<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Colistin is a member of cationic polypeptide antibiotics known as polymyxins. It is widely used in animal husbandry, plant cultivation, animal and human medicine and is increasingly used as one of the last available treatment options for patients with severe infections with carbapenem-resistant Gram-negative bacilli. Due to the increased use of colistin in treating infections caused by multidrug-resistant (MDR) bacteria, the resistance to this antibiotic ought to be monitored. Bacterial resistance to colistin may be encoded on transposable genetic elements (e.g. plasmids with the <italic>mcr</italic> genes). Thus far, nine variants of the <italic>mcr</italic> gene, <italic>mcr-1 – mcr-9</italic>, have been identified. Chromosomal resistance to colistin is associated with the modification of lipopolysaccharide (LPS). Various methods, from classical microbiology to molecular biology methods, are used to detect the colistin-resistant bacterial strains and to identify resistance mechanisms. The broth dilution method is recommended for susceptibility testing of bacteria to colistin.</p></abstract>

Colistin is a member of cationic polypeptide antibiotics known as polymyxins. It is widely used in animal husbandry, plant cultivation, animal and human medicine and is increasingly used as one of the last available treatment options for patients with severe infections with carbapenem-resistant Gram-negative bacilli. Due to the increased use of colistin in treating infections caused by multidrug-resistant (MDR) bacteria, the resistance to this antibiotic ought to be monitored. Bacterial resistance to colistin may be encoded on transposable genetic elements (e.g. plasmids with the mcr genes). Thus far, nine variants of the mcr gene, mcr-1 – mcr-9, have been identified. Chromosomal resistance to colistin is associated with the modification of lipopolysaccharide (LPS). Various methods, from classical microbiology to molecular biology methods, are used to detect the colistin-resistant bacterial strains and to identify resistance mechanisms. The broth dilution method is recommended for susceptibility testing of bacteria to colistin.

Colistin Resistance in Enterobacterales Strains – A Current View

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Colistin Resistance in Enterobacterales Strains \u2013 A Current View"}

Colistin is a member of cationic polypeptide antibiotics known as polymyxins. It is widely used in animal husbandry, plant cultivation, animal and human...

Colistin Resistance in Enterobacterales Strains – A Current View

Article Category: mini-review

Publicado en línea: 05 dic 2019

Páginas: 417 - 427

Recibido: 18 jun 2019

Aceptado: 05 nov 2019

DOI: https://doi.org/10.33073/pjm-2019-055

Palabras clave
Enterobacterales, polymyxins and their use, colistin-resistance and detection methods, treatment options

© 2019 MATEJ REMENÁR et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Colistin Resistance in Enterobacterales Strains – A Current View

Article Category: mini-review

Publicado en línea: 05 dic 2019

Páginas: 417 - 427

Recibido: 18 jun 2019

Aceptado: 05 nov 2019

DOI: https://doi.org/10.33073/pjm-2019-055

Palabras claveEnterobacterales, polymyxins and their use, colistin-resistance and detection methods, treatment options

© 2019 MATEJ REMENÁR et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Palabras clave
Enterobacterales, polymyxins and their use, colistin-resistance and detection methods, treatment options