<abstract xmlns="http://www.w3.org/1999/xhtml">

<sec><h3>Introduction</h3>
<p>One of the most important health problems today is cancer. The aim of this study was to investigate the in vitro effect of yarrow (Y) with known anticarcinogenic effect on Ehrlich ascites tumor (EAT).</p>
</sec>
<sec><h3>Materials and Methods</h3>
<p>The above-ground part (300 g) of Y was macerated with water and extracted three times for 24 hours at 37°C in a shaking water bath. In the study, EAT cells were divided into control, DMSO group 5-FU, 50, 100, 200, 400 and 800 μg/ml YP groups.</p>
</sec>
<sec><h3>Results</h3>
<p>At the end of the hour, it was observed that total apoptosis increased significantly in Y groups (especially 50 μg/ml) compared to the control group (<italic>p&lt;0.05</italic>). It was observed that Y slowed the division of EAT cells (especially 800 μg/ml) by stopping the cell cycle at the G0/G1 stage. It was concluded that Y (especially at high doses) triggered apoptosis by significantly increasing the percentage of total depolarized cells <italic>(p&lt;0.001</italic>) in all three time periods.</p>
</sec>
<sec><h3>Conclusions</h3>
<p>The results obtained showed that Y extract may have an antitumoral effect on EAT cells. It is thought that this study will contribute to studies on cancer treatment.</p>
</sec>
</abstract>

Introduction
One of the most important health problems today is cancer. The aim of this study was to investigate the in vitro effect of yarrow (Y) with known anticarcinogenic effect on Ehrlich ascites tumor (EAT).

Materials and Methods
The above-ground part (300 g) of Y was macerated with water and extracted three times for 24 hours at 37°C in a shaking water bath. In the study, EAT cells were divided into control, DMSO group 5-FU, 50, 100, 200, 400 and 800 μg/ml YP groups.

Results
At the end of the hour, it was observed that total apoptosis increased significantly in Y groups (especially 50 μg/ml) compared to the control group (p<0.05). It was observed that Y slowed the division of EAT cells (especially 800 μg/ml) by stopping the cell cycle at the G0/G1 stage. It was concluded that Y (especially at high doses) triggered apoptosis by significantly increasing the percentage of total depolarized cells (p<0.001) in all three time periods.

Conclusions
The results obtained showed that Y extract may have an antitumoral effect on EAT cells. It is thought that this study will contribute to studies on cancer treatment.

Investigation of the effect of yarrow (<italic>Achillea millefolium</italic>) on Ehrlich ascites tumor

Department of Nutrition and Dietetics, Faculty of Health Sciences

Lokman Hekim University School of Medicine

Postępy Higieny i Medycyny Doświadczalnej

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Investigation of the effect of yarrow () on Ehrlich ascites tumor

Introduction
One of the most important health problems today is cancer. The aim of this study was to investigate the in vitro effect of yarrow (Y) with known...

Investigation of the effect of yarrow (Achillea millefolium) on Ehrlich ascites tumor

Article Category: Original Study

Publié en ligne: 20 oct. 2022

Pages: 431 - 443

Reçu: 26 juil. 2021

Accepté: 23 janv. 2022

DOI: https://doi.org/10.2478/ahem-2022-0028

Mots clés
animal, cell, yarrow, EAT, apoptosis

© 2022 Mustafa Nisari et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Investigation of the effect of yarrow (Achillea millefolium) on Ehrlich ascites tumor

Article Category: Original Study

Publié en ligne: 20 oct. 2022

Pages: 431 - 443

Reçu: 26 juil. 2021

Accepté: 23 janv. 2022

DOI: https://doi.org/10.2478/ahem-2022-0028

Mots clésanimal, cell, yarrow, EAT, apoptosis

© 2022 Mustafa Nisari et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Mots clés
animal, cell, yarrow, EAT, apoptosis