedicines like <italic>khokim</italic> and <italic>chimphing</italic>) were considered in this study which were sampled from villages situated in Singalila Ridge of the Himalayas. Seven major metabolites such as ethyl alpha-D-glucopyranoside; meranzin; auraptene; cis-vaccenic acid; cyclo(pro-gly); cyclo(leu-pro); and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one were investigated <italic>in silico</italic> to provide insights to their efficiency in alleviating major altitude illnesses (pulmonary edema and hypoxia); high-altitude respiratory infections; pain or inflammation; cardiovascular problems; gastrointestinal diseases and disorders; and high-altitude neurological diseases and disorders. Computational tools such as Molinspiration Chemoinformatics, SwissADME, Molsoft program and vNN-ADMET were employed to evaluate physicochemical properties, pharmacokinetics and ADMET parameters. Binding affinities were computed using Auto Dock Tools. <italic>In silico</italic> pharmacokinetics and ADMET revealed bioactivity potentials of selected metabolites which are associated to treat high-altitude sickness. A total of 175 combinations of receptor-ligand docking interactions were considered out of which 141 combinations exhibited a binding energy score of ≤ -5 and 29 combinations scored ≤ -7. Outcome of this computational research affirm the effectiveness of high-altitude’s traditional drinks in healing high-altitudinal stresses.</p>
</abstract>

This in silico study has been designed to validate ethnomedicinal properties of some Himalayan fermented ethnic beverages against varied high-altitude sicknesses. Traditional beverages like tongba, chhyang, nigar and finger-millet raksi (supplemented with ethnomedicines like khokim and chimphing) were considered in this study which were sampled from villages situated in Singalila Ridge of the Himalayas. Seven major metabolites such as ethyl alpha-D-glucopyranoside; meranzin; auraptene; cis-vaccenic acid; cyclo(pro-gly); cyclo(leu-pro); and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one were investigated in silico to provide insights to their efficiency in alleviating major altitude illnesses (pulmonary edema and hypoxia); high-altitude respiratory infections; pain or inflammation; cardiovascular problems; gastrointestinal diseases and disorders; and high-altitude neurological diseases and disorders. Computational tools such as Molinspiration Chemoinformatics, SwissADME, Molsoft program and vNN-ADMET were employed to evaluate physicochemical properties, pharmacokinetics and ADMET parameters. Binding affinities were computed using Auto Dock Tools. In silico pharmacokinetics and ADMET revealed bioactivity potentials of selected metabolites which are associated to treat high-altitude sickness. A total of 175 combinations of receptor-ligand docking interactions were considered out of which 141 combinations exhibited a binding energy score of ≤ -5 and 29 combinations scored ≤ -7. Outcome of this computational research affirm the effectiveness of high-altitude’s traditional drinks in healing high-altitudinal stresses.

<italic>In Silico</italic> Insights into the Efficacy of Darjeeling Himalaya’s Traditional Fermented Beverages To Combat Various High-Altitude Sicknesses

Molecular Biology and Tissue Culture Laboratory

Acta Universitatis Cibiniensis. Series E: Food Technology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 Insights into the Efficacy of Darjeeling Himalaya’s Traditional Fermented Beverages To Combat Various High-Altitude Sicknesses

This in silico study has been designed to validate ethnomedicinal properties of some Himalayan fermented ethnic beverages against varied high-altitude...

In Silico Insights into the Efficacy of Darjeeling Himalaya’s Traditional Fermented Beverages To Combat Various High-Altitude Sicknesses

Publié en ligne: 11 janv. 2024

Pages: 261 - 292

Reçu: 06 nov. 2023

Accepté: 04 déc. 2023

DOI: https://doi.org/10.2478/aucft-2023-0022

Mots clés
Ethnic beverages, molecular docking, ADMET, high-altitude sickness

© 2023 Soumya Majumder et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

In Silico Insights into the Efficacy of Darjeeling Himalaya’s Traditional Fermented Beverages To Combat Various High-Altitude Sicknesses

Publié en ligne: 11 janv. 2024

Pages: 261 - 292

Reçu: 06 nov. 2023

Accepté: 04 déc. 2023

DOI: https://doi.org/10.2478/aucft-2023-0022

Mots clésEthnic beverages, molecular docking, ADMET, high-altitude sickness

© 2023 Soumya Majumder et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
Ethnic beverages, molecular docking, ADMET, high-altitude sickness