This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Abdel-Aziz H., Wadie W., Abdallah D.M., Lentzen G., Khayyal M.T.: Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis. Phytomedicine 20, 585–591 (2013)Abdel-AzizH.WadieW.AbdallahD.M.LentzenG.KhayyalM.T.Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis20585591201310.1016/j.phymed.2013.01.009Search in Google Scholar
Rajan L.A., Joseph T.C., Thampuran N., James R., Kumar K.A., Viswanathan C., Bansal K.C.: Cloning and heterologous expression of ectoine biosynthesis genes from Bacillus halodurans in Escherichia coli. Biotechnol. Lett. 30, 1403–1407 (2008)RajanL.A.JosephT.C.ThampuranN.JamesR.KumarK.A.ViswanathanC.BansalK.C.Cloning and heterologous expression of ectoine biosynthesis genes from Bacillus halodurans in Escherichia coli3014031407200810.1007/s10529-008-9688-3Search in Google Scholar
Andrei A-Ş., Banciu H.L., Oren A.: Living with salt: metabolic and phylogenetic diversity of archaea inhabiting saline ecosystems. FEMS Microbiol. Lett. 330, 1–9 (2012)AndreiA-Ş.BanciuH.L.OrenA.Living with salt: metabolic and phylogenetic diversity of archaea inhabiting saline ecosystems33019201210.1111/j.1574-6968.2012.02526.xSearch in Google Scholar
Anzali S., Von Heydebreck A., Herget T.: Elucidation of the antiaging effects of ectoine using cdna microarray analysis and signaling pathway evaluation. Int. J. Cosmet. Sci. 32, 319–319 (2010)AnzaliS.Von HeydebreckA.HergetT.Elucidation of the antiaging effects of ectoine using cdna microarray analysis and signaling pathway evaluation32319319201010.1111/j.1468-2494.2010.00589_4.xSearch in Google Scholar
Baliarda A., Robert H., Jebbar M., Blanco C., Deschamps A., Le Marrec C.: Potential osmoprotectants for the lactic acid bacteria Pediococcus pentosaceus and Tetragenococcus halophila. Int. J. Food. Microbiol. 84, 13–20 (2003)BaliardaA.RobertH.JebbarM.BlancoC.DeschampsA.Le MarrecC.Potential osmoprotectants for the lactic acid bacteria Pediococcus pentosaceus and Tetragenococcus halophila841320200310.1016/S0168-1605(02)00388-4Search in Google Scholar
Barth S., Huhn M., Matthey B., Klimka A., Galinski E.A., Engert A.: Compatible-solute-supported periplasmic expression of functional recombinant proteins under stress conditions. Appl. Environ. Microbiol. 66, 1572–1579 (2000)BarthS.HuhnM.MattheyB.KlimkaA.GalinskiE.A.EngertA.Compatible-solute-supported periplasmic expression of functional recombinant proteins under stress conditions6615721579200010.1128/AEM.66.4.1572-1579.20009202510742244Search in Google Scholar
Becker J., Schäfer R., Kohlstedt M., Harder B.J., Borchert N.S., Stöveken N., Bremer E., Wittmann C.: Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine. Microb. Cell Fact. 12, 110 (2013)BeckerJ.SchäferR.KohlstedtM.HarderB.J.BorchertN.S.StövekenN.BremerE.WittmannC.Systems metabolic engineering of Corynebacterium glutamicum for production of the chemical chaperone ectoine12110201310.1186/1475-2859-12-110422576124228689Search in Google Scholar
Bernard T., Jebbar M., Rassouli Y., Himdikabbab S., Hamelin J., Blanco C.: Ectoine accumulation and osmotic regulation in Brevibacterium linens. J. Gen. Microbiol. 139, 129–136 (1993)BernardT.JebbarM.RassouliY.HimdikabbabS.HamelinJ.BlancoC.Ectoine accumulation and osmotic regulation in Brevibacterium linens139129136199310.1099/00221287-139-1-129Search in Google Scholar
Bersch S., Vangala M., Schwarz T., Kaufmann M.: Protection of antibodies against proteolytic degradation by compatible solutes (in) 2nd international conference on protein stabilisation/biomolecule stabilisation, Lissabon, 2000BerschS.VangalaM.SchwarzT.KaufmannM.Protection of antibodies against proteolytic degradation by compatible solutes(in)2000Search in Google Scholar
Beyer N., Driller H.: Ectoin: a innovative, multi-functional active substance for the cosmetic industry. SÖfw-journal 126, 26–29 (2000)BeyerN.DrillerH.Ectoin: a innovative, multi-functional active substance for the cosmetic industry12626292000Search in Google Scholar
Bilstein A., Lentzen G., Tolba R., Quesnel F.: Organ storage solution. Google Patents. https://patents.google.com/patent/US20150104781A1/en (Dostęp 2.02.2019), (2015)BilsteinA.LentzenG.TolbaR.QuesnelF.Organ storage solutionhttps://patents.google.com/patent/US20150104781A1/en(Dostęp 2.02.2019)2015Search in Google Scholar
Bissoyi A., Pramanik K.: Effects of non-toxic cryoprotective agents on the viability of cord blood derived MNCs. Cryoletters 34, 453–465 (2013)BissoyiA.PramanikK.Effects of non-toxic cryoprotective agents on the viability of cord blood derived MNCs344534652013Search in Google Scholar
Botta C., Di Giorgio C., Sabatier A.-S., De Méo M.: Genotoxicity of visible light (400–800 nm) and photoprotection assessment of ectoin, l-ergothioneine and mannitol and four sunscreens. J. Photochem. Photobiol. B. Biol. 91, 24–34 (2008)BottaC.Di GiorgioC.SabatierA.-S.De MéoM.Genotoxicity of visible light (400–800 nm) and photoprotection assessment of ectoin, l-ergothioneine and mannitol and four sunscreens912434200810.1016/j.jphotobiol.2008.01.00818325778Search in Google Scholar
Bownik A., Stępniewska Z.: Ectoine as a promising protective agent in humans and animals. Arh. Hig. Rada. Toksikol. 67, 260–265 (2016)BownikA.StępniewskaZ.Ectoine as a promising protective agent in humans and animals67260265201610.1515/aiht-2016-67-283728033102Search in Google Scholar
Bownik A., Stępniewska Z.: Protective effects of bacterial osmo-protectant ectoine on bovine erythrocytes subjected to staphylococcal alpha-haemolysin. Toxicon 99, 130–135 (2015)BownikA.StępniewskaZ.Protective effects of bacterial osmo-protectant ectoine on bovine erythrocytes subjected to staphylococcal alpha-haemolysin99130135201510.1016/j.toxicon.2015.03.022Search in Google Scholar
Bownik A., Stępniewska Z.: Zastosowanie ektoiny jako czynnika ochronnego przed działaniem toksyny bakteryjnej. Patent nr P412197 (2018)BownikA.StępniewskaZ.Zastosowanie ektoiny jako czynnika ochronnego przed działaniem toksyny bakteryjnej2018Search in Google Scholar
Buenger J., Driller H.: Ectoin: An effective natural substance to prevent UVA-induced premature photoaging. Skin Pharmacol. Physiol. 17, 232–237 (2004)BuengerJ.DrillerH.Ectoin: An effective natural substance to prevent UVA-induced premature photoaging17232237200410.1159/000080216Search in Google Scholar
Bunger J.: Ectoin added protection and care for the skin. Euro Cosmet. 7, 22–24 (1999)BungerJ.Ectoin added protection and care for the skin722241999Search in Google Scholar
Buommino E., Schiraldi C., Baroni A., Paoletti I., Lamberti M., De Rosa M., Tufano M.A.: Ectoine from halophilic microorganisms induces the expression of hsp70 and hsp70B’ in human keratinocytes modulating the proinflammatory response. Cell Stress Chaperones 10, 197–203 (2005)BuomminoE.SchiraldiC.BaroniA.PaolettiI.LambertiM.De RosaM.TufanoM.A.Ectoine from halophilic microorganisms induces the expression of hsp70 and hsp70B’ in human keratinocytes modulating the proinflammatory response10197203200510.1379/CSC-101R.1Search in Google Scholar
Bursy J., Kuhlmann A.U., Pittelkow M., Hartmann H., Jebbar M., Pierik A.J., Bremer E.: Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses. Appl. Environ. Microbiol. 74, 7286–7296 (2008)BursyJ.KuhlmannA.U.PittelkowM.HartmannH.JebbarM.PierikA.J.BremerE.Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses7472867296200810.1128/AEM.00768-08Search in Google Scholar
Bursy J., Pierik A.J., Pica N., Bremer E.: Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase. J. Biol. Chem. (2007)BursyJ.PierikA.J.PicaN.BremerE.Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase200710.1074/jbc.M704023200Search in Google Scholar
Cánovas D., Vargas C., Calderón M.I., Ventosa A., Nieto J.J.: Characterization of the genes for the biosynthesis of the compatible solute ectoine in the moderately halophilic bacterium Halomonas elongata DSM 3043. Syst. Appl. Microbiol. 21, 487–497 (1998)CánovasD.VargasC.CalderónM.I.VentosaA.NietoJ.J.Characterization of the genes for the biosynthesis of the compatible solute ectoine in the moderately halophilic bacterium Halomonas elongata DSM 304321487497199810.1016/S0723-2020(98)80060-XSearch in Google Scholar
Cantera S., Lebrero R., Rodríguez E., García-Encina PA., Muñoz R.: Continuous abatement of methane coupled with ectoine production by Methylomicrobium alcaliphilum 20Z in stirred tank reactors: A step further towards greenhouse gas biorefineries. J. Clean. Prod. 152, 134–141 (2017)CanteraS.LebreroR.RodríguezE.García-EncinaPA.MuñozR.Continuous abatement of methane coupled with ectoine production by Methylomicrobium alcaliphilum 20Z in stirred tank reactors: A step further towards greenhouse gas biorefineries152134141201710.1016/j.jclepro.2017.03.123Search in Google Scholar
Cantera S., Lebrero R., Rodríguez S., García-Encina PA., Muñoz R.: Ectoine bio-milking in methanotrophs: A step further towards methane-based bio-refineries into high addedvalue products. Chem. Eng. J. 328, 44–48 (2017)CanteraS.LebreroR.RodríguezS.García-EncinaPA.MuñozR.Ectoine bio-milking in methanotrophs: A step further towards methane-based bio-refineries into high addedvalue products3284448201710.1016/j.cej.2017.07.027Search in Google Scholar
Cantera S., Muñoz R., Lebrero R., López J.C., Rodríguez Y., García-Encina P.A.: Technologies for the bioconversion of methane into more valuable products. Curr. Opin. Biotechnol. 50, 128–135 (2018)CanteraS.MuñozR.LebreroR.LópezJ.C.RodríguezY.García-EncinaP.A.Technologies for the bioconversion of methane into more valuable products50128135201810.1016/j.copbio.2017.12.02129316497Search in Google Scholar
Cruz P.E., Silva A.C., Roldão A., Carmo M., Carrondo M.J.T., Alves P.M.: Screening of novel excipients for improving the stability of retroviral and adenoviral vectors. Biotechnol. Prog. 22, 568–576 (2006)CruzP.E.SilvaA.C.RoldãoA.CarmoM.CarrondoM.J.T.AlvesP.M.Screening of novel excipients for improving the stability of retroviral and adenoviral vectors22568576200610.1021/bp050294y16599578Search in Google Scholar
Detkova E.N., Boltyanskaya Y.V.: Osmoadaptation of haloalkaliphilic bacteria: Role of osmoregulators and their possible practical application. Microbiol. 76, 511–522 (2007)DetkovaE.N.BoltyanskayaY.V.Osmoadaptation of haloalkaliphilic bacteria: Role of osmoregulators and their possible practical application76511522200710.1134/S0026261707050013Search in Google Scholar
Dwivedi M., Brinkkötter M., Harishchandra R.K., Galla H-J.: Biophysical investigations of the structure and function of the tear fluid lipid layers and the effect of ectoine. Part B: Artificial lipid films. Biochim. Biophys. Acta – Biomembr. 1838, 2716–2727 (2014)DwivediM.BrinkkötterM.HarishchandraR.K.GallaH-J.Biophysical investigations of the structure and function of the tear fluid lipid layers and the effect of ectoine. Part B: Artificial lipid films183827162727201410.1016/j.bbamem.2014.05.00724853656Search in Google Scholar
Ectoine / Hydroxyectoine. [http://artimmun.de/fileadmin/ user_upload/temp_jpegs_and_data/raw_material/BioStab_ Ectoin_u_Hydroxyectoin.pdf] (Dostęp 2.02.2019)http://artimmun.de/fileadmin/user_upload/temp_jpegs_and_data/raw_material/BioStab_Ectoin_u_Hydroxyectoin.pdf(Dostęp 2.02.2019)Search in Google Scholar
El Assal R., Demirci U. et al.: Bio-inspired cryo-ink preserves red blood cell phenotype and function during nanoliter vitrification. Adv. Mater. 26, 5815–5822 (2014)El AssalR.DemirciU.Bio-inspired cryo-ink preserves red blood cell phenotype and function during nanoliter vitrification2658155822201410.1002/adma.201400941416150325047246Search in Google Scholar
Empadinhas N., da Costa M.S.: Osmoadaptation mechanisms in prokaryotes: distribution of compatible solutes. Int. Microbiol. 11, 151–161 (2008)EmpadinhasN.da CostaM.S.Osmoadaptation mechanisms in prokaryotes: distribution of compatible solutes111511612008Search in Google Scholar
Galinski E.A., Pfeiffer H-P., Truper H.G.: 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira. Eur. J. Biochem. 149, 135–139 (1985)GalinskiE.A.PfeifferH-P.TruperH.G.1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid. A novel cyclic amino acid from halophilic phototrophic bacteria of the genus Ectothiorhodospira149135139198510.1111/j.1432-1033.1985.tb08903.x3838936Search in Google Scholar
García-Estepa R., Argandoña M., Reina-Bueno M., Capote N., Iglesias-Guerra F., Nieto J.J., Vargas C.: The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobactersalexigens. J. Bacteriol. 188, 3774–3784 (2006)García-EstepaR.ArgandoñaM.Reina-BuenoM.CapoteN.Iglesias-GuerraF.NietoJ.J.VargasC.The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobactersalexigens18837743784200610.1128/JB.00136-06148288516707670Search in Google Scholar
Gołąbczak J.: Biochemiczne, genetyczne i technologiczne podstawy biosyntezy L-lizyny. Biotechnologia 1, 53–70 (2008)GołąbczakJ.Biochemiczne, genetyczne i technologiczne podstawy biosyntezy L-lizyny153702008Search in Google Scholar
Graf R., Anzali S., Buenger J., Pfluecker F., Driller H.: The multifunctional role of ectoine as a natural cell protectant. Clin. Dermatol. 26, 326–333 (2008)GrafR.AnzaliS.BuengerJ.PflueckerF.DrillerH.The multifunctional role of ectoine as a natural cell protectant26326333200810.1016/j.clindermatol.2008.01.00218691511Search in Google Scholar
Grether-Beck S., Timmer A., Felsner I., Brenden H., Brammertz D., Krutmann J.: Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de dovo synthesis. J. Invest. Dermatol. 125, 545–553 (2005)Grether-BeckS.TimmerA.FelsnerI.BrendenH.BrammertzD.KrutmannJ.Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de dovo synthesis125545553200510.1111/j.0022-202X.2005.23782.x16117797Search in Google Scholar
Guzmán H., Van-Thuoc D., Martín J., Hatti-Kaul R., Quillaguamán J.: A process for the production of ectoine and poly(3-hydroxybutyrate) by Halomonas boliviensis. Appl. Microbiol. Biotechnol. 84, 1069–1077 (2009)GuzmánH.Van-ThuocD.MartínJ.Hatti-KaulR.QuillaguamánJ.A process for the production of ectoine and poly(3-hydroxybutyrate) by Halomonas boliviensis8410691077200910.1007/s00253-009-2036-219466403Search in Google Scholar
Hahn M.B., Uhlig F., Solomun T., Smiatek J., Sturm H.: Combined influence of ectoine and salt: spectroscopic and numerical evidence for compensating effects on aqueous solutions. Phys. Chem. Chem. Phys. 18, 28398–28402 (2016)HahnM.B.UhligF.SolomunT.SmiatekJ.SturmH.Combined influence of ectoine and salt: spectroscopic and numerical evidence for compensating effects on aqueous solutions182839828402201610.1039/C6CP05417J27722327Search in Google Scholar
Hai T., Oppermann-Sanio F.B., Steinbüchel A.: Molecular characterization of a thermostable cyanophycin synthetase from the thermophilic cyanobacterium Synechococcus sp. strain MA19 and in vitro synthesis of cyanophycin and related polyamides. Appl. Environ. Microbiol. 68, 93–101 (2002)HaiT.Oppermann-SanioF.B.SteinbüchelA.Molecular characterization of a thermostable cyanophycin synthetase from the thermophilic cyanobacterium Synechococcus sp. strain MA19 and in vitro synthesis of cyanophycin and related polyamides6893101200210.1128/AEM.68.1.93-101.200212657411772614Search in Google Scholar
Harishchandra R.K., Wulff S., Lentzen G., Neuhaus T., Galla H-J.: The effect of compatible solute ectoines on the structural organization of lipid monolayer and bilayer membranes. Biophys. Chem. 150, 37–46 (2010)HarishchandraR.K.WulffS.LentzenG.NeuhausT.GallaH-J.The effect of compatible solute ectoines on the structural organization of lipid monolayer and bilayer membranes1503746201010.1016/j.bpc.2010.02.007Search in Google Scholar
Heinrich U., Garbe B., Tronnier H.: In vivo Assessment of Ectoin: A randomized, vehicle-controlled clinical trial. Skin Pharmacol. Physiol. 20, 211–218 (2007)HeinrichU.GarbeB.TronnierH.In vivo Assessment of Ectoin: A randomized, vehicle-controlled clinical trial20211218200710.1159/000103204Search in Google Scholar
Held C., Neuhaus T., Sadowski G.: Compatible solutes: Thermodynamic properties and biological impact of ectoines and prolines. Biophys. Chem. 152, 28–39 (2010)HeldC.NeuhausT.SadowskiG.Compatible solutes: Thermodynamic properties and biological impact of ectoines and prolines1522839201010.1016/j.bpc.2010.07.003Search in Google Scholar
Hoymann H.G., Bilstein A., Bernal F., Stoehr T., Lentzen G.: Therapeutic effect of ectoine in an experimental model of allergic asthma. (in) XXVIII Congress of the European Academy of Allergy and Clinical Immunology. Warshaw (2009)HoymannH.G.BilsteinA.BernalF.StoehrT.LentzenG.Therapeutic effect of ectoine in an experimental model of allergic asthma(in)Warshaw2009Search in Google Scholar
Inbar L., Lapidot A.: The structure and biosynthesis of new tetrahydropyrimidine derivatives in actinomycin D producer Streptomyces parvulus. Use of 13C-and 15N-labeled L-glutamate. J. Biol. Chem. 263, 16014–1622 (1988)InbarL.LapidotA.The structure and biosynthesis of new tetrahydropyrimidine derivatives in actinomycin D producer Streptomyces parvulus. Use of 13C-and 15N-labeled L-glutamate263160141622198810.1016/S0021-9258(18)37550-1Search in Google Scholar
Yu I., Jindo Y., Nagaoka M.: Microscopic understanding of preferential exclusion of compatible solute ectoine: direct interaction and hydration alteration. J. Phys. Chem. B. 111, 10231–10238 (2007)YuI.JindoY.NagaokaM.Microscopic understanding of preferential exclusion of compatible solute ectoine: direct interaction and hydration alteration1111023110238200710.1021/jp068367z17676787Search in Google Scholar
Jakubowska A.: Wiązanie jonów na granicy faz oraz specyficzne efekty jonowe. Wiadomości Chem. 193–208 (2012)JakubowskaA.Wiązanie jonów na granicy faz oraz specyficzne efekty jonowe1932082012Search in Google Scholar
Kanapathipillai M., Ku S.H., Girigoswami K., Park C.B.: Small stress molecules inhibit aggregation and neurotoxicity of prion peptide 106–126. Biochem. Biophys Res. Commun. 365, 808–813 (2008)KanapathipillaiM.KuS.H.GirigoswamiK.ParkC.B.Small stress molecules inhibit aggregation and neurotoxicity of prion peptide 106–126365808813200810.1016/j.bbrc.2007.11.07418039468Search in Google Scholar
Kanapathipillai M., Lentzen G., Sierks M., Park C.B.: Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer’s β-amyloid. FEBS Lett. 579, 4775–4780 (2005)KanapathipillaiM.LentzenG.SierksM.ParkC.B.Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer’s β-amyloid57947754780200510.1016/j.febslet.2005.07.05716098972Search in Google Scholar
Khmelenina V.N., Kalyuzhnaya M.G., Starostina N.G., Suzina N.E., Trotsenko Y.A.: Isolation and characterization of halotolerant alkaliphilic methanotrophic bacteria from Tuva Soda Lakes. Curr. Microbiol. 35, 257–261 (1997)KhmeleninaV.N.KalyuzhnayaM.G.StarostinaN.G.SuzinaN.E.TrotsenkoY.A.Isolation and characterization of halotolerant alkaliphilic methanotrophic bacteria from Tuva Soda Lakes35257261199710.1007/s002849900249Search in Google Scholar
Khmelenina V.N., Sakharovskii V.G., Reshetnikov A.S., Trotsenko Y.A.: Synthesis of osmoprotectants by halophilic and alkaliphilic methanotrophs. Microbiology 69, 381–386 (2000)KhmeleninaV.N.SakharovskiiV.G.ReshetnikovA.S.TrotsenkoY.A.Synthesis of osmoprotectants by halophilic and alkaliphilic methanotrophs69381386200010.1007/BF02756759Search in Google Scholar
Khmelenina V.N., Suzina N.E., Trotsenko Y.A.: Surface layers of methanotrophic bacteria. Microbiology 82, 529–541 (2013)KhmeleninaV.N.SuzinaN.E.TrotsenkoY.A.Surface layers of methanotrophic bacteria82529541201310.1134/S0026261713050068Search in Google Scholar
Khmelenina V.N., Mustakhimov I.I., Reshetnikov A.S., Kalyuzhnaya M.G., Trotsenko Y.: Genetic and biochemical aspects of ectoine biosynthesis in moderately halophilic and halotolerant methylotrophic bacteria. Am. J. Agric. Biol. Sci. 5, 446–458 (2010)KhmeleninaV.N.MustakhimovI.I.ReshetnikovA.S.KalyuzhnayaM.G.TrotsenkoY.Genetic and biochemical aspects of ectoine biosynthesis in moderately halophilic and halotolerant methylotrophic bacteria5446458201010.3844/ajabssp.2010.446.458Search in Google Scholar
Khurana R., Coleman C., Ionescu-Zanetti C., Carter S.A., Krishna V., Grover R.K., Roy R., Singh S.: Mechanism of thioflavin T binding to amyloid fibrils. J. Struct. Biol. 151, 229–238 (2005)KhuranaR.ColemanC.Ionescu-ZanettiC.CarterS.A.KrishnaV.GroverR.K.RoyR.SinghS.Mechanism of thioflavin T binding to amyloid fibrils151229238200510.1016/j.jsb.2005.06.006Search in Google Scholar
Kolp S., Pietsch M., Galinski E.A., Gütschow M.: Compatible solutes as protectants for zymogens against proteolysis. Biochim. Biophys. Acta. Proteins. Proteomics 1764, 1234–1242 (2006)KolpS.PietschM.GalinskiE.A.GütschowM.Compatible solutes as protectants for zymogens against proteolysis176412341242200610.1016/j.bbapap.2006.04.015Search in Google Scholar
Kuhlmann A.U., Bremer E.: Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp. Appl. Environ. Microbiol. 68, 772–783 (2002)KuhlmannA.U.BremerE.Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp68772783200210.1128/AEM.68.2.772-783.2002Search in Google Scholar
Kunte H., Lentzen G., Galinski E.: Industrial production of the cell protectant ectoine: protection mechanisms, processes, and products. Curr. Biotechnol. 3, 10–25 (2014)KunteH.LentzenG.GalinskiE.Industrial production of the cell protectant ectoine: protection mechanisms, processes, and products31025201410.2174/22115501113026660037Search in Google Scholar
Kurz M.: Compatible solute influence on nucleic acids: Many questions but few answers. Saline Systems 4, 6 (2008)KurzM.Compatible solute influence on nucleic acids: Many questions but few answers46200810.1186/1746-1448-4-6Search in Google Scholar
Lapidot A., Ben-Asher E., Eisenstein M.: Tetrahydropyrimidine derivatives inhibit binding of a Tat-like, arginine-containing peptide, to HIV TAR RNA in vitro. FEBS Lett. 367, 33–38 (1995)LapidotA.Ben-AsherE.EisensteinM.Tetrahydropyrimidine derivatives inhibit binding of a Tat-like, arginine-containing peptide, to HIV TAR RNA in vitro3673338199510.1016/0014-5793(95)00514-ASearch in Google Scholar
Leclerc J., Benoiton L.: On the selectivity of acylation of unprotected diamino acids. Can. J. Chem. 46, 1047–1051 (1968)LeclercJ.BenoitonL.On the selectivity of acylation of unprotected diamino acids4610471051196810.1139/v68-177Search in Google Scholar
Lentzen G., Neuhaus T.: Synthesis of cyclic amidines. U.S. Patent No. 8,598,346. Washington, DC: U.S. Patent and Trademark Office (2013)LentzenG.NeuhausT.Synthesis of cyclic amidines.Washington, DCU.S. Patent and Trademark Office2013Search in Google Scholar
Libudzisz Z., Kowal K.: Mikrobiologia techniczna. Wydaw. PŁ. (2000)LibudziszZ.KowalK.2000Search in Google Scholar
Lippert K., Galinski E.: Enzyme stabilization be ectoine-type compatible solutes: protection against heating, freezing and drying. Appl. Microbiol. Biotechnol. 37, 61–65 (1992)LippertK.GalinskiE.Enzyme stabilization be ectoine-type compatible solutes: protection against heating, freezing and drying376165199210.1007/BF00174204Search in Google Scholar
Louis P., Truper H.G., Galinski E.A.: Survival of Escherichia coli during drying and storage in the presence of compatible solutes. Appl. Microbiol. Biotechnol. 41, 684–688 (1994)LouisP.TruperH.G.GalinskiE.A.Survival of Escherichia coli during drying and storage in the presence of compatible solutes41684688199410.1007/BF00167285Search in Google Scholar
Malin G., Lapidot A.: Induction of synthesis of tetrahydropyrimidine derivatives in Streptomyces strains and their effect on Escherichia coli in response to osmotic and heat stress. J. Bacteriol. 178, 385–395 (1996)MalinG.LapidotA.Induction of synthesis of tetrahydropyrimidine derivatives in Streptomyces strains and their effect on Escherichia coli in response to osmotic and heat stress178385395199610.1128/jb.178.2.385-395.1996Search in Google Scholar
Manzanera M., García de Castro A., Tøndervik A., Rayner-Brandes M., Strø, m A.R., Tunnacliffe A.: Hydroxyectoine is superior to trehalose for anhydrobiotic engineering of Pseudomonas putida KT2440. Appl. Environ. Microbiol. 68, 4328–4333 (2002)ManzaneraM.García de CastroA.TøndervikA.Rayner-BrandesM., Strø, mA.R.TunnacliffeA.Hydroxyectoine is superior to trehalose for anhydrobiotic engineering of Pseudomonas putida KT24406843284333200210.1128/AEM.68.9.4328-4333.2002Search in Google Scholar
Manzanera M., Vilchez S., Tunnacliffe A.: High survival and stability rates of Escherichia coli dried in hydroxyectoine. FEMS Microbiol Lett. 233, 347–352 (2004)ManzaneraM.VilchezS.TunnacliffeA.High survival and stability rates of Escherichia coli dried in hydroxyectoine233347352200410.1111/j.1574-6968.2004.tb09502.xSearch in Google Scholar
Manzanera M., Vilchez S., Tunnacliffe A.: Plastic encapsulation of stabilized Escherichia coli and Pseudomonas putida. Appl. Environ. Microbiol. 70, 3143–3145 (2004)ManzaneraM.VilchezS.TunnacliffeA.Plastic encapsulation of stabilized Escherichia coli and Pseudomonas putida7031433145200410.1128/AEM.70.5.3143-3145.2004Search in Google Scholar
Mascellani N., Volinia S. et al.: Compatible solutes from hyperthermophiles improve the quality of DNA microarrays. BMC Biotechnol. 7, 82 (2007)MascellaniN.VoliniaS.Compatible solutes from hyperthermophiles improve the quality of DNA microarrays782200710.1186/1472-6750-7-82Search in Google Scholar
Maskow T., Kleinsteuber S.: Carbon and energy fluxes during haloadaptation of Halomonas sp. EF11 growing on phenol. Extremophiles 8, 133–1341 (2004)MaskowT.KleinsteuberS.Carbon and energy fluxes during haloadaptation of Halomonas sp. EF11 growing on phenol81331341200410.1007/s00792-003-0372-1Search in Google Scholar
Moghaieb R.E.A., Fujita K. et al.: Characterization of salt tolerance in ectoine-transformed tobacco plants (Nicotiana tabaccum): photosynthesis, osmotic adjustment, and nitrogen partitioning. Plant, Cell Environ. 29, 173–182 (206)MoghaiebR.E.A.FujitaK.Characterization of salt tolerance in ectoine-transformed tobacco plants (Nicotiana tabaccum): photosynthesis, osmotic adjustment, and nitrogen partitioning2917318220610.1111/j.1365-3040.2005.01410.xSearch in Google Scholar
Motitschke L., Driller H., Galinski E.: Ectoin and ectoin derivatives as moisturizers in cosmetics. U.S. Patent No. 6,060,071. Washington, DC: U.S. Patent and Trademark Office (2001)MotitschkeL.DrillerH.GalinskiE.Washington, DCU.S. Patent and Trademark Office2001Search in Google Scholar
Nagata S., Maekawa Y., Ikeuchi T., Wang Y.B., Ishida A.: Effect of compatible solutes on the respiratory activity and growth of Escherichia coli K-12 under NaCl stress. Rep. Res. Inst. Mar. Cargo. Transp. 11, 75–80 (2003)NagataS.MaekawaY.IkeuchiT.WangY.B.IshidaA.Effect of compatible solutes on the respiratory activity and growth of Escherichia coli K-12 under NaCl stress117580200310.1016/S1389-1723(02)80213-4Search in Google Scholar
Pastor J.M., Cánovas M. et al.: Role of central metabolism in the osmoadaptation of the halophilic bacterium Chromohalobacter salexigens. J. Biol Chem. 288, 17769–17781 (2013)PastorJ.M.CánovasM.Role of central metabolism in the osmoadaptation of the halophilic bacterium Chromohalobacter salexigens2881776917781201310.1074/jbc.M113.470567368257623615905Search in Google Scholar
Pastor J.M., Cánovas M. et al.: Ectoines in cell stress protection: Uses and biotechnological production. Biotechnol Adv. 28, 782–801 (2010)PastorJ.M.CánovasM.Ectoines in cell stress protection: Uses and biotechnological production28782801201010.1016/j.biotechadv.2010.06.00520600783Search in Google Scholar
Pech T., Schaefer N. et al.: A natural tetrahydropyrimidine, ectoine, ameliorates ischemia reperfusion injury after intestinal transplantation in rats. Pathobiology 80, 102–110 (2013)PechT.SchaeferN.A natural tetrahydropyrimidine, ectoine, ameliorates ischemia reperfusion injury after intestinal transplantation in rats80102110201310.1159/00034279223108005Search in Google Scholar
Reshetnikov A.S., Khmelenina V.N., Mustakhimov I.I., Kalyuzhnaya M., Lidstrom M., Trotsenko Y.A.: Diversity and phylogeny of the ectoine biosynthesis genes in aerobic, moderately halophilic methylotrophic bacteria. Extremophiles 15, 653–663 (2011)ReshetnikovA.S.KhmeleninaV.N.MustakhimovI.I.KalyuzhnayaM.LidstromM.TrotsenkoY.A.Diversity and phylogeny of the ectoine biosynthesis genes in aerobic, moderately halophilic methylotrophic bacteria15653663201110.1007/s00792-011-0396-x21971967Search in Google Scholar
Reshetnikov A.S., Khmelenina V.N., Mustakhimov I.I., Trotsenko Y.A.: Genes and enzymes of ectoine biosynthesis in halotolerant methanotrophs. 1st edition. Elsevier Inc. (2011)ReshetnikovA.S.KhmeleninaV.N.MustakhimovI.I.TrotsenkoY.A.1st editionElsevier Inc.201110.1016/B978-0-12-386905-0.00002-421419912Search in Google Scholar
Reuter K., Pittelkow M., Bursy J., Heine A., Craan T., Bremer E.: Synthesis of 5-hydroxyectoine from ectoine: Crystal structure of the non-heme iron(II) and 2-oxoglutarate-dependent dioxygenase EctD. PLoS One, 5, e10647 (2010)ReuterK.PittelkowM.BursyJ.HeineA.CraanT.BremerE.Synthesis of 5-hydroxyectoine from ectoine: Crystal structure of the non-heme iron(II) and 2-oxoglutarate-dependent dioxygenase EctD5e10647201010.1371/journal.pone.0010647287103920498719Search in Google Scholar
Robinson M., Visscher M., Laruffa A., Wickett R.: Natural moisturizing factors (NMF) in the stratum corneum (SC). I. Effects of lipid extraction and soaking. J. Cosmet. Sci. 61, 13–22 (2010)RobinsonM.VisscherM.LaruffaA.WickettR.Natural moisturizing factors (NMF) in the stratum corneum (SC). I. Effects of lipid extraction and soaking6113222010Search in Google Scholar
Roychoudhury A., Bieker A., Häussinger D., Oesterhelt F.: Membrane protein stability depends on the concentration of compatible solutes – a single molecule force spectroscopic study. Biol Chem. 394, 1465–1474 (2013)RoychoudhuryA.BiekerA.HäussingerD.OesterheltF.Membrane protein stability depends on the concentration of compatible solutes – a single molecule force spectroscopic study39414651474201310.1515/hsz-2013-017324021596Search in Google Scholar
Ryu J., Kanapathipillai M., Lentzen G., Park C.B.: Inhibition of β-amyloid peptide aggregation and neurotoxicity by α-d-manno sylglycerate, a natural extremolyte. Peptides 29, 578–584 (2008)RyuJ.KanapathipillaiM.LentzenG.ParkC.B.Inhibition of β-amyloid peptide aggregation and neurotoxicity by α-d-manno sylglycerate, a natural extremolyte29578584200810.1016/j.peptides.2007.12.01418304694Search in Google Scholar
Seip B., Galinski E.A., Kurz M.: Natural and engineered hydroxyectoine production based on the Pseudomonas stutzeri ectABCD-ask gene cluster. Appl. Environ. Microbiol. 77, 13681374 (2011)SeipB.GalinskiE.A.KurzM.Natural and engineered hydroxyectoine production based on the Pseudomonas stutzeri ectABCD-ask gene cluster7713681374201110.1128/AEM.02124-10306723321169432Search in Google Scholar
Severin J., Wohlfarth A., Galinski E.A.: The predominant role of recently discovered tetrahydropyrimidines for the osmoadaptation of halophilic eubacteria. Microbiology 138, 1629–1638 (1992)SeverinJ.WohlfarthA.GalinskiE.A.The predominant role of recently discovered tetrahydropyrimidines for the osmoadaptation of halophilic eubacteria138162916381992Search in Google Scholar
Srinivasan P.K., Fet N., Bleilevens C., Afify M., Doorschodt B., Yagi S., Tolba R.H.: Hydroxyectoine ameliorates preservation injury in deceased after cardiac death donors in experimental liver grafts. Ann. Transplant. 19, 165–173 (2014)SrinivasanP.K.FetN.BleilevensC.AfifyM.DoorschodtB.YagiS.TolbaR.H.Hydroxyectoine ameliorates preservation injury in deceased after cardiac death donors in experimental liver grafts19165173201410.12659/AOT.88995824727658Search in Google Scholar
Stępniewska Z., Goraj W., Kuźniar A., Pytlak A., Ciepielski J., Frączek P.: Biosynthesis of ectoine by the methanotrophic bacterial consortium isolated from Bogdanka coalmine (Poland). Appl. Biochem. Microbiol. 50, 594–600 (2014)StępniewskaZ.GorajW., KuźniarA.PytlakA.CiepielskiJ.FrączekP.Biosynthesis of ectoine by the methanotrophic bacterial consortium isolated from Bogdanka coalmine (Poland)50594600201410.1134/S0003683814110039Search in Google Scholar
Stępniewska Z., Kuźniar A., Pytlak, A., Ciepielski J.: Ektoina – przeciwstresowa cząsteczka przyszłości. Kosmos 63, 25–35 (2014)StępniewskaZ.KuźniarA.PytlakA.CiepielskiJ.Ektoina – przeciwstresowa cząsteczka przyszłości6325352014Search in Google Scholar
Strong P.J., Kalyuzhnaya M., Silverman J., Clarke W.P.: A methanotroph-based biorefinery: Potential scenarios for generating multiple products from a single fermentation. Bioresour Technol. 215, 314–323 (2016)StrongP.J.KalyuzhnayaM.SilvermanJ.ClarkeW.P.A methanotroph-based biorefinery: Potential scenarios for generating multiple products from a single fermentation215314323201610.1016/j.biortech.2016.04.09927146469Search in Google Scholar
Sydlik U., Gallitz I., Albrecht C., Abel J., Krutmann J., Unfried K.: The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation. Am. J. Respir. Crit. Care. Med. 180, 29–35 (2009)SydlikU.GallitzI.AlbrechtC.AbelJ.KrutmannJ.UnfriedK.The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation1802935200910.1164/rccm.200812-1911OC19324973Search in Google Scholar
Sydlik U., Bilstein A.: Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation. Eur. Respir. J. 41, 433–442 (2013)SydlikU.BilsteinA.Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation41433442201310.1183/09031936.0013221123100492Search in Google Scholar
Tanne C., Golovina E.A., Hoekstra F.A., Meffert A., Galinski E.A.: Glass-forming property of hydroxyectoine is the cause of its superior function as a desiccation protectant. Front. Microbiol. 5, 150 (2014)TanneC.GolovinaE.A.HoekstraF.A.MeffertA.GalinskiE.A.Glass-forming property of hydroxyectoine is the cause of its superior function as a desiccation protectant5150201410.3389/fmicb.2014.00150398349124772110Search in Google Scholar
Tao P., Li H., Yu Y., Gu J., Liu Y.: Ectoine and 5-hydroxyectoine accumulation in the halophile Virgibacillus halodenitrificans PDB-F2 in response to salt stress. Appl. Microbiol. Biotechnol. 100, 6779–6789 (2016)TaoP.LiH.YuY.GuJ.LiuY.Ectoine and 5-hydroxyectoine accumulation in the halophile Virgibacillus halodenitrificans PDB-F2 in response to salt stress10067796789201610.1007/s00253-016-7549-x27106915Search in Google Scholar
Trotsenko Y.A., Doronina N.V., Khmelenina V.N.: Biotechnological potential of aerobic methylotrophic bacteria: A review of current state and future prospects. Appl Biochem Microbiol. 41, 433–441 (2005)TrotsenkoY.A.DoroninaN.V.KhmeleninaV.N.Biotechnological potential of aerobic methylotrophic bacteria: A review of current state and future prospects41433441200510.1007/s10438-005-0078-5Search in Google Scholar
Unfried K., Kroker M., Autengruber A., Gotić M., Sydlik U.: The compatible solute ectoine reduces the exacerbating effect of environmental model particles on the immune response of the airways. J. Allergy. 2014, 1–7 (2014)UnfriedK.KrokerM.AutengruberA.GotićM.SydlikU.The compatible solute ectoine reduces the exacerbating effect of environmental model particles on the immune response of the airways201417201410.1155/2014/708458400521824822073Search in Google Scholar
Vreeland R.H., Litchfield C.D., Martin E.L., Elliot E.: Halomonas elongata, a new genus and species of extremely salt-tolerant bacteria. Int. J. Syst. Bacteriol. 30, 485–495 (1980)VreelandR.H.LitchfieldC.D.MartinE.L.ElliotE.Halomonas elongata, a new genus and species of extremely salt-tolerant bacteria30485495198010.1099/00207713-30-2-485Search in Google Scholar
Widderich N., Hopïpner A., Pittelkow M., Heider J., Smits S.H.J., Bremer E.: Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms. PLoS One, 9, e93809 (2014)WidderichN.HopïpnerA.PittelkowM.HeiderJ., Smits S.H.J., BremerE.Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms9e93809201410.1371/journal.pone.0093809397972124714029Search in Google Scholar
Yao C.-L., Lin Y.-M., Mohamed M.S., Chen J.-H.: Inhibitory effect of ectoine on melanogenesis in B16-F0 and A2058 melanoma cell lines. Biochem. Eng. J. 78, 163–169 (2013)YaoC.-L.LinY.-M.MohamedM.S.ChenJ.-H.Inhibitory effect of ectoine on melanogenesis in B16-F0 and A2058 melanoma cell lines78163169201310.1016/j.bej.2013.01.005Search in Google Scholar
Zaccai G., Martel A. et al.: Neutrons describe ectoine effects on water H-bonding and hydration around a soluble protein and a cell membrane. Sci. Rep. 6, 31434 (2016)ZaccaiG.MartelA.Neutrons describe ectoine effects on water H-bonding and hydration around a soluble protein and a cell membrane631434201610.1038/srep31434498563327527336Search in Google Scholar
Zhang L.H., Lang Y.J., Nagata S.: Efficient production of ectoine using ectoine-excreting strain. Extremophiles 13, 717–724 (2009)ZhangL.H.LangY.J.NagataS.Efficient production of ectoine using ectoine-excreting strain13717724200910.1007/s00792-009-0262-219551460Search in Google Scholar
Zhang L., Lang Y., Wang C., Nagata S.: Promoting effect of compatible solute ectoine on the ethanol fermentation by Zymomonas mobilis CICC10232. Process. Biochem. 43, 642–646 (2008)ZhangL.LangY.WangC.NagataS.Promoting effect of compatible solute ectoine on the ethanol fermentation by Zymomonas mobilis CICC1023243642646200810.1016/j.procbio.2008.02.003Search in Google Scholar
Zhang L., Wang Y., Zhang C., Wang Y., Zhu D., Wang C., Nagata S.: Supplementation effect of ectoine on thermostability of phytase. J. Biosci. Bioeng. 102, 560–563 (2006)ZhangL.WangY.ZhangC.WangY.ZhuD.WangC.NagataS.Supplementation effect of ectoine on thermostability of phytase102560563200610.1263/jbb.102.56017270722Search in Google Scholar