Probiotics and Prebiotics as Dietary Supplements for the Adjunctive Treatment of Type 2 Diabetes

AL-Dulaimi M, Algburi A, Abdelhameed A, Mazanko MS, Rudoy DV, Ermakov AM, Chikindas ML. Antimicrobial and anti-biofilm activity of polymyxin E alone and in combination with probiotic strains of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 against clinical isolates of selected Acinetobacter spp.: a preliminary study. Pathogens. 2021 Dec;10(12):1574. https://doi.org/10.3390/pathogens10121574 AL-Dulaimi M Algburi A Abdelhameed A Mazanko MS Rudoy DV Ermakov AM Chikindas ML . Antimicrobial and anti-biofilm activity of polymyxin E alone and in combination with probiotic strains of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 against clinical isolates of selected Acinetobacter spp.: a preliminary study . Pathogens. 2021 Dec ; 10 ( 12 ): 1574 . https://doi.org/10.3390/pathogens10121574 Search in Google Scholar

Balaich J, Estrella M, Wu G, Jeffrey PD, Biswas A, Zhao L, Korennykh A, Donia MS. The human microbiome encodes resistance to the antidiabetic drug acarbose. Nature. 2021 Dec; 600(7887): 110–115. https://doi.org/10.1038/s41586-021-04091-0 Balaich J Estrella M Wu G Jeffrey PD Biswas A Zhao L Korennykh A Donia MS . The human microbiome encodes resistance to the antidiabetic drug acarbose . Nature. 2021 Dec ; 600 ( 7887 ): 110 – 115 . https://doi.org/10.1038/s41586-021-04091-0 Search in Google Scholar

Bock PM, Telo GH, Ramalho R, Sbaraini M, Leivas G, Martins AF, Schaan BD. The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta-analysis. Diabetologia. 2021 Jan;64(1):26–41. https://doi.org/10.1007/s00125-020-05295-1 Bock PM Telo GH Ramalho R Sbaraini M Leivas G Martins AF Schaan BD . The effect of probiotics, prebiotics or synbiotics on metabolic outcomes in individuals with diabetes: a systematic review and meta-analysis . Diabetologia. 2021 Jan ; 64 ( 1 ): 26 – 41 . https://doi.org/10.1007/s00125-020-05295-1 Search in Google Scholar

Buse JB, DeFronzo RA, Rosenstock J, Kim T, Burns C, Skare S, Baron A, Fineman M. The primary glucose-lowering effect of metformin resides in the gut, not the circulation: results from short-term pharmacokinetic and 12-week dose-ranging studies. Diabetes Care. 2016 Feb;39(2):198–205. https://doi.org/10.2337/dc15-0488 Buse JB DeFronzo RA Rosenstock J Kim T Burns C Skare S Baron A Fineman M . The primary glucose-lowering effect of metformin resides in the gut, not the circulation: results from short-term pharmacokinetic and 12-week dose-ranging studies . Diabetes Care. 2016 Feb ; 39 ( 2 ): 198 – 205 . https://doi.org/10.2337/dc15-0488 Search in Google Scholar

Canfora EE, Meex RCR, Venema K, Blaak EE. Gut microbial metabolites in obesity, NAFLD and T2DM. Nat Rev Endocrinol. 2019 May;15(5):261–273. https://doi.org/10.1038/s41574-019-0156-z Canfora EE Meex RCR Venema K Blaak EE . Gut microbial metabolites in obesity, NAFLD and T2DM . Nat Rev Endocrinol. 2019 May ; 15 ( 5 ): 261 – 273 . https://doi.org/10.1038/s41574-019-0156-z Search in Google Scholar

de Cossío LF, Fourrier C, Sauvant J, Everard A, Capuron L, Cani PD, Layé S, Castanon N. Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome. Brain Behav Immun. 2017 Aug;64:33–49. https://doi.org/10.1016/j.bbi.2016.12.022 de Cossío LF Fourrier C Sauvant J Everard A Capuron L Cani PD Layé S Castanon N . Impact of prebiotics on metabolic and behavioral alterations in a mouse model of metabolic syndrome . Brain Behav Immun. 2017 Aug ; 64 : 33 – 49 . https://doi.org/10.1016/j.bbi.2016.12.022 Search in Google Scholar

Dey S, Blanch-Asensio M, Balaji Kuttae S, Sankaran S. Novel genetic modules encoding high-level antibiotic-free protein expression in probiotic lactobacilli. Microb Biotechnol. 2023 Feb; 1751–7915.14228. https://doi.org/10.1111/1751-7915.14228 Dey S Blanch-Asensio M Balaji Kuttae S Sankaran S . Novel genetic modules encoding high-level antibiotic-free protein expression in probiotic lactobacilli . Microb Biotechnol. 2023 Feb ; 1751 – 7915 .14228. https://doi.org/10.1111/1751-7915.14228 Search in Google Scholar

Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci USA. 2013 May;110(22):9066–9071. https://doi.org/10.1073/pnas.1219451110 Everard A Belzer C Geurts L Ouwerkerk JP Druart C Bindels LB Guiot Y Derrien M Muccioli GG Delzenne NM Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity . Proc Natl Acad Sci USA. 2013 May ; 110 ( 22 ): 9066 – 9071 . https://doi.org/10.1073/pnas.1219451110 Search in Google Scholar

Fernandez MA, Marette A. Potential health benefits of combining yogurt and fruits based on their probiotic and prebiotic properties. Adv Nutr. 2017 Jan;8(1):155S–164S. https://doi.org/10.3945/an.115.011114 Fernandez MA Marette A . Potential health benefits of combining yogurt and fruits based on their probiotic and prebiotic properties . Adv Nutr. 2017 Jan ; 8 ( 1 ): 155S – 164S . https://doi.org/10.3945/an.115.011114 Search in Google Scholar

Gao M, Jebb SA, Aveyard P, Ambrosini GL, Perez-Cornago A, Papier K, Carter J, Piernas C. Associations between dietary patterns and incident type 2 diabetes: prospective cohort study of 120,343 UK Biobank participants. Diabetes Care. 2022 Jun;45(6):1315–1325. https://doi.org/10.2337/dc21-2258 Gao M Jebb SA Aveyard P Ambrosini GL Perez-Cornago A Papier K Carter J Piernas C . Associations between dietary patterns and incident type 2 diabetes: prospective cohort study of 120,343 UK Biobank participants . Diabetes Care. 2022 Jun ; 45 ( 6 ): 1315 – 1325 . https://doi.org/10.2337/dc21-2258 Search in Google Scholar

Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, et al. Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017 Aug;14(8):491–502. https://doi.org/10.1038/nrgastro.2017.75 Gibson GR Hutkins R Sanders ME Prescott SL Reimer RA Salminen SJ Scott K Stanton C Swanson KS Cani PD Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics . Nat Rev Gastroenterol Hepatol. 2017 Aug ; 14 ( 8 ): 491 – 502 . https://doi.org/10.1038/nrgastro.2017.75 Search in Google Scholar

Gordon B, Ridinger S, Krick R, Grosvenor L, Charron R. Fruit and vegetable prescription program for diabetes control among community health centers in Rural Idaho and Oregon. Am J Public Health. 2022 Jul;112(7):975–979. https://doi.org/10.2105/AJPH.2022.306853 Gordon B Ridinger S Krick R Grosvenor L Charron R . Fruit and vegetable prescription program for diabetes control among community health centers in Rural Idaho and Oregon . Am J Public Health. 2022 Jul ; 112 ( 7 ): 975 – 979 . https://doi.org/10.2105/AJPH.2022.306853 Search in Google Scholar

Guo Q, Goldenberg JZ, Humphrey C, El Dib R, Johnston BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2019 Apr;4(4):CD004827. https://doi.org/10.1002/14651858.CD004827.pub5 Guo Q Goldenberg JZ Humphrey C El Dib R Johnston BC . Probiotics for the prevention of pediatric antibiotic-associated diarrhea . Cochrane Database Syst Rev. 2019 Apr ; 4 ( 4 ): CD004827 . https://doi.org/10.1002/14651858.CD004827.pub5 Search in Google Scholar

Healey G, Brough L, Butts C, Murphy R, Whelan K, Coad J. Influence of habitual dietary fibre intake on the responsiveness of the gut microbiota to a prebiotic: protocol for a randomised, double-blind, placebo-controlled, cross-over, single-centre study. BMJ Open. 2016 Sep;6(9):e012504. https://doi.org/10.1136/bmjopen-2016-012504 Healey G Brough L Butts C Murphy R Whelan K Coad J . Influence of habitual dietary fibre intake on the responsiveness of the gut microbiota to a prebiotic: protocol for a randomised, double-blind, placebo-controlled, cross-over, single-centre study . BMJ Open. 2016 Sep ; 6 ( 9 ): e012504 . https://doi.org/10.1136/bmjopen-2016-012504 Search in Google Scholar

Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, et al. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506–514. https://doi.org/10.1038/nrgastro.2014.66 Hill C Guarner F Reid G Gibson GR Merenstein DJ Pot B Morelli L Canani RB Flint HJ Salminen S The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic . Nat Rev Gastroenterol Hepatol. 2014 Aug ; 11 ( 8 ): 506 – 514 . https://doi.org/10.1038/nrgastro.2014.66 Search in Google Scholar

Holman N, Young B, Gadsby R. Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK. Diabet Med. 2015 Sep;32(9):1119–1120. https://doi.org/10.1111/dme.12791 Holman N Young B Gadsby R . Current prevalence of Type 1 and Type 2 diabetes in adults and children in the UK . Diabet Med. 2015 Sep ; 32 ( 9 ): 1119 – 1120 . https://doi.org/10.1111/dme.12791 Search in Google Scholar

Holt S, Carter DC, Tothill P, Heading RC, Prescott LF. Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet. 1979 Mar;313(8117):636–639. https://doi.org/10.1016/S0140-6736(79)91079-1 Holt S Carter DC Tothill P Heading RC Prescott LF . Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol . Lancet. 1979 Mar ; 313 ( 8117 ): 636 – 639 . https://doi.org/10.1016/S0140-6736(79)91079-1 Search in Google Scholar

Hosomi K, Saito M, Park J, Murakami H, Shibata N, Ando M, Nagatake T, Konishi K, Ohno H, Tanisawa K, et al. Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota. Nat Commun. 2022 Aug;13(1):4477. https://doi.org/10.1038/s41467-022-32015-7 Hosomi K Saito M Park J Murakami H Shibata N Ando M Nagatake T Konishi K Ohno H Tanisawa K Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota . Nat Commun. 2022 Aug ; 13 ( 1 ): 4477 . https://doi.org/10.1038/s41467-022-32015-7 Search in Google Scholar

Kanazawa A, Aida M, Yoshida Y, Kaga H, Katahira T, Suzuki L, Tamaki S, Sato J, Goto H, Azuma K, et al. Effects of synbiotic supplementation on chronic inflammation and the gut microbiota in obese patients with type 2 diabetes mellitus: A randomized controlled study. Nutrients. 2021 Feb;13(2):558. https://doi.org/10.3390/nu13020558 Kanazawa A Aida M Yoshida Y Kaga H Katahira T Suzuki L Tamaki S Sato J Goto H Azuma K Effects of synbiotic supplementation on chronic inflammation and the gut microbiota in obese patients with type 2 diabetes mellitus: A randomized controlled study . Nutrients. 2021 Feb ; 13 ( 2 ): 558 . https://doi.org/10.3390/nu13020558 Search in Google Scholar

Kesika P, Sivamaruthi BS, Chaiyasut C. Do probiotics improve the health status of individuals with diabetes mellitus? A review on outcomes of clinical trials. BioMed Res Int. 2019 Dec;2019:1–11. https://doi.org/10.1155/2019/1531567 Kesika P Sivamaruthi BS Chaiyasut C . Do probiotics improve the health status of individuals with diabetes mellitus? A review on outcomes of clinical trials . BioMed Res Int. 2019 Dec ; 2019 : 1 – 11 . https://doi.org/10.1155/2019/1531567 Search in Google Scholar

Kocsis T, Molnár B, Németh D, Hegyi P, Szakács Z, Bálint A, Garami A, Soós A, Márta K, Solymár M. Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: a meta-analysis of randomized clinical trials. Sci Rep. 2020 Jul;10(1):11787. https://doi.org/10.1038/s41598-020-68440-1 Kocsis T Molnár B Németh D Hegyi P Szakács Z Bálint A Garami A Soós A Márta K Solymár M . Probiotics have beneficial metabolic effects in patients with type 2 diabetes mellitus: a meta-analysis of randomized clinical trials . Sci Rep. 2020 Jul ; 10 ( 1 ): 11787 . https://doi.org/10.1038/s41598-020-68440-1 Search in Google Scholar

Kumar V, Sinha AK, Makkar HPS, de Boeck G, Becker K. Dietary roles of non-starch polysaccharides in human nutrition: a review. Crit Rev Food Sci Nutr. 2012 Oct;52(10):899–935. https://doi.org/10.1080/10408398.2010.512671 Kumar V Sinha AK Makkar HPS de Boeck G Becker K . Dietary roles of non-starch polysaccharides in human nutrition: a review . Crit Rev Food Sci Nutr. 2012 Oct ; 52 ( 10 ): 899 – 935 . https://doi.org/10.1080/10408398.2010.512671 Search in Google Scholar

Lee SH, Moore LV, Park S, Harris DM, Blanck HM. Adults meeting fruit and vegetable intake recommendations – United States, 2019. MMWR Morb Mortal Wkly Rep. 2022 Jan;71(1):1–9. https://doi.org/10.15585/mmwr.mm7101a1 Lee SH Moore LV Park S Harris DM Blanck HM . Adults meeting fruit and vegetable intake recommendations – United States, 2019 . MMWR Morb Mortal Wkly Rep. 2022 Jan ; 71 ( 1 ): 1 – 9 . https://doi.org/10.15585/mmwr.mm7101a1 Search in Google Scholar

Li Q, Hu J, Nie Q, Chang X, Fang Q, Xie J, Li H, Nie S. Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration. Sci China Life Sci. 2021 Jan;64(1):117–132. https://doi.org/10.1007/s11427-019-1647-6 Li Q Hu J Nie Q Chang X Fang Q Xie J Li H Nie S . Hypoglycemic mechanism of polysaccharide from Cyclocarya paliurus leaves in type 2 diabetic rats by gut microbiota and host metabolism alteration . Sci China Life Sci. 2021 Jan ; 64 ( 1 ): 117 – 132 . https://doi.org/10.1007/s11427-019-1647-6 Search in Google Scholar

Liu W, Luo X, Tang J, Mo Q, Zhong H, Zhang H, Feng F. A bridge for short-chain fatty acids to affect inflammatory bowel disease, type 1 diabetes, and non-alcoholic fatty liver disease positively: by changing gut barrier. Eur J Nutr. 2021 Aug;60(5):2317–2330. https://doi.org/10.1007/s00394-020-02431-w Liu W Luo X Tang J Mo Q Zhong H Zhang H Feng F . A bridge for short-chain fatty acids to affect inflammatory bowel disease, type 1 diabetes, and non-alcoholic fatty liver disease positively: by changing gut barrier . Eur J Nutr. 2021 Aug ; 60 ( 5 ): 2317 – 2330 . https://doi.org/10.1007/s00394-020-02431-w Search in Google Scholar

Madjd A, Taylor MA, Mousavi N, Delavari A, Malekzadeh R, Macdonald IA, Farshchi HR. Comparison of the effect of daily consumption of probiotic compared with low-fat conventional yogurt on weight loss in healthy obese women following an energy-restricted diet: a randomized controlled trial. Am J Clin Nutr. 2016 Feb;103(2):323–329. https://doi.org/10.3945/ajcn.115.120170 Madjd A Taylor MA Mousavi N Delavari A Malekzadeh R Macdonald IA Farshchi HR . Comparison of the effect of daily consumption of probiotic compared with low-fat conventional yogurt on weight loss in healthy obese women following an energy-restricted diet: a randomized controlled trial . Am J Clin Nutr. 2016 Feb ; 103 ( 2 ): 323 – 329 . https://doi.org/10.3945/ajcn.115.120170 Search in Google Scholar

Magliano DJ, Islam RM, Barr ELM, Gregg EW, Pavkov ME, Harding JL, Tabesh M, Koye DN, Shaw JE. Trends in incidence of total or type 2 diabetes: systematic review. BMJ. 2019 Sep;366:l5003. https://doi.org/10.1136/bmj.l5003 Magliano DJ Islam RM Barr ELM Gregg EW Pavkov ME Harding JL Tabesh M Koye DN Shaw JE . Trends in incidence of total or type 2 diabetes: systematic review . BMJ. 2019 Sep ; 366 : l5003 . https://doi.org/10.1136/bmj.l5003 Search in Google Scholar

Matheus VA, Monteiro LCS, Oliveira RB, Maschio DA, Collares-Buzato CB. Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice. Exp Biol Med. 2017 Jun; 242(12): 1214–1226. https://doi.org/10.1177/1535370217708188 Matheus VA Monteiro LCS Oliveira RB Maschio DA Collares-Buzato CB . Butyrate reduces high-fat diet-induced metabolic alterations, hepatic steatosis and pancreatic beta cell and intestinal barrier dysfunctions in prediabetic mice . Exp Biol Med. 2017 Jun ; 242 ( 12 ): 1214 – 1226 . https://doi.org/10.1177/1535370217708188 Search in Google Scholar

Merino J. Precision nutrition in diabetes: when population-based dietary advice gets personal. Diabetologia. 2022 Nov;65(11):1839–1848. https://doi.org/10.1007/s00125-022-05721-6 Merino J . Precision nutrition in diabetes: when population-based dietary advice gets personal . Diabetologia. 2022 Nov ; 65 ( 11 ): 1839 – 1848 . https://doi.org/10.1007/s00125-022-05721-6 Search in Google Scholar

Naseri K, Saadati S, Ashtary-Larky D, Asbaghi O, Ghaemi F, Pashayee-Khamene F, Yari Z, de Courten B. Probiotics and synbiotics supplementation improve glycemic control parameters in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. Pharmacol Res. 2022 Oct;184:106399. https://doi.org/10.1016/j.phrs.2022.106399 Naseri K Saadati S Ashtary-Larky D Asbaghi O Ghaemi F Pashayee-Khamene F Yari Z de Courten B . Probiotics and synbiotics supplementation improve glycemic control parameters in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials . Pharmacol Res. 2022 Oct ; 184 : 106399 . https://doi.org/10.1016/j.phrs.2022.106399 Search in Google Scholar

Nie Q, Hu J, Chen H, Geng F, Nie S. Arabinoxylan ameliorates type 2 diabetes by regulating the gut microbiota and metabolites. Food Chem. 2022 Mar;371:131106. https://doi.org/10.1016/j.foodchem.2021.131106 Nie Q Hu J Chen H Geng F Nie S . Arabinoxylan ameliorates type 2 diabetes by regulating the gut microbiota and metabolites . Food Chem. 2022 Mar ; 371 : 131106 . https://doi.org/10.1016/j.foodchem.2021.131106 Search in Google Scholar

Okesene-Gafa KA, Moore AE, Jordan V, McCowan L, Crowther CA. Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well-being. Cochrane Database Syst Rev. 2020 Jun;6(6):CD012970. https://doi.org//10.1002/14651858.CD012970.pub2 Okesene-Gafa KA Moore AE Jordan V McCowan L Crowther CA . Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well-being . Cochrane Database Syst Rev. 2020 Jun ; 6 ( 6 ): CD012970 . https://doi.org//10.1002/14651858.CD012970.pub2 Search in Google Scholar

Peng M, Tabashsum Z, Anderson M, Truong A, Houser AK, Padilla J, Akmel A, Bhatti J, Rahaman SO, Biswas D. Effectiveness of probiotics, prebiotics, and prebiotic-like components in common functional foods. Compr Rev Food Sci Food Saf. 2020 Jul;19(4): 1908–1933. https://doi.org/10.1111/1541-4337.12565 Peng M Tabashsum Z Anderson M Truong A Houser AK Padilla J Akmel A Bhatti J Rahaman SO Biswas D . Effectiveness of probiotics, prebiotics, and prebiotic-like components in common functional foods . Compr Rev Food Sci Food Saf. 2020 Jul ; 19 ( 4 ): 1908 – 1933 . https://doi.org/10.1111/1541-4337.12565 Search in Google Scholar

Pingitore A, Chambers ES, Hill T, Maldonado IR, Liu B, Bewick G, Morrison DJ, Preston T, Wallis GA, Tedford C, et al. The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro. Diabetes Obes Metab. 2017 Feb;19(2):257–265. https://doi.org/10.1111/dom.12811 Pingitore A Chambers ES Hill T Maldonado IR Liu B Bewick G Morrison DJ Preston T Wallis GA Tedford C The diet-derived short chain fatty acid propionate improves beta-cell function in humans and stimulates insulin secretion from human islets in vitro . Diabetes Obes Metab. 2017 Feb ; 19 ( 2 ): 257 – 265 . https://doi.org/10.1111/dom.12811 Search in Google Scholar

Rittiphairoj T, Pongpirul K, Janchot K, Mueller NT, Li T. Probiotics contribute to glycemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. Adv Nutr. 2021 May;12(3):722–734. https://doi.org/10.1093/advances/nmaa133 Rittiphairoj T Pongpirul K Janchot K Mueller NT Li T . Probiotics contribute to glycemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis . Adv Nutr. 2021 May ; 12 ( 3 ): 722 – 734 . https://doi.org/10.1093/advances/nmaa133 Search in Google Scholar

Robertson MD. Prebiotics and type 2 diabetes: targeting the gut microbiota for improved glycaemic control? Pract Diab. 2020 Jul; 37(4):133–137. https://doi.org/10.1002/pdi.2285 Robertson MD . Prebiotics and type 2 diabetes: targeting the gut microbiota for improved glycaemic control? Pract Diab. 2020 Jul ; 37 ( 4 ): 133 – 137 . https://doi.org/10.1002/pdi.2285 Search in Google Scholar

Rodrigues RR, Gurung M, Li Z, García-Jaramillo M, Greer R, Gaulke C, Bauchinger F, You H, Pederson JW, Vasquez-Perez S, et al. Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes. Nat Commun. 2021 Jan;12(1):101. https://doi.org/10.1038/s41467-020-20313-x Rodrigues RR Gurung M Li Z García-Jaramillo M Greer R Gaulke C Bauchinger F You H Pederson JW Vasquez-Perez S Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes . Nat Commun. 2021 Jan ; 12 ( 1 ): 101 . https://doi.org/10.1038/s41467-020-20313-x Search in Google Scholar

Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EMM, Sanders ME, Shamir R, Swann JR, Szajewska H, et al. The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol. 2021 Sep;18(9):649–667. https://doi.org/10.1038/s41575-021-00440-6 Salminen S Collado MC Endo A Hill C Lebeer S Quigley EMM Sanders ME Shamir R Swann JR Szajewska H The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics . Nat Rev Gastroenterol Hepatol. 2021 Sep ; 18 ( 9 ): 649 – 667 . https://doi.org/10.1038/s41575-021-00440-6 Search in Google Scholar

Schmidt TSB, Raes J, Bork P. The human gut microbiome: from association to modulation. cell. 2018 Mar;172(6):1198–1215. https://doi.org/10.1016/j.cell.2018.02.044 Schmidt TSB Raes J Bork P . The human gut microbiome: from association to modulation . cell. 2018 Mar ; 172 ( 6 ): 1198 – 1215 . https://doi.org/10.1016/j.cell.2018.02.044 Search in Google Scholar

Shaukat A, Levitt MD, Taylor BC, MacDonald R, Shamliyan TA, Kane RL, Wilt TJ. Systematic review: effective management strategies for lactose intolerance. Ann Intern Med. 2010 Jun;152(12):797–803. https://doi.org/10.7326/0003-4819-152-12-201006150-00241 Shaukat A Levitt MD Taylor BC MacDonald R Shamliyan TA Kane RL Wilt TJ . Systematic review: effective management strategies for lactose intolerance . Ann Intern Med. 2010 Jun ; 152 ( 12 ): 797 – 803 . https://doi.org/10.7326/0003-4819-152-12-201006150-00241 Search in Google Scholar

Song X, Dong H, Zang Z, Wu W, Zhu W, Zhang H, Guan Y. Kudzu resistant starch: an effective regulator of type 2 diabetes mellitus. Oxid Med Cell Longev. 2021 Oct;2021:1–15. https://doi.org/10.1155/2021/4448048 Song X Dong H Zang Z Wu W Zhu W Zhang H Guan Y . Kudzu resistant starch: an effective regulator of type 2 diabetes mellitus . Oxid Med Cell Longev. 2021 Oct ; 2021 : 1 – 15 . https://doi.org/10.1155/2021/4448048 Search in Google Scholar

Sonnenburg JL, Bäckhed F. Diet – microbiota interactions as moderators of human metabolism. Nature. 2016 Jul;535(7610):56–64. https://doi.org/10.1038/nature18846 Sonnenburg JL Bäckhed F . Diet – microbiota interactions as moderators of human metabolism . Nature. 2016 Jul ; 535 ( 7610 ): 56 – 64 . https://doi.org/10.1038/nature18846 Search in Google Scholar

Sun L, Xie C, Wang G, Wu Y, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, et al. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nat Med. 2018 Dec;24(12):1919–1929. https://doi.org/10.1038/s41591-018-0222-4 Sun L Xie C Wang G Wu Y Wu Q Wang X Liu J Deng Y Xia J Chen B Gut microbiota and intestinal FXR mediate the clinical benefits of metformin . Nat Med. 2018 Dec ; 24 ( 12 ): 1919 – 1929 . https://doi.org/10.1038/s41591-018-0222-4 Search in Google Scholar

Sun L, Yu Z, Ye X, Zou S, Li H, Yu D, Wu H, Chen Y, Dore J, Clément K, et al. A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese. Diabetes Care. 2010 Sep;33(9):1925–1932. https://doi.org/10.2337/dc10-0340 Sun L Yu Z Ye X Zou S Li H Yu D Wu H Chen Y Dore J Clément K A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese . Diabetes Care. 2010 Sep ; 33 ( 9 ): 1925 – 1932 . https://doi.org/10.2337/dc10-0340 Search in Google Scholar

Swanson KS, Gibson GR, Hutkins R, Reimer RA, Reid G, Verbeke K, Scott KP, Holscher HD, Azad MB, Delzenne NM, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020 Nov;17(11):687–701. https://doi.org/10.1038/s41575-020-0344-2 Swanson KS Gibson GR Hutkins R Reimer RA Reid G Verbeke K Scott KP Holscher HD Azad MB Delzenne NM The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics . Nat Rev Gastroenterol Hepatol. 2020 Nov ; 17 ( 11 ): 687 – 701 . https://doi.org/10.1038/s41575-020-0344-2 Search in Google Scholar

Tao YW, Gu YL, Mao XQ, Zhang L, Pei YF. Effects of probiotics on type II diabetes mellitus: a meta-analysis. J Transl Med. 2020 Dec; 18(1):30. https://doi.org/10.1186/s12967-020-02213-2 Tao YW Gu YL Mao XQ Zhang L Pei YF . Effects of probiotics on type II diabetes mellitus: a meta-analysis . J Transl Med. 2020 Dec ; 18 ( 1 ): 30 . https://doi.org/10.1186/s12967-020-02213-2 Search in Google Scholar

Tonucci LB, Olbrich dos Santos KM, Licursi de Oliveira L, Rocha Ribeiro SM, Duarte Martino HS. Clinical application of probiotics in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Clin Nutr. 2017 Feb;36(1):85–92. https://doi.org/10.1016/j.clnu.2015.11.011 Tonucci LB Olbrich dos Santos KM Licursi de Oliveira L Rocha Ribeiro SM Duarte Martino HS . Clinical application of probiotics in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study . Clin Nutr. 2017 Feb ; 36 ( 1 ): 85 – 92 . https://doi.org/10.1016/j.clnu.2015.11.011 Search in Google Scholar

Waddell IS, Orfila C. Dietary fiber in the prevention of obesity and obesity-related chronic diseases: from epidemiological evidence to potential molecular mechanisms. Crit Rev Food Sci Nutr. 2022 Apr; 1–16. https://doi.org/10.1080/10408398.2022.2061909 Waddell IS Orfila C . Dietary fiber in the prevention of obesity and obesity-related chronic diseases: from epidemiological evidence to potential molecular mechanisms . Crit Rev Food Sci Nutr. 2022 Apr ; 1 – 16 . https://doi.org/10.1080/10408398.2022.2061909 Search in Google Scholar

Wan MLY, Forsythe SJ, El-Nezami H. Probiotics interaction with foodborne pathogens: a potential alternative to antibiotics and future challenges. Crit Rev Food Sci Nutr. 2019 Nov;59(20):3320–3333. https://doi.org/10.1080/10408398.2018.1490885 Wan MLY Forsythe SJ El-Nezami H . Probiotics interaction with foodborne pathogens: a potential alternative to antibiotics and future challenges . Crit Rev Food Sci Nutr. 2019 Nov ; 59 ( 20 ): 3320 – 3333 . https://doi.org/10.1080/10408398.2018.1490885 Search in Google Scholar

Wang C, Wei S, Liu B, Wang F, Lu Z, Jin M, Wang Y. Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota. Gut Microbes. 2022 Dec;14(1):2057779. https://doi.org/10.1080/19490976.2022.2057779 Wang C Wei S Liu B Wang F Lu Z Jin M Wang Y . Maternal consumption of a fermented diet protects offspring against intestinal inflammation by regulating the gut microbiota . Gut Microbes. 2022 Dec ; 14 ( 1 ): 2057779 . https://doi.org/10.1080/19490976.2022.2057779 Search in Google Scholar

Wang Y, Dilidaxi D, Wu Y, Sailike J, Sun X, Nabi XH. Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice. Biomed Pharmacother. 2020 May;125:109914. https://doi.org/10.1016/j.biopha.2020.109914 Wang Y Dilidaxi D Wu Y Sailike J Sun X Nabi XH . Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice . Biomed Pharmacother. 2020 May ; 125 : 109914 . https://doi.org/10.1016/j.biopha.2020.109914 Search in Google Scholar

Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011 Oct;334(6052):105–108. https://doi.org/10.1126/science.1208344 Wu GD Chen J Hoffmann C Bittinger K Chen YY Keilbaugh SA Bewtra M Knights D Walters WA Knight R Linking long-term dietary patterns with gut microbial enterotypes . Science. 2011 Oct ; 334 ( 6052 ): 105 – 108 . https://doi.org/10.1126/science.1208344 Search in Google Scholar

Yan F, Li N, Yue Y, Wang C, Zhao L, Evivie SE, Li B, Huo G. Screening for potential novel probiotics with dipeptidyl peptidase IV-inhibiting activity for type 2 diabetes attenuation in vitro and in vivo. Front Microbiol. 2020 Jan;10:2855. https://doi.org/10.3389/fmicb.2019.02855 Yan F Li N Yue Y Wang C Zhao L Evivie SE Li B Huo G . Screening for potential novel probiotics with dipeptidyl peptidase IV-inhibiting activity for type 2 diabetes attenuation in vitro and in vivo . Front Microbiol. 2020 Jan ; 10 : 2855 . https://doi.org/10.3389/fmicb.2019.02855 Search in Google Scholar

Ye J, Lv L, Wu W, Li Y, Shi D, Fang D, Guo F, Jiang H, Yan R, Ye W, et al. Butyrate protects mice against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis by improving gut barrier function, attenuating inflammation and reducing endotoxin levels. Front Microbiol. 2018 Aug;9:1967. https://doi.org/10.3389/fmicb.2018.01967 Ye J Lv L Wu W Li Y Shi D Fang D Guo F Jiang H Yan R Ye W Butyrate protects mice against methionine-choline-deficient diet-induced non-alcoholic steatohepatitis by improving gut barrier function, attenuating inflammation and reducing endotoxin levels . Front Microbiol. 2018 Aug ; 9 : 1967 . https://doi.org/10.3389/fmicb.2018.01967 Search in Google Scholar

Zhang Y, Gu Y, Ren H, Wang S, Zhong H, Zhao X, Ma J, Gu X, Xue Y, Huang S, et al. Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study). Nat Commun. 2020 Oct;11(1):5015. https://doi.org/10.1038/s41467-020-18414-8 Zhang Y Gu Y Ren H Wang S Zhong H Zhao X Ma J Gu X Xue Y Huang S Gut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study) . Nat Commun. 2020 Oct ; 11 ( 1 ): 5015 . https://doi.org/10.1038/s41467-020-18414-8 Search in Google Scholar

Zhao L, Zhang F, Ding X, Wu G, Lam YY, Wang X, Fu H, Xue X, Lu C, Ma J, et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes. Science. 2018 Mar;359(6380):1151–1156. https://doi.org/10.1126/science.aao5774 Zhao L Zhang F Ding X Wu G Lam YY Wang X Fu H Xue X Lu C Ma J Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes . Science. 2018 Mar ; 359 ( 6380 ): 1151 – 1156 . https://doi.org/10.1126/science.aao5774 Search in Google Scholar

Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018 Feb;14(2):88–98. https://doi.org/10.1038/nrendo.2017.151 Zheng Y Ley SH Hu FB . Global aetiology and epidemiology of type 2 diabetes mellitus and its complications . Nat Rev Endocrinol. 2018 Feb ; 14 ( 2 ): 88 – 98 . https://doi.org/10.1038/nrendo.2017.151 Search in Google Scholar

Zhong H, Abdullah, Zhao M, Tang J, Deng L, Feng F. Probiotics-fermented blueberry juices as potential antidiabetic product: anti-oxidant, antimicrobial and antidiabetic potentials. J Sci Food Agric. 2021 Aug;101(10):4420–4427. https://doi.org/10.1002/jsfa.11083 Zhong H Abdullah Zhao M Tang J Deng L Feng F . Probiotics-fermented blueberry juices as potential antidiabetic product: anti-oxidant, antimicrobial and antidiabetic potentials . J Sci Food Agric. 2021 Aug ; 101 ( 10 ): 4420 – 4427 . https://doi.org/10.1002/jsfa.11083 Search in Google Scholar