The experimental study of the immunomodulating action of Semax and Selank on the model of „social” stress

Indicators (M ± m)	Control	„Social” stress	„Social” stress + Semax (100 mcg/kg/day)	„Social” stress + Selank (100 mcg/kg/day)
Experimental group (n = 10)	Control	„Social” stress	„Social” stress + Semax (100 mcg/kg/day)	„Social” stress + Selank (100 mcg/kg/day)
Animals with an aggressive type of behaviour
Total number of leukocytes, ×10⁹/l	11.7 ± 0.93	8.3 ± 0.82^*	12.5 ± 1.04^##	15.7 ± 1.24^###
Eosinophils, %	2.8 ± 0.33	2.0 ± 0.21^*	2.8 ± 0.24^#	2.4 ± 0.20
Band neutrophils, %	2.2 ± 0.23	3.4 ± 0.25^**	2.3 ± 0.30^#	2.1 ± 0.36^#
Segmented neutrophils, %	12.7 ± 1.59	26.7 ± 1.81^***	13.3 ± 2.0^###	16.0 ± 2.10^##
Lymphocytes,%	81.5 ± 5.95	67.1 ± 4.27	80.8 ± 4.9	78.7 ± 4.87
Monocytes, %	0.83 ± 0.15	0.71 ± 0.10	0.81 ± 0.10	0.86 ± 0.11
Animals with a submissive type of behaviour
Total number of leukocytes, ×10⁹/l	11.7 ± 0.93	8.4 ± 0.77^*	11.6 ± 1.01^#	13.1 ± 0.58^###
Eosinophils, %	2.8 ± 0.33	1.6 ± 0.11^##	2.3 ± 0.31^#	2.1 ± 0.22^#
Band neutrophils, %	2.2 ± 0.23	4.1 ± 0.40^**	2.0 ± 0.24^###	2.1 ± 0.37^##
Segmented neutrophils, %	12.7 ± 1.59	27.1 ± 2.11^***	16.4 ± 2.1^##	16.1 ± 2.57^##
Lymphocytes,%	81.5 ± 5.95	66.4 ± 4.77	78.5 ± 4.4	78.9 ± 4.87
Monocytes, %	0.83 ± 0.15	0.71 ± 0.10	0.82 ± 0.14	0.86 ± 0.11

Experimental groups (n = 10)	Index DTH, %	Titre of antibodies in DAT, log2
Indicators (M ± m)	Index DTH, %	Titre of antibodies in DAT, log2
Animals with an aggressive type of behavior
Control	30.83 ± 3.52	224.77 ± 23.27
„Social” stress	16.57 ± 1.75^**	40.46 ± 5.81^***
„Social” stress + Semax (100 mcg /kg/day)	25.20 ± 2.46^*	152.60 ± 18.62^###
„Social” stress + Selank(100 mcg /kg/day)	30.38 ± 3.48^##	210.56 ± 22.54^###
Animals with a submissive type of behavior
Control	30.83 ± 3.52	224.77 ± 23.27
„Social” stress	20.78 ± 2.54^*	103.55 ± 11.64^***
„Social” stress + Semax (100 mcg /kg/day)	27.40 ± 2.76	148.21 ± 18.81^#
„Social” stress + Selank (100 mcg /kg/day)	28.26 ± 2.66^#	231.19 ± 34.91^##

Experimental groups (n = 10)	Phagocytic index	Phagocytic number, %
Indicators (M ± m)	Phagocytic index	Phagocytic number, %
Animals with an aggressive type of behaviour
Control	17.7 ± 1.68	53.3 ± 3.66
„Social” stress	21.0 ± 1.85	74.3 ± 7.37^*
„Social” stress + Semax (100 mcg /kg/day)	16.8 ± 1.23	53.2 ± 4.63^#
„Social” stress + Selank (100 mcg /kg/day)	16.3 ± 1.87	57.6 ± 4.23
Animals with a submissive type of behaviour
Control	17.7 ± 1.68	53.3 ± 3.66
„Social” stress	22.9 ± 1.61^*	63.7 ± 4.73
„Social” stress + Semax (100 mcg /kg/day)	10.8 ± 1.30^###	44.6 ± 4.53^#
„Social” stress + Selank (100 mcg /kg/day)	18.4 ± 1.58	50.5 ± 4.65