<abstract xmlns="http://www.w3.org/1999/xhtml"> Objective. The aim of this study was to evaluate serum levels of the biochemical markers of bone metabolism: osteocalcin (OC), beta-carboxyterminal cross-linked telopeptide of type I collagen (β-CTx) with the presence of bone metastases detected by whole-body bone scintigraphy in patients with malignant melanoma. Methods. We determined the markers of bone metabolism in the serum by electrochemiluminescent immunoanalysis in 14 patients with melanoma and in 10 persons without malignant disease (control subjects). All participants were examined by whole-body bone scintigraphy using hybrid scanner of type BrightView XCT. Results. The bone metastases by whole-body bone scintigraphy were in 5 cases, probably in 3 cases and 6 patients were without bone metastases from 14 patients (4 men, 10 women). The concentration of OC in patients was lower about 25.4% in comparison with control subjects. The concentration of OC in the serum was below physiological value in 6 patients and in 4 cases with bone metastases. The concentration of β-CTx was below physiological value in 3 patients and in 2 cases with bone metastases. Conclusion. We observed lower concentration of osteocalcin in patients with malignant melanoma compared to control subjects and the lowest ostecalcin concentration was observed in patients with bone metastases. We did not observe changes in the concentration of beta-carboxyterminal cross-linked telopeptide of type I collagen compared neither to control subjects nor between patients with or without bone metastases.</abstract>

Department of Nuclear Medicine, Hospital Poprad, Banicka 803/28, 058 45 Poprad, Slovak Republic

Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Department of Medical Biochemistry, Mala Hora 4, 036 01 Martin, Slovak Republic

Comparison of the Whole-Body Bone Scintigraphy with Levels of the Markers of Bone Metabolism in Serum of Patients with Malignant Melanoma

<abstract xmlns="http://www.w3.org/1999/xhtml">Background: Roflumilast as a phosphodiesterase 4 inhibitor has shown to increase lung functions and decrease the number of exacerbations in chronic obstructive lung disease. In this study, its ability to decrease the airway hyperresponsiveness in a model of eosinophil inflammation was evaluated. Methods: Healthy adult male guinea pigs were divided into groups as follows: the first group was considered as a healthy control group (without sensitization and therapy), animals in the second group were sensitized with ovalbumin, but left without further treatment, and the animals in the third group were sensitized with ovalbumin and treated with roflumilast perorally for 7 consecutive days. In vivo airway reactivity was evaluated using double-chamber whole body plethysmograph and measuring the specific airway resistance after nebulization of histamine aerosol. In vitro experiments were performed with tissue strips of trachea and lungs in organ bath, where their contractile responses to cumulative doses of acetylcholine and histamine were registered. The numbers of inflammatory cells in blood and bronchoalveolar lavage fluid were measured using standard staining. Results: Guinea pigs with roflumilast treatment showed decreased in vivo and in vitro airway reactivity associated with suppressed recruitment of inflammatory cells (especially eosinophils) in blood and bronchoalveolar lavage fluid. Conclusion: Roflumilast has demonstrated the therapeutic potential in the model of ovalbumin induced eosinophil inflammation typically present in patients with bronchial asthma.</abstract>

Department of Pharmacology, Comenius University, Jessenius School of Medicine, Sklabinska 26, 036 01 Martin, Slovakia

Department of Physiology, Jessenius School of Medicine, Martin, Comenius University and BioMed, Martin, Slovakia

Effects of Roflumilast, Selective PDE4 Inhibitor, on Airway Reactivity in Ovalbumin-Sensitized Guinea Pigs

<abstract xmlns="http://www.w3.org/1999/xhtml"> Objective: ADHD (Attention deficit/hyperactivity disorder) is the most common diagnosed neurobehavioral disorder in childhood and adolescence. Core symptoms of ADHD are persistent inattention, hyperactivity and impulsivity. In Slovakia, there are two specific medication choices to treat ADHD - atomoxetine and methylphenidate. Even though methylphenidate is option number one according to guidelines, the highest amount of patients are taking atomoxetine.Aim: Our aim was to observe atomoxetine and methylphenidate effect in 40 child and adolescent patients with ADHD to compare their efficacy in child and adolescent patients using ADHD-RS-IV scale and CGI scale. Methods: We included 40- hospitalised patients, 20 patients were taking atomoxetine and 20 patients methylphenidate. Therapeutic effect on symptoms of inattention, hyperactivity/impulsivity and global score was measured by ADHD-rating scale IV. Global clinical condition of patients was evaluated by CGI (Clinical Global Impression Scale). Symptomatology was measured before treatment, and every 2 weeks during 8 weeks of treatment. CGI was administrated before and after treatment. Results: We found significant therapeutic effect of atomoxetine and methylphenidate on core symptoms of ADHD after 8 weeks of treatment both with atomoxetine and methylphenidate. We found non-significant difference CGI scale scores. Conclusion: Our study evaluated atomoxetine and methylphenidate treatment effect on ADHD. Atomoxetine and methylphenidate showed significant effect on core symptoms of ADHD, there were no significant between group differences in ADHD-RS-IV. Our study revealed non-significant difference CGI scale scores between medication groups.</abstract>

Department of Pharmacology Comenius University Bratislava, Jessenius Faculty of Medicine Martin, Slovakia

Clinic of Psychiatry, Comenius University Bratislava, Jessenius Faculty of Medicine Martin and University Hospital in Martin, Slovakia

Atomoxetine and Methylphenidate Treatment in ADHD

<abstract xmlns="http://www.w3.org/1999/xhtml"> Amplitude-integrated electroencephalography (aEEG) is a simplified bedside neurophysiology tool that has become widely used in neonates in the last few years. Although aEEG cannot replace conventional EEG (cEEG) for background monitoring and detection of seizures, it remains a useful apparatus that complements conventional EEG, is being widely adopted by neonatologists, and should be supported by neonatal neurologists. Limited channel leads are applied to the patient and data are displayed in a semilogarithmic, time-compressed scale. In term neonates, aEEG has been used to determine the prognosis and treatment for those affected by hypoxic-ischemic encephalopathy, seizures, meningitis and even congenital heart disease. In preterm infants, normative values and pattern corresponding to gestational age are being established. The senzitivity and specificity of aEEG are enhanced by the display of a simultaneous raw EEG.</abstract>

Amplitude-Integrated Electroencephalography: Classification and Possibilities of Use in Practice

<abstract xmlns="http://www.w3.org/1999/xhtml"> Effective public health risk communication plays an important role in various crisis situations such as natural disasters and catastrophes, accidents, terrorist attacks, epidemics or pandemics, and significantly helps to minimise their negative impacts on health of the public. In our work we focused on communication of the health sector authorities with the public during the A(H1N1) pandemic in 2009-2010. We retrospectively analysed the effectiveness of the information leaflet Personal measures during pandemic flu A(H1N1) issued by the Ministry of Health of the Slovak Republic and discovered statistically significant differences in attitudes of various groups of respondents (differing in age and academic background) to design, comprehensibility, and contents of the leaflet, as well as shortcomings in its accessibility and distribution. For preparation of future information materials aimed at epidemics, pandemics and/or other possible crisis situations in Slovakia it is highly recommended to take into consideration specificities and needs of particular target groups of population, ensure effective distribution of information materials, and pay better attention to preparation of the information campaign as the whole.</abstract>

Department of Public Health, Jessenius Faculty of Medicine, Sklabinska 26, 036 01 Martin, Slovak Republic

Department of Medical Biology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovak Republic

Effectiveness of the Information Leaflet Personal Measures During Pandemic Flu A(H1N1) Issued by the Ministry of Health of the Slovak Republic During the 2009/2010 Flu Pandemic

AHEAD OF PRINT

Volume 24 (2024): Issue 1 (April 2024)

Volume 23 (2023): Issue 3 (December 2023)

Volume 23 (2023): Issue 2 (August 2023)

Volume 23 (2023): Issue 1 (April 2023)

Volume 22 (2022): Issue 3 (December 2022)

Volume 22 (2022): Issue 2 (August 2022)

Volume 22 (2022): Issue 1 (April 2022)

Volume 21 (2021): Issue 3 (December 2021)

Volume 21 (2021): Issue 2 (August 2021)

Volume 21 (2021): Issue 1 (March 2021)

Volume 20 (2020): Issue 3 (December 2020)

Volume 20 (2020): Issue 2 (August 2020)

Volume 20 (2020): Issue 1 (April 2020)

Volume 19 (2019): Issue 3 (December 2019)

Volume 19 (2019): Issue 2 (August 2019)

Volume 19 (2019): Issue 1 (April 2019)

Volume 18 (2018): Issue 3 (December 2018)

Volume 18 (2018): Issue 2 (August 2018)

Volume 18 (2018): Issue 1 (June 2018)

Volume 17 (2017): Issue 3 (December 2017)

Volume 17 (2017): Issue 2 (August 2017)

Volume 17 (2017): Issue 1 (April 2017)

Volume 16 (2016): Issue 3 (December 2016)

Volume 16 (2016): Issue 2 (August 2016)

Volume 16 (2016): Issue 1 (April 2016)

Volume 15 (2015): Issue 3 (December 2015)

Volume 15 (2015): Issue 2 (September 2015)

Volume 15 (2015): Issue 1 (May 2015)

Volume 14 (2014): Issue 2 (September 2014)

Volume 14 (2014): Issue 1 (May 2014)

Volume 13 (2014): Issue 3 (February 2014)

Volume 13 (2013): Issue 2 (November 2013)

Volume 13 (2013): Issue 1 (March 2013)

Volume 13 (2013): Issue Supplement-1 (March 2013)

Volume 12 (2012): Issue Supplement-1 (February 2012)

Volume 12 (2012): Issue 3 (December 2012)

Volume 12 (2012): Issue 2 (August 2012)

Volume 12 (2012): Issue 1 (March 2012)

Volume 11 (2011): Issue Supplement-1 (March 2011)

Volume 11 (2011): Issue 3 (December 2011)

Volume 11 (2011): Issue 2 (August 2011)

Volume 11 (2011): Issue 1 (March 2011)

Acta Medica Martiniana

 Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. The aims and scope of the AMM:   Dissemination of research results and scientific knowledge from all areas of medicine and nursing.  Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome.   Acta Medica Martiniana (AMM) publishes, and here only in English, high quality original papers (in extenso and short-rapid communications), case reports as well as review articles.  Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.  All articles are submitted to a peer-review process. They are peer-reviewed anonymously (double blind) by external experts pursuant to the standard evaluation criteria. Based on the reviewers opinions, the Editorial Board will decide whether a paper is to be included in the journal.  Rejection Rate:   15-30%   Archiving  Sciendo archives the contents of this journal in Portico - digital long-term preservation service of scholarly books, journals and collections.  Plagiarism Policy  The editorial board is participating in a growing community of Similarity Check System's users in order to ensure that the content published is original and trustworthy. Similarity Check is a medium that allows for comprehensive manuscripts screening, aimed to eliminate plagiarism and provide a high standard and quality peer-review process. 