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The experimental study of the immunomodulating action of Semax and Selank on the model of „social” stress

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Influence of Semax and Selank on the leukocyte counts of animals in conditions of “social” stress.

Indicators (M ± m) Control „Social” stress „Social” stress + Semax (100 mcg/kg/day) „Social” stress + Selank (100 mcg/kg/day)
Experimental group (n = 10)
Animals with an aggressive type of behaviour
Total number of leukocytes, ×109/l 11.7 ± 0.93 8.3 ± 0.82* 12.5 ± 1.04## 15.7 ± 1.24###
Eosinophils, % 2.8 ± 0.33 2.0 ± 0.21* 2.8 ± 0.24# 2.4 ± 0.20
Band neutrophils, % 2.2 ± 0.23 3.4 ± 0.25** 2.3 ± 0.30# 2.1 ± 0.36#
Segmented neutrophils, % 12.7 ± 1.59 26.7 ± 1.81*** 13.3 ± 2.0### 16.0 ± 2.10##
Lymphocytes,% 81.5 ± 5.95 67.1 ± 4.27 80.8 ± 4.9 78.7 ± 4.87
Monocytes, % 0.83 ± 0.15 0.71 ± 0.10 0.81 ± 0.10 0.86 ± 0.11
Animals with a submissive type of behaviour
Total number of leukocytes, ×109/l 11.7 ± 0.93 8.4 ± 0.77* 11.6 ± 1.01# 13.1 ± 0.58###
Eosinophils, % 2.8 ± 0.33 1.6 ± 0.11## 2.3 ± 0.31# 2.1 ± 0.22#
Band neutrophils, % 2.2 ± 0.23 4.1 ± 0.40** 2.0 ± 0.24### 2.1 ± 0.37##
Segmented neutrophils, % 12.7 ± 1.59 27.1 ± 2.11*** 16.4 ± 2.1## 16.1 ± 2.57##
Lymphocytes,% 81.5 ± 5.95 66.4 ± 4.77 78.5 ± 4.4 78.9 ± 4.87
Monocytes, % 0.83 ± 0.15 0.71 ± 0.10 0.82 ± 0.14 0.86 ± 0.11

The influence of Semax and Selank on the formation of DTH and DAT in conditions of “social” stress.

Experimental groups (n = 10) Index DTH, % Titre of antibodies in DAT, log2
Indicators (M ± m)
Animals with an aggressive type of behavior
Control 30.83 ± 3.52 224.77 ± 23.27
„Social” stress 16.57 ± 1.75** 40.46 ± 5.81***
„Social” stress + Semax (100 mcg /kg/day) 25.20 ± 2.46* 152.60 ± 18.62###
„Social” stress + Selank(100 mcg /kg/day) 30.38 ± 3.48## 210.56 ± 22.54###
Animals with a submissive type of behavior
Control 30.83 ± 3.52 224.77 ± 23.27
„Social” stress 20.78 ± 2.54* 103.55 ± 11.64***
„Social” stress + Semax (100 mcg /kg/day) 27.40 ± 2.76 148.21 ± 18.81#
„Social” stress + Selank (100 mcg /kg/day) 28.26 ± 2.66# 231.19 ± 34.91##

Influence of Semax and Selank on the phagocytic activity of neutrophils in conditions of “social” stress.

Experimental groups (n = 10) Phagocytic index Phagocytic number, %
Indicators (M ± m)
Animals with an aggressive type of behaviour
Control 17.7 ± 1.68 53.3 ± 3.66
„Social” stress 21.0 ± 1.85 74.3 ± 7.37*
„Social” stress + Semax (100 mcg /kg/day) 16.8 ± 1.23 53.2 ± 4.63#
„Social” stress + Selank (100 mcg /kg/day) 16.3 ± 1.87 57.6 ± 4.23
Animals with a submissive type of behaviour
Control 17.7 ± 1.68 53.3 ± 3.66
„Social” stress 22.9 ± 1.61* 63.7 ± 4.73
„Social” stress + Semax (100 mcg /kg/day) 10.8 ± 1.30### 44.6 ± 4.53#
„Social” stress + Selank (100 mcg /kg/day) 18.4 ± 1.58 50.5 ± 4.65
eISSN:
2453-6725
Langue:
Anglais
Périodicité:
2 fois par an
Sujets de la revue:
Pharmacy, other