<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.</p></abstract>

This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared spectroscopy, near-infrared spectroscopy coupled with chemical imaging, microwave resonance technology, thermal effusivity and various particle imaging techniques have been used for developing at-, off-, on- and in-line models for predicting critical quality attributes of ribbons and subsequent granules and tablets. The common goal of all these methods is improved process understanding and process control, and thus improved production of high-quality products. This article reviews the work of several researchers in this field, comparing and critically evaluating their achievements.

Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

This article presents an overview of using process analytical technology in monitoring the roller compaction process. In the past two decades, near-infrared...

Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

Published Online: May 13, 2020

Page range: 443 - 463

Accepted: Dec 03, 2019

DOI: https://doi.org/10.2478/acph-2020-0038

Keywords
process analytical technology (PAT), roller compaction, near-infrared (NIR) spectroscopy, near-infrared chemical imaging (NIR-CI), microwave resonance technology, thermal effusivity

© 2020 Aleša Dular Vovko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Process analytical technology tools for process control of roller compaction in solid pharmaceuticals manufacturing

Published Online: May 13, 2020

Page range: 443 - 463

Accepted: Dec 03, 2019

DOI: https://doi.org/10.2478/acph-2020-0038

Keywordsprocess analytical technology (PAT), roller compaction, near-infrared (NIR) spectroscopy, near-infrared chemical imaging (NIR-CI), microwave resonance technology, thermal effusivity

© 2020 Aleša Dular Vovko et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
process analytical technology (PAT), roller compaction, near-infrared (NIR) spectroscopy, near-infrared chemical imaging (NIR-CI), microwave resonance technology, thermal effusivity