<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.</p></abstract>

This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.

Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared...

Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

Publié en ligne: 13 mai 2020

Pages: 443 - 463

Accepté: 03 déc. 2019

DOI: https://doi.org/10.2478/acph-2020-0038

Mots clés
process analytical technology (PAT), roller compaction, near-infrared (NIR) spectroscopy, near-infrared chemical imaging (NIR-CI), microwave resonance technology, thermal effusivity

© 2020 Aleša Dular Vovko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

Publié en ligne: 13 mai 2020

Pages: 443 - 463

Accepté: 03 déc. 2019

DOI: https://doi.org/10.2478/acph-2020-0038

Mots clésprocess analytical technology (PAT), roller compaction, near-infrared (NIR) spectroscopy, near-infrared chemical imaging (NIR-CI), microwave resonance technology, thermal effusivity

© 2020 Aleša Dular Vovko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
process analytical technology (PAT), roller compaction, near-infrared (NIR) spectroscopy, near-infrared chemical imaging (NIR-CI), microwave resonance technology, thermal effusivity