<abstract xmlns="http://www.w3.org/1999/xhtml"><p> In topical formulations, the rheological parameters and pharmaceutical availability of many active agents have been improved by the addition of modern excipients. This translates into increased interest in the topical use of NSAIDs. The aim of this study was to create series of effective oil in water (O/W) diclofenac sodium cream formulations that differ in the applied fatty phase, utilizing Gelot <sup>TM</sup>64 (Gattefosse) (a modern non-ionic emulsifier). In the produced prescriptions, estimation was made of the effect of this on the rheological parameters and the pharmaceutical availability of the diclofenac sodium. Herein, the hydrophilic petrolatum-based cream demonstrated the highest rate of release of the active agent, as well as the best set of beneficial rheological parameters.</p></abstract>

In topical formulations, the rheological parameters and pharmaceutical availability of many active agents have been improved by the addition of modern excipients. This translates into increased interest in the topical use of NSAIDs. The aim of this study was to create series of effective oil in water (O/W) diclofenac sodium cream formulations that differ in the applied fatty phase, utilizing Gelot TM64 (Gattefosse) (a modern non-ionic emulsifier). In the produced prescriptions, estimation was made of the effect of this on the rheological parameters and the pharmaceutical availability of the diclofenac sodium. Herein, the hydrophilic petrolatum-based cream demonstrated the highest rate of release of the active agent, as well as the best set of beneficial rheological parameters.

The use of the Gelot emulsifier in diclofenac sodium semi-solid preparations

Current Issues in Pharmacy and Medical Sciences

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{"article-title":"The use of the Gelot emulsifier in diclofenac sodium semi-solid preparations"}

In topical formulations, the rheological parameters and pharmaceutical availability of many active agents have been improved by the addition of modern...

The use of the Gelot emulsifier in diclofenac sodium semi-solid preparations

Publié en ligne: 23 juin 2017

Pages: 43 - 49

Reçu: 14 mars 2017

Accepté: 09 mai 2017

DOI: https://doi.org/10.1515/cipms-2017-0010

Mots clés
diclofenac sodium, emulsifiers, rheology, pharmaceutical availability

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

The use of the Gelot emulsifier in diclofenac sodium semi-solid preparations

Publié en ligne: 23 juin 2017

Pages: 43 - 49

Reçu: 14 mars 2017

Accepté: 09 mai 2017

DOI: https://doi.org/10.1515/cipms-2017-0010

Mots clésdiclofenac sodium, emulsifiers, rheology, pharmaceutical availability

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Mots clés
diclofenac sodium, emulsifiers, rheology, pharmaceutical availability