<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction:</bold> The main problem in poultry farming is the difficulty in producing food of animal origin without using antibacterial agents. Because most antibacterial compounds are dispensed in water, some water supply systems can be contaminated by antibiotics which are then administered to the animals unintentionally. This can lead to unexpected increases in antibiotic residues in food of animal origin. The aim of the present study was to determine whether the constant exposure of chicken broilers to enrofloxacin affects the withdrawal time of a therapeutic doxycycline that is intentionally administered to the chickens.<bold>Material and Methods:</bold> The concentrations of doxycycline, enrofloxacin, and ciprofloxacin were determined by LC-MS/MS in muscles and liver of the chickens.<bold>Results:</bold> Doxycycline residue concentrations in the chicken tissues from the group that received trace amounts of enrofloxacin were nearly 50% greater than those of the group that received only doxycycline.<bold>Conclusion:</bold> These results indicated that constant exposure to enrofloxacin in trace amounts significantly influences the residual doxycycline concentration in chicken tissues.</abstract>

Introduction: The main problem in poultry farming is the difficulty in producing food of animal origin without using antibacterial agents. Because most antibacterial compounds are dispensed in water, some water supply systems can be contaminated by antibiotics which are then administered to the animals unintentionally. This can lead to unexpected increases in antibiotic residues in food of animal origin. The aim of the present study was to determine whether the constant exposure of chicken broilers to enrofloxacin affects the withdrawal time of a therapeutic doxycycline that is intentionally administered to the chickens.Material and Methods: The concentrations of doxycycline, enrofloxacin, and ciprofloxacin were determined by LC-MS/MS in muscles and liver of the chickens.Results: Doxycycline residue concentrations in the chicken tissues from the group that received trace amounts of enrofloxacin were nearly 50% greater than those of the group that received only doxycycline.Conclusion: These results indicated that constant exposure to enrofloxacin in trace amounts significantly influences the residual doxycycline concentration in chicken tissues.

Effect of doxycycline concentrations in chicken tissues as a consequence of permanent exposure to enrofloxacin traces in drinking water

Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy,

Department of Poultry Diseases, National Veterinary Research Institute, 24-100 Pulawy,

Journal of Veterinary Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Introduction: The main problem in poultry farming is the difficulty in producing food of animal origin without using antibacterial agents. Because most...

Effect of doxycycline concentrations in chicken tissues as a consequence of permanent exposure to enrofloxacin traces in drinking water

Publié en ligne: 23 sept. 2016

Pages: 293 - 299

Reçu: 21 juin 2016

Accepté: 05 sept. 2016

DOI: https://doi.org/10.1515/jvetres-2016-0045

Mots clés
chickens, doxycycline, enrofloxacin, drinking water, LC-MS/MS

© 2016 Małgorzata Gbylik-Sikorska et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Effect of doxycycline concentrations in chicken tissues as a consequence of permanent exposure to enrofloxacin traces in drinking water

Publié en ligne: 23 sept. 2016

Pages: 293 - 299

Reçu: 21 juin 2016

Accepté: 05 sept. 2016

DOI: https://doi.org/10.1515/jvetres-2016-0045

Mots cléschickens, doxycycline, enrofloxacin, drinking water, LC-MS/MS

© 2016 Małgorzata Gbylik-Sikorska et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Mots clés
chickens, doxycycline, enrofloxacin, drinking water, LC-MS/MS