[Adewoyin, A.S., 2015. Management of sickle cell disease: a review for physician education in Nigeria (sub-saharan Africa). Anemia 2015, 791498. https://doi.org/10.1155/2015/79149810.1155/2015/791498]Search in Google Scholar
[Adewoyin, A.S., Alagbe, A.E., Adedokun, B.O., Idubor, N.T., 2015. Knowledge, attitude and control practices of sickle cell disease among youth corps members in Benin city, Nigeria. Ann. Ibadan Postgrad. Med. 13, 100–7.]Search in Google Scholar
[Adewoyin, A.S., Oghuvwu, O.S., Awodu, O.A., 2017. Hydroxyurea therapy in adult Nigerian sickle cell disease: a monocentric survey on pattern of use, clinical effects and patient’s compliance. Afr. Health Sci. 17, 255–261. https://doi.org/10.4314/ahs.v17i1.3110.4314/ahs.v17i1.31]Open DOISearch in Google Scholar
[Askari, G., Ghiasvand, R., Feizi, A., Ghanadian, S.M., Karimian, J., 2012. The effect of quercetin supplementation on selected markers of inflammation and oxidative stress. J. Res. Med. Sci. 17, 637–41. https://doi.org/10.1016/j.anbehav.2003.08.02710.1016/j.anbehav.2003.08.027]Open DOISearch in Google Scholar
[Babangida, S., Ibrahim, S., Muhammad, A., Arthur, D.E., Uzairu, A., Garba, A., 2018. The role of molecular modelling strategies in validating the effects of chrysin on sodium arsenite-induced chromosomal and DNA damage. Hum. Exp. Toxicol. 1–11. https://doi.org/10.1177/096032711775123310.1177/0960327117751233]Open DOISearch in Google Scholar
[Brandow, A.M., Panepinto, J.A., 2010. Hydroxyurea use in sickle cell disease: the battle with low prescription rates, poor patient compliance and fears of toxicities. Expert Rev. Hematol. 3, 255–60. https://doi.org/10.1586/ehm.10.2210.1586/ehm.10.22]Open DOISearch in Google Scholar
[Cesquini, M., Torsoni, M.A., Stoppa, G.R., Ogo, S.H., 2003. t-BOOHinduced oxidative damage in sickle red blood cells and the role of flavonoids. Biomed. Pharmacother. 57, 124–9.10.1016/S0753-3322(03)00018-0]Open DOISearch in Google Scholar
[Chance, B., Maehly, A.C., 1955. Assays of catalases and peroxidases. Meth Enzym. https://doi.org/http://dx.doi.org.ez66.periodicos.capes.gov.br/10.1016/S0076-6879(55)02300-810.1016/S0076-6879(55)02300-8]Open DOISearch in Google Scholar
[Chowdhury, P., Soulsby, M., 2002. Lipid peroxidation in rat brain is increased by simulated weightlessness and decreased by a soy-protein diet. Ann. Clin. Lab. Sci. https://doi.org/10.1016/j.pt.2006.02.00910.1016/j.pt.2006.02.00916503418]Open DOISearch in Google Scholar
[Damanhouri GA, Jarullah J, M.S., 2015. Clinical biomarkers in sickle cell disease. Saudi J. Biol. Sci. 22, 24–31.10.1016/j.sjbs.2014.09.005428163625561879]Search in Google Scholar
[Egert, S., Wolffram, S., Bosy-Westphal, A., Boesch-Saadatmandi, C., Wagner, A.E., Frank, J., Rimbach, G., Mueller, M.J., 2008. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J. Nutr. 138, 1615–1621. https://doi.org/138/9/1615 [pii]10.1093/jn/138.9.161518716159]Search in Google Scholar
[Egunyomi, A., Moody, J.O., Eletu, O.M., 2009. Antisickling activities of two ethnomedicinal plant recipes used for the management of sickle cell anaemia in Ibadan, Nigeria. African J. Biotechnol. 8, 20–25.]Search in Google Scholar
[Ellman, G.L., 1959. Tissue sulfhydryl groups. Arch. Biochem. Biophys. https://doi.org/10.1016/0003-9861(59)90090-610.1016/0003-9861(59)90090-6]Open DOISearch in Google Scholar
[Erukainure, O., Ajiboye, J., Abbah, U., Asieba, G., Mamuru, S., Zaruwa, M.Z., Manhas, N., Singh, P., Islam, M.S., 2017. Monodora myristica ( African nutmeg ) modulates redox homeostasis and alters functional chemistry in sickled erythrocytes. Hum. Exp. Toxicol. 37, 458–467. https://doi.org/10.1177/096032711771238510.1177/096032711771238528565971]Open DOISearch in Google Scholar
[Gibellini, L., Pinti, M., Nasi, M., Montagna, J.P., Biasi, S. De, Roat, E., Bertoncelli, L., Cooper, E.L., Cossarizza, A., 2011. Quercetin and Cancer Chemoprevention. Evidence-based Complement. Altern. Med. 2011, 15. https://doi.org/10.1093/ecam/neq05310.1093/ecam/neq053313671121792362]Open DOISearch in Google Scholar
[Kakkar, P., Das, B., Viswanathan, P.N., 1984. A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys. https://doi.org/10.1097/YCO.0b013e328011773310.1097/YCO.0b013e328011773317143074]Open DOISearch in Google Scholar
[Kiser, Z.M., McGee, M.D.M., Wright, R.J., Quarshie, A., Newman, G.W., Randall, K.R., Stiles, J.K., Driss, A., Hibbert, J.M., 2017. Quercetin reduces hydroxyurea induced cytotoxicity in immortalized mouse aortic endothelial cells. PeerJ 31, e3376. https://doi.org/10.7717/peerj.337610.7717/peerj.3376545533628584711]Open DOISearch in Google Scholar
[Kraus, A., Roth, H.P., Kirchgessner, M., 1997. Influence of vitamin C, vitamin E and beta-carotene on the osmotic fragility and the primary antioxidant system of erythrocytes in zinc-deficient rats. Arch. Tierernahr. 50, 257–269.927222310.1080/174503997093861379272223]Search in Google Scholar
[Macharia, A.W., Mochamah, G., Uyoga, S., Ndila, C.M., Nyutu, G., Makale, J., Tendwa, M., Nyatichi, E., Ojal, J., Shebe, M., Awuondo, K.O., Mturi, N., Peshu, N., Tsofa, B., Scott, J.A.G., Maitland, K., Williams, T.N., 2018. The clinical epidemiology of sickle cell anemia In Africa. Am. J. Hematol. 93, 363–370. https://doi.org/10.1002/ajh.2498610.1002/ajh.24986617537729168218]Open DOISearch in Google Scholar
[Mohanty, J.G., Nagababu, E., Rifkind, J.M., 2014. Red blood cell oxidative stress impairs oxygen delivery and induces red blood cell aging. Front. Physiol. 5, 84. https://doi.org/10.3389/fphys.2014.0008410.3389/fphys.2014.00084393798224616707]Open DOISearch in Google Scholar
[Muhammad, A., Arthur, D.E., Babangida, S., Erukainure, O.L., Malami, I., Sani, H., Abdulhamid, A.W., Ajiboye, I.O., Saka, A.A., Hamza, N.M., Asema, S., Ado, Z.M., Musa, T.I., 2018. Modulatory role of rutin on 2,5-hexanedione-induced chromosomal and DNA damage in rats: validation of computational predictions. Drug Chem. Toxicol. 10, 1–14. https://doi.org/doi:10.1080/01480545.2018.146594810.1080/01480545.2018.146594829745774]Open DOISearch in Google Scholar
[Muhammad, A., Ibrahim, M.A., Erukainure, O.L., Habila, N., Idowu, A.A., Ndidi, U.S., Malami, I., Zailani, H., Kudan, Z.B., Muhammad, B.A., 2016. Induction of Haemolysis and DNA Fragmentation in a Normal and Malarial-Infected Blood by Commonly - used Antimalarial Drugs in the North-Western Region of Nigeria. Drug Metab. Lett. 10, 49–55.10.2174/18723128100116021215063026648057]Search in Google Scholar
[Nevitt, S.J., Jones, A.P., Howard, J., 2017. Hydroxyurea (hydroxycarbamide) for sickle cell disease. Cochrane Database Syst. Rev. 4, CD002202. https://doi.org/10.1002/14651858.CD002202.pub210.1002/14651858.CD002202.pub2647825928426137]Search in Google Scholar
[Ngozi Awa Imaga, 2013. Phytomedicines and nutraceuticals: Alternative therapeutics for sickle cell anemia. Sci. World J. 2013, 12. https://doi.org/http://dx.doi.org/10.1155/2013/26965910.1155/2013/269659358648923476125]Open DOISearch in Google Scholar
[Okorie, C.P., Nwagha, T., Ejezie, F., 2018. Assessment of some indicators of oxidative stress in nigerian sickle cell anemic patients. Ann. Afr. Med. 17, 11–16. https://doi.org/10.4103/aam.aam_26_1710.4103/aam.aam_26_17581008729363630]Open DOISearch in Google Scholar
[Oslund, R.C., Su, X., Haugbro, M., Kee, J.-M., Esposito, M., David, Y., Wang, B., Ge, E., Perlman, D.H., Kang, Y., Muir, T.W., Rabinowitz, J.D., 2017. Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate. Nat. Chem. Biol. 13, 1081–1087. https://doi.org/10.1038/nchembio.245310.1038/nchembio.2453560544228805803]Open DOISearch in Google Scholar
[Poillon, W.N., Kim, B.C., Labotka, R.J., Hicks, C.U., Kark, J. a, 1995. Antisickling effects of 2,3-diphosphoglycerate depletion. Blood 85, 3289–3296.10.1182/blood.V85.11.3289.bloodjournal85113289]Search in Google Scholar
[Rees, D.C., 2011. The rationale for using hydroxycarbamide in the treatment of sickle cell disease. Haematologica 96, 488–491. https://doi.org/10.3324/haematol.2011.04198810.3324/haematol.2011.041988306922121454878]Open DOISearch in Google Scholar
[Rifkind, J.M., Nagababu, E., Ramasamy, S., Ravi, L.B., 2004. Hemoglobin redox reactions and oxidative stress. Redox Rep. 8, 234–237. https://doi.org/10.1179/13510000322500281710.1179/13510000322500281714962355]Search in Google Scholar
[Rowley, C.A., Ikeda, A.K., Seidel, M., Anaebere, T.C., Antalek, M.D., Seamon, C., Conrey, A.K., Mendelsohn, L., Nichols, J., Gorbach, A.M., Kato, G.J., Ackerman, H., 2014. Microvascular oxygen consumption during sickle cell pain crisis. Blood 123, 3101–4. https://doi.org/10.1182/blood-2013-11-53340610.1182/blood-2013-11-533406402341824665133]Open DOISearch in Google Scholar
[Sani, H.L., Malami, I., Hassan, S.W., Alhassan, A.M., Halilu, M.E., Muhammad, A., 2015. Effects of standardized stem bark extract of Mangifera indica L. In wistar rats with 2,4-dinitrophenylhydrazineinduced haemolytic anaemia. Pharmacogn. J. 7. https://doi.org/10.5530/pj.2015.2.210.5530/pj.2015.2.2]Open DOISearch in Google Scholar
[Sedrak, A., Kondamudi, N.P., 2018. Sickle Cell Disease, StatPearls. StatPearls Publishing.]Search in Google Scholar
[Silva DGH, Belini Junior E, de Almeida EA, B.-D.C., 2013. Oxidative stress in sickle cell disease: An overview of erythrocyte redox metabolism and current antioxidant therapeutic strategies. Free Radic. Biol. Med. 65, 1101–1109. https://doi.org/doi:10.1016/j.freeradbiomed.2013.08.18110.1016/j.freeradbiomed.2013.08.18124002011]Open DOISearch in Google Scholar
[Teixeira, R.S., Terse-Ramos, R., Ferreira, T.A., Machado, V.R., Perdiz, M.I., Lyra, I.M., Nascimento, V.L., Boa-Sorte, N., Andrade, B.B., Ladeia, A.M., 2017. Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia. PLoS One 12, e0184076. https://doi.org/10.1371/journal.pone.018407610.1371/journal.pone.0184076558091528863145]Open DOISearch in Google Scholar
[Zhang, C., Wang, R., Zhang, G., Gong, D., 2018. Mechanistic insights into the inhibition of quercetin on xanthine oxidase. Int. J. Biol. Macromol. 112, 405–412. https://doi.org/10.1016/j.ijbiomac.2018.01.19010.1016/j.ijbiomac.2018.01.19029410028]Open DOISearch in Google Scholar
[Zheng, Y.-Z., Deng, G., Liang, Q., Chen, D.-F., Guo, R., Lai, R.-C., 2017. Antioxidant Activity of Quercetin and Its Glucosides from Propolis: A Theoretical Study. Sci. Rep. 7, 7543. https://doi.org/10.1038/s41598-017-08024-810.1038/s41598-017-08024-8554890328790397]Open DOISearch in Google Scholar