Acetyl-CoA Carboxylase α and Stearoyl-CoA Desaturase Genes Polymorphism and their Influence on Fatty Acid Profile in Milk of Polish Holstein-Friesian Cows

Artegoitia V., Meikle A., Olazabal L., Damián J.P., Adrien M.L., Mattiauda D.A., Bermudez J., Torre A., Carriquiry M. (2013). Milk casein and fatty acid fractions in early lactation are affected by nutritional regulation of body condition score at the beginning of the transition period in primiparous and multiparous cows under grazing conditions. J. Anim. Physiol. Anim. Nutr., 97: 919–932.Search in Google Scholar

Barber M.C., Price N.T., Travers M.T. (2005). Structure and regulation of acetyl-CoA carboxylase gene of metazoa. Biochim. Biophys. Acta, 1733: 1–28.Search in Google Scholar

Bernard L., Leroux C., Hayes H., Gautier M., Chilliard Y., Martin P. (2001). Characterization of the caprine stearoyl-CoA desaturase gene and its mRNA showing an unusually long 3′-UTR sequence arising from a single exon. Gene, 281: 53–61.Search in Google Scholar

Bouwman A.C., Bovenhuis H., Visker M.H., van Arendonk J.A., (2011). Genome-wide association of milk fatty acids in Dutch dairy cattle. BMC Genet., 12: 43.Search in Google Scholar

Conte G., Mele M., Chessa S., Castiglioni B., Serra A., Pagnacco G., Secchiari P. (2010). Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle. J. Dairy Sci., 93: 753–763.Search in Google Scholar

Duchemin S., Bovenhuis H., Stoop W.M., Bouwman A.C., van Arendonk J.A.M., Visker M.H.P.W. (2013). Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions. J. Dairy Sci., 96: 592–604.Search in Google Scholar

Folch J., Lees M., Sloane S.G.H. (1957). A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226: 497–509.Search in Google Scholar

Hames D.B., Hooper N.M. (2012). Instant notes in Biochemistry (in Polish). Wyd. Nauk. PWN, 3rd ed., pp. 391–397.Search in Google Scholar

Heck J.M.L. (2009). Milk genomics, opportunities to improve the protein and fatty acid composition in raw milk. PhD thesis, Wageningen University, The Netherlands.Search in Google Scholar

Kaneda M., Lin B.Z., Sasazaki S., Oyama K., Mannen H. (2011). Allele frequencies of gene polymorphisms related to economic traits in Bos taurus and Bos indicus cattle breeds. Anim. Sci. J., 82: 717–721.Search in Google Scholar

Kęsek M., Szulc T., Zielak-Steciwko A. (2014). Genetic, physiological and nutritive factors affecting the fatty acid profile in cows’ milk – a review. Anim. Sci. Pap. Rep., 32: 95–105.Search in Google Scholar

Kgwatalala P.M., Ibeagha-Awemu E.M., Mustafa A.F., Zhao X. (2009). Influence of stearoyl-coenzyme A desaturase 1 genotype and stage of lactation on fatty acid composition of Canadian Jersey cows. J. Dairy Sci., 92: 1220–1228.Search in Google Scholar

Lengi A.J., Corl B.A. (2007). Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5. Lipids, 42: 499–508.10.1007/s11745-007-3056-2Open DOISearch in Google Scholar

Mao J., Arcos S., Davis S.K., Burzlaff J., Seyfert H.M. (2001). Genomic distribution of three promoters of the bovine gene encoding acetyl-CoA carboxylase α and evidence that the nutritionally regulated promoter I contains a repressive element different from that in rat. Biochem. J., 358: 127–135.Search in Google Scholar

Mao J., Seyfert H.M. (2002). Promoter II of the bovine acetylcoenzyme A carboxylase-alpha-encoding gene is widely expressed and strongly active in different cells. Biochim. Biophys. Acta, 1576: 324–329.10.1016/S0167-4781(02)00369-XOpen DOISearch in Google Scholar

Mao J., Molenaar A.J., Wheeler T.T., Seyfert H.M. (2002). STAT5 binding contributes to lactational stimulation of promoter III expressing the bovine acetyl-CoA carboxylase alpha-encoding gene in the mammary gland. J. Mol. Endocrinol., 29: 73–88.Search in Google Scholar

Matsuhashi T., Maruyama S., Uemoto Y., Kobayashi N., Mannen H., Abe T., Sa-kaguchi S., Kobayashi E. (2011). Effects of bovine fatty acid synthase, stearoyl-coenzyme A desaturase, sterol regulatory element-binding protein 1, and growth hormone gene polymorphisms on fatty acid composition and carcass traits in Japanese Black cattle. J. Anim. Sci., 89: 12–22.Search in Google Scholar

Matsumoto H., Sasaki K., Bessho T., Kobayashi E., Abe T., Sasazaki S., Oya-ma K., Mannen H. (2012). The SNPs in ACACA gene are effective on fatty acid composition in Holstein milk. Mol. Biol. Rep., 39: 8637–8644.Search in Google Scholar

Moioli B., Contarini G., Avalli A., Catillo G., Orru L., De Matteis G., Masoero G., Napolitano F. (2007). Short communication: effect of stearoyl-coenzyme A desaturase polymorphism on fatty acid composition of milk. J. Dairy Sci., 90: 3553–3558.10.3168/jds.2006-85517582140Open DOISearch in Google Scholar

Moioli B., Scata M.C., De Matteis G., Annicchiarico G., Catillo G., Napolitano F. (2013). The ACACA gene is a potential candidate gene for fat content in sheep milk. Anim. Genet., 44: 601–603.Search in Google Scholar

Nałęcz-Tarwacka T., Kuczyńska B., Grodzki H., Slósarz J. (2009). Effect of selected factors on conjugated linoleic acid content in milk of dairy cows. Med. Weter., 65: 326–329.Search in Google Scholar

National Centerfor Biotechnology Information. Open Reading Frame Finder (ORF Finder). Available from: www.ncbi.nlm.nih.gov/gorf/gorfSearch in Google Scholar

Pereira S.L., Leonard A.E., Mukerji P. (2003). Recent advances in the study of fatty acid desaturases from animals and lower eukaryotes. Prostag. Leukotr. Ess., 68: 97–106.Search in Google Scholar

RCore Team (2016). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/.Search in Google Scholar

Schennink A., Heck J.M., Bovenhuis H., Visker M.H.P.W., van Valenberg H.J.F., van Arendonk J.A.M. (2008). Milk fatty acid unsaturation: genetic parameters and effects of stearoyl-CoA desaturase (SCD1) and acyl-CoA: diacylglycerol acylotransferase (DGAT1). J. Dairy Sci., 91: 2135–2143.Search in Google Scholar

Shanklin J., Whittle E., Fox B.G. (1994). Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stearoyl-CoA desaturase, and are conserved in alkane hydroxylase and xylene monooxygenase. Biochemistry, 33: 12787–12794.10.1021/bi00209a0097947684Open DOISearch in Google Scholar

Shingfield K.J., Bernard L., Leroux C., Chilliard Y. (2010). Role of trans fatty acids in the nutritional regulation of mammary lipogenesis in ruminants. Animal, 4: 1140–1166.10.1017/S175173111000051022444614Open DOISearch in Google Scholar

Signorelli F., Napolitano F., de Matteis G., Scata M.C., Catillo G., Tripaldi C., Moioli B. (2009 a). Identification of novel single nucleotide polymorphisms in promoter III of the acetyl-CoA carboxylase-α gene in goats affecting milk production traits. J. Hered., 100: 386–389.10.1093/jhered/esn09818990725Search in Google Scholar

Signorelli F., Orrù L., Napolitano F., De Matteis G., Scatà M.C., Catillo G., Marchitelli C., Moioli B. (2009 b). Exploring polymorphisms and effects on milk traits of the DGAT1, SCD1 and GHR genes in four cattle breeds. Livest Sci., 125: 74–79.10.1016/j.livsci.2009.02.014Search in Google Scholar

Stoop W.M., Bovenhuis H., Heck J.M.L., van Arendonk J.A.M. (2009). Effect of lactation stage and energy status on milk fat composition of Holstein-Friesian cows. J. Dairy Sci., 92: 1469–1478.10.3168/jds.2008-146819307628Open DOISearch in Google Scholar

Untergasser A., Nijveen H., Rao X., Bisseling T., Geurts R., Leunissen J.A.M. (2007). Primer3Plus, an enhanced web interface to Primer3. Nucleic Acids Res., 35: W71–W74.10.1093/nar/gkm306193313317485472Open DOISearch in Google Scholar

Vincze T., Posfai J., Roberts R.J. (2003). NEBcutter: a program to cleave DNA with restriction enzymes. Nucleic Acids Res., 31: 3688–3691.10.1093/nar/gkg52616893312824395Open DOISearch in Google Scholar

Zhang S., Knight T.J., Reecy J.M., Wheeler T.L., Shackelford S.D., Cundiff L.V., Beitz D.C. (2009). Association of polymorphisms in the promoter I of bovine acetyl-CoA carboxylase-α gene with beef fatty acid composition. Anim. Genet., 41: 417–420.Search in Google Scholar