<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Colistin is a member of cationic polypeptide antibiotics known as polymyxins. It is widely used in animal husbandry, plant cultivation, animal and human medicine and is increasingly used as one of the last available treatment options for patients with severe infections with carbapenem-resistant Gram-negative bacilli. Due to the increased use of colistin in treating infections caused by multidrug-resistant (MDR) bacteria, the resistance to this antibiotic ought to be monitored. Bacterial resistance to colistin may be encoded on transposable genetic elements (e.g. plasmids with the <italic>mcr</italic> genes). Thus far, nine variants of the <italic>mcr</italic> gene, <italic>mcr-1 – mcr-9</italic>, have been identified. Chromosomal resistance to colistin is associated with the modification of lipopolysaccharide (LPS). Various methods, from classical microbiology to molecular biology methods, are used to detect the colistin-resistant bacterial strains and to identify resistance mechanisms. The broth dilution method is recommended for susceptibility testing of bacteria to colistin.</p></abstract>

Colistin is a member of cationic polypeptide antibiotics known as polymyxins. It is widely used in animal husbandry, plant cultivation, animal and human medicine and is increasingly used as one of the last available treatment options for patients with severe infections with carbapenem-resistant Gram-negative bacilli. Due to the increased use of colistin in treating infections caused by multidrug-resistant (MDR) bacteria, the resistance to this antibiotic ought to be monitored. Bacterial resistance to colistin may be encoded on transposable genetic elements (e.g. plasmids with the mcr genes). Thus far, nine variants of the mcr gene, mcr-1 – mcr-9, have been identified. Chromosomal resistance to colistin is associated with the modification of lipopolysaccharide (LPS). Various methods, from classical microbiology to molecular biology methods, are used to detect the colistin-resistant bacterial strains and to identify resistance mechanisms. The broth dilution method is recommended for susceptibility testing of bacteria to colistin.

Colistin Resistance in Enterobacterales Strains – A Current View

Polish Journal of Microbiology

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

{"article-title":"Colistin Resistance in Enterobacterales Strains \u2013 A Current View"}

Colistin is a member of cationic polypeptide antibiotics known as polymyxins. It is widely used in animal husbandry, plant cultivation, animal and human...

Colistin Resistance in Enterobacterales Strains – A Current View

Article Category: mini-review

Published Online: Dec 05, 2019

Page range: 417 - 427

Received: Jun 18, 2019

Accepted: Nov 05, 2019

DOI: https://doi.org/10.33073/pjm-2019-055

Keywords
Enterobacterales, polymyxins and their use, colistin-resistance and detection methods, treatment options

© 2019 MATEJ REMENÁR et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Colistin Resistance in Enterobacterales Strains – A Current View

Article Category: mini-review

Published Online: Dec 05, 2019

Page range: 417 - 427

Received: Jun 18, 2019

Accepted: Nov 05, 2019

DOI: https://doi.org/10.33073/pjm-2019-055

KeywordsEnterobacterales, polymyxins and their use, colistin-resistance and detection methods, treatment options

© 2019 MATEJ REMENÁR et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Keywords
Enterobacterales, polymyxins and their use, colistin-resistance and detection methods, treatment options