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Figure 1:
A Original recording of isometric contractions of A. suum muscle flap induced by increasing concentrations of pyrantel and the effect of GABA (3 μM) and Carvacrol (100 μM) on those contractions; B the concentration-response plot for pyrantel control (n = 6, blue), in the presence of GABA 3 μM (n = 6, green), in the presence of GABA and Carvacrol 100 μM (n = 6, red) and after washing (n = 6, dashed black) (mean ± S.E.).
Figure 2:
A Original recording of isometric contractions of A. suum muscle flap induced by increasing concentrations of bephenium and the effect of GABA (3 μM) and Carvacrol (100 μM) on those contractions; B the concentration-response plot for bephenium control (n = 6, blue), in the presence of GABA 3 μM (n = 6, green), in the presence of GABA and Carvacrol 100 μM (n = 6, red) and after washing (n = 6, dashed black) (mean ± S.E.).
Figure 3:
A Original recording of isometric contractions of A. suum muscle flap induced by increasing concentrations of morantel and the effect of GABA (3 μM) and carvacrol (100 μM) on those contractions; B the concentration-response plot for morantel control (n = 6, blue), in the presence of GABA 3 μM (n = 6, green), in the presence of GABA and carvacrol 100 μM (n = 6, red) and after washing (n = 6, dashed black) (mean ± S.E.).
EC50 (±S.E.) values of pyrantel, bephenium, and morantel in the presence of GABA and carvacrol.
Control
GABA 3 μM
GABA 3 μM + Carvacrol 100 μM
Wash
Pyrantel (nM)
8.44 ± 1.56
28.11 ± 1.61****
44.62 ± 2.70****++++
20.51 ± 2.34***oooo
Bephenium (μM)
0.62 ± 0.11
0.96 ± 0.21
1.40 ± 0.12***
1.32 ± 0.09**
Morantel (nM)
3.72 ± 1.73
5.69 ± 2.12
7.94 ± 2.35
15.81 ± 4.03*+
R
max (g ± S.E.) values of pyrantel, bephenium, and morantel in the presence of GABA and carvacrol.