Acceso abierto

Recent Transmission and Prevalent Characterization of the Beijing Family Mycobacterium tuberculosis in Jiangxi, China

Dong Luo
Dong Luo
, 
Shengming Yu
Shengming Yu
, 
Yuyang Huang
Yuyang Huang
, 
Jiahuan Zhan
Jiahuan Zhan
, 
Qiang Chen
Qiang Chen
, 
Liang Yan
Liang Yan
 y 
Kaisen Chen
Kaisen Chen
   | 24 sept 2022
Polish Journal of Microbiology's Cover Image
Acerca de este artículo
Artículo anterior
Artículo siguiente
Cite
Article Category: Original Paper
Publicado en línea: 24 sept 2022
Páginas: 371 - 380
Recibido: 15 abr 2022
Aceptado: 09 jul 2022
DOI: https://doi.org/10.33073/pjm-2022-033
Palabras clave
© 2022 Dong Luo et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Fig. 1

The MIRU-VNTR genotypes in Jiangxi province, China – the study design. NTM – nontuberculous mycobacteria.
The MIRU-VNTR genotypes in Jiangxi province, China – the study design. NTM – nontuberculous mycobacteria.

Fig. 2

Map of Jiangxi showing the distribution of 1,433 isolates included in this study (the numbers indicate the absolute number of isolates in every region).
Map of Jiangxi showing the distribution of 1,433 isolates included in this study (the numbers indicate the absolute number of isolates in every region).

Prevalent characterization of Beijing and non-Beijing family strains.

Characteristics Beijing family Non-Beijing family
Clustered n = 612 Non-clustered n = 508 OR (95% CI) p-value Clustered n = 46 Non-clustered n = 267 OR (95% CI) p-value
Sex
Men 384 267 –   – 32 177 – –
Women 228 241 1.210.–512. 93 0 .001 14 90 0.519.–126. 29 0.74
Age
≤ 30 187 176 – – 13 78 – –
30–50 232 149 0.501.–608. 91 0 .01 19 67 0.207.5–818.2 8 0.24
≥ 50 193 183 0.716.–011. 34 1 .00 14 122 0.615.–435. 25 0.41
Treatment history
New 530 461 – – 32 203 – –
Recurrent 67 38 0.403.–605. 99 0 .05 11 52 0.305.–714. 58 0.42
Treatment failure 15 9 0.300.–619. 59 0 .42 3 14 0.200.–724. 70 0.71
HIV status
Positive 28 23 – – 2 14 – –
Negative 584 485 0.518.–011. 78 1 .00 44 253 0.108.–832. 74 1.00
Sputum
Negative 121 104 – – 12 83 – –
Positive 391 404 0.819.–210. 62 0 .23 34 184 0.309.–718. 59 0.60
Cavity
No 494 432 – – 39 225 – –
Yes 118 76 0.919.–316. 86 0 .07 7 42 0.400.–926. 30 1.00

Demographic and drug-resistant characteristics of this study’s isolates (n = 1,433).

Characteristics Number Beijing family Non-Beijing family OR (95% CI) p-value
All 1,433 1,120 313 –   –
Sex
Men 860 651 209 –   –
Women 57 3 41 9 154 0.910.–114. 46 0.29
Age
≥ 50 512 376 136 –   –
30–50 46 7 38 1 86 1.114.–414. 83 0.003
≤ 30 45 4 36 3 91 1.015.–313. 67 0.02
Treatment history
New 1,174 900 274 –   –
Recurrent 16 8 14 5 23 0.303.–502. 83 0.004
Treatment failure 91   7 5 16 0.400.–710. 22 0.24
Region
Southern regions 249 181 68 –   –
Central regions 72 2 56 7 155 0.502.–713. 01 0.07
Northern regions 46 2 37 2 90 0.405.–604. 92 0.02
DST profile
DST profile 1,433 1,120 313 –   –
Pansusceptible 99 2 79 4 198 0.703.–819. 09 0.27
RIF   2 7   1 8 9 0.810.–749. 02 0.16
INH   3 3   2 5 8 0.511.–124. 56 0.68
SM   5 2   4 4 8 0.300.–615. 40 0.31
EMB    6    5 1 0.008.–762. 15 1.00
AK   1 9   1 5 4 0.301.–925. 90 1.00
CM   1 8   1 3 5 0.419.–338. 89 0.57
LEV   3 8   3 0 8 0.403.–925. 10 1.00
RIF + INH   5 6   4 7 9 0.303.–618. 41 0.41
RIF + SM   2 0   1 5 5 0.413.–139. 31 0.78
INH + SM   4 1   3 4 7 0.302.–714. 68 0.57
RIF + EMB    5    3 2 0.402–.3194 .34 0.30
INH + EMB    1    1 0 –   –
RIF + INH + EMB   7 1   6 0 11 0.304.–616. 26 0.24
RIF + INH + SM   2 9   2 5 4 0.200.–517. 66 0.37
INH + SM + EMB    5    4 1 0.100.–980. 03 1.00
RIF + INH + SM + EMB    2    1 1 0.223–.5587 .37 0.39
MDR 158 133 25 0.410.64 –1.01 0.05

Prevalent characterization of clustered and non-clustered strains.

Characteristics Clustered Non-clustered
Beijing family n = 612 Non-Beijing family n = 46 OR (95%CI) p-value Beijing family n = 508 Non-Beijing family n = 267 OR (95%CI) p-value
Sex
Men 384 32 –   – 267 177 – –
Women 228 14 0.308.–714. 41 0.43 241 90 0.401.–506. 77 < 0.001
Age
≤ 30 187 13 – – 176 78 – –
30–50 232 19 0.517.–128. 45 0.72 149 67 0.618.–012. 50 1.00
≥ 50 193 14 0.418.–024. 28 1.00 183 122 1.016.5–024.1 4 0.03
Treatment history
New 507 28 – – 443 246 – –
Recurrent 84 14 1.533.–052. 97 0.003 61 9 0.103.2–606.5 4 0.00
Treatment failure 21 4 1.131.–41409. 73 0.05 4 12 1.752.–41062. 93 0.002
HIV status
Negative 584 37 –   – 485 260 – –
Positive 28 9 0.009.–200. 45 0.001 23 7 0.715.–746. 16 0.24
Sputum
Negative 121 12 –   – 104 83 – –
Positive 391 34 0.440.88 –1.75 0.72 404 184 0.410.57 –0.80 0.001
Cavity
Yes 108 7 –   – 86 42 – –
No 504 39 0.512.–129. 74 0.84 422 225 0.713.–019. 63 0.76
eISSN:
2544-4646
Idioma:
Inglés
Calendario de la edición:
4 veces al año
Temas de la revista:
Life Sciences, Microbiology and Virology
RSS Feed de revista