<abstract xmlns="http://www.w3.org/1999/xhtml">The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. The P antigen is intimately related to the Pkand NOR antigens discussed in the review about the P1PK blood group system. Naturally occurring anti-P is present in the serum of individuals with the rare globoside-deficient phenotypes p, P1k, and P2kand has been implicated in hemolytic transfusion reactions as well as unfavorable outcomes of pregnancy. The molecular genetic basis of globoside deficiency is absence of functional P synthase as a result of mutations at the <italic>B3GALNT1</italic>locus. Other related glycolipid structures, the LKE and PX2 antigens, remain in the GLOB blood group collection pending further evidence about the genes and gene products responsible for their synthesis. <italic><bold>Immunohematology</bold></italic><bold>2013;29:19–24.</bold></abstract>

The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals worldwide. The P antigen is intimately related to the Pkand NOR antigens discussed in the review about the P1PK blood group system. Naturally occurring anti-P is present in the serum of individuals with the rare globoside-deficient phenotypes p, P1k, and P2kand has been implicated in hemolytic transfusion reactions as well as unfavorable outcomes of pregnancy. The molecular genetic basis of globoside deficiency is absence of functional P synthase as a result of mutations at the B3GALNT1locus. Other related glycolipid structures, the LKE and PX2 antigens, remain in the GLOB blood group collection pending further evidence about the genes and gene products responsible for their synthesis. Immunohematology2013;29:19–24.

An update on the GLOB blood group system and collection

Department of Clinical Immunology and Transfusion Medicine

Immunohematology

{"article-title":"An update on the GLOB blood group system and collection"}

The P blood group antigen of the GLOB system is a glycolipid structure, also known as globoside, on the red blood cells (RBCs) of almost all individuals...

An update on the GLOB blood group system and collection

Article Category: Review

Publié en ligne: 01 déc. 2019

Pages: 19 - 24

DOI: https://doi.org/10.21307/immunohematology-2019-119

© 2013 Å. Hellberg, et al., published by Sciendo